{
    "title": "The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B.",
    "journal": "The Journal of biological chemistry",
    "date": "1999",
    "authors": "Moeslein FM, Myers MP, Landreth GE",
    "reference": {
        "type": "PubMed",
        "id": "10480872",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10480872"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P49760-1",
            "protein_name": "Dual specificity protein kinase CLK2",
            "gene_name": "CLK2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P25044-1",
            "protein_name": "Tyrosine-protein phosphatase 1",
            "gene_name": "PTP1",
            "tax_name": "Baker's yeast"
        },
        {
            "uniprot_canonical_ac": "P49759-1",
            "protein_name": "Dual specificity protein kinase CLK1",
            "gene_name": "CLK1",
            "tax_name": "Human"
        },
        {
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            "protein_name": "Tyrosine-protein phosphatase non-receptor type 1",
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    ],
    "species": [
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            "name": "Homo sapiens",
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                    "url": "https://www.uniprot.org/uniprot/P49760"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "phosphorylation": [
        {
            "start_pos": 83,
            "end_pos": 83,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine; by CLK1",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P25044",
                    "url": "https://www.uniprot.org/uniprot/P25044"
                },
                {
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                    "id": "P25044",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P25044"
                },
                {
                    "database": "PubMed",
                    "id": "10480872",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10480872"
                }
            ],
            "site_lbl": "Ser83",
            "uniprot_canonical_ac": "P25044-1"
        },
        {
            "start_pos": 242,
            "end_pos": 242,
            "kinase_uniprot_canonical_ac": "P49759-1",
            "kinase_gene_name": "CLK1",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
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                    "id": "P18031",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P18031"
                },
                {
                    "database": "PubMed",
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            ],
            "site_lbl": "Ser242",
            "uniprot_canonical_ac": "P18031-1"
        },
        {
            "start_pos": 242,
            "end_pos": 242,
            "kinase_uniprot_canonical_ac": "P49760-1",
            "kinase_gene_name": "CLK2",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
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                    "id": "P18031",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P18031"
                },
                {
                    "database": "PubMed",
                    "id": "10480872",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10480872"
                }
            ],
            "site_lbl": "Ser242",
            "uniprot_canonical_ac": "P18031-1"
        },
        {
            "start_pos": 242,
            "end_pos": 242,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine; by CLK1 and CLK2",
            "evidence": [
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                    "id": "P18031",
                    "url": "https://www.uniprot.org/uniprot/P18031"
                },
                {
                    "database": "IntAct",
                    "id": "P18031",
                    "url": "https://www.ebi.ac.uk/intact/interactors/id:P18031*"
                },
                {
                    "database": "iPTMnet",
                    "id": "P18031",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P18031"
                },
                {
                    "database": "PubMed",
                    "id": "10480872",
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                }
            ],
            "site_lbl": "Ser242",
            "uniprot_canonical_ac": "P18031-1"
        },
        {
            "start_pos": 243,
            "end_pos": 243,
            "kinase_uniprot_canonical_ac": "P49759-1",
            "kinase_gene_name": "CLK1",
            "residue": "Ser",
            "comment": "",
            "evidence": [
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                    "id": "P18031",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P18031"
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                {
                    "database": "PubMed",
                    "id": "10480872",
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                }
            ],
            "site_lbl": "Ser243",
            "uniprot_canonical_ac": "P18031-1"
        },
        {
            "start_pos": 243,
            "end_pos": 243,
            "kinase_uniprot_canonical_ac": "P49760-1",
            "kinase_gene_name": "CLK2",
            "residue": "Ser",
            "comment": "",
            "evidence": [
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                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P18031"
                },
                {
                    "database": "PubMed",
                    "id": "10480872",
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                }
            ],
            "site_lbl": "Ser243",
            "uniprot_canonical_ac": "P18031-1"
        },
        {
            "start_pos": 243,
            "end_pos": 243,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine; by CLK1 and CLK2",
            "evidence": [
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                    "id": "P18031",
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                {
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                    "id": "P18031",
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                {
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                    "id": "P18031",
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                {
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            ],
            "site_lbl": "Ser243",
            "uniprot_canonical_ac": "P18031-1"
        },
        {
            "start_pos": 50,
            "end_pos": 50,
            "kinase_uniprot_canonical_ac": "P49759-1",
            "kinase_gene_name": "CLK1",
            "residue": "Ser",
            "comment": "",
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                },
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                },
                {
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                },
                {
                    "database": "PubMed",
                    "id": "10480872",
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                },
                {
                    "database": "phospho.ELM",
                    "id": "P18031",
                    "url": "http://phospho.elm.eu.org/byAccession/P18031.html"
                }
            ],
            "site_lbl": "Ser50",
            "uniprot_canonical_ac": "P18031-1"
        },
        {
            "start_pos": 50,
            "end_pos": 50,
            "kinase_uniprot_canonical_ac": "P49760-1",
            "kinase_gene_name": "CLK2",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P18031",
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                },
                {
                    "database": "PubMed",
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                },
                {
                    "database": "PubMed",
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                },
                {
                    "database": "PubMed",
                    "id": "10480872",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10480872"
                }
            ],
            "site_lbl": "Ser50",
            "uniprot_canonical_ac": "P18031-1"
        },
        {
            "start_pos": 50,
            "end_pos": 50,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine; by PKB/AKT1, CLK1 and CLK2",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P18031",
                    "url": "https://www.uniprot.org/uniprot/P18031"
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                {
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                {
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                {
                    "database": "phospho.ELM",
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                {
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                {
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                {
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            "start_pos": 50,
            "end_pos": 50,
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    "abstract": "",
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