{
    "title": "SH2-B, a membrane-associated adapter, is phosphorylated on multiple serines/threonines in response to nerve growth factor by kinases within the MEK/ERK cascade.",
    "journal": "The Journal of biological chemistry",
    "date": "1999",
    "authors": "Rui L, Herrington J, Carter-Su C",
    "reference": {
        "type": "PubMed",
        "id": "10473609",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10473609"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "Q9NRF2-1",
            "protein_name": "SH2B adapter protein 1",
            "gene_name": "SH2B1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q62985-1",
            "protein_name": "SH2B adapter protein 1",
            "gene_name": "Sh2b1",
            "tax_name": "Rat"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9NRF2",
                    "url": "https://www.uniprot.org/uniprot/Q9NRF2"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "phosphorylation": [
        {
            "start_pos": 96,
            "end_pos": 96,
            "kinase_uniprot_canonical_ac": "P27361-1",
            "kinase_gene_name": "MAPK3",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "Q9NRF2",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NRF2"
                },
                {
                    "database": "PubMed",
                    "id": "10473609",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10473609"
                }
            ],
            "site_lbl": "Ser96",
            "uniprot_canonical_ac": "Q9NRF2-1"
        },
        {
            "start_pos": 96,
            "end_pos": 96,
            "kinase_uniprot_canonical_ac": "P28482-1",
            "kinase_gene_name": "MAPK1",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "Q9NRF2",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NRF2"
                },
                {
                    "database": "PubMed",
                    "id": "10473609",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10473609"
                }
            ],
            "site_lbl": "Ser96",
            "uniprot_canonical_ac": "Q9NRF2-1"
        },
        {
            "start_pos": 96,
            "end_pos": 96,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9NRF2",
                    "url": "https://www.uniprot.org/uniprot/Q9NRF2"
                },
                {
                    "database": "PubMed",
                    "id": "18669648",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/18669648"
                },
                {
                    "database": "PubMed",
                    "id": "18220336",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/18220336"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q9NRF2",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9NRF2"
                },
                {
                    "database": "PubMed",
                    "id": "10473609",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10473609"
                }
            ],
            "site_lbl": "Ser96",
            "uniprot_canonical_ac": "Q9NRF2-1"
        },
        {
            "start_pos": 96,
            "end_pos": 96,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine; by MAPK1 or MAPK3; in vitro",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q62985",
                    "url": "https://www.uniprot.org/uniprot/Q62985"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q62985",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q62985"
                },
                {
                    "database": "PubMed",
                    "id": "10473609",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10473609"
                }
            ],
            "site_lbl": "Ser96",
            "uniprot_canonical_ac": "Q62985-1"
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    ],
    "mutagenesis": [
        {
            "start_pos": 96,
            "end_pos": 96,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "Reduces in vitro phosphorylation by MAPK1 and/or MAPK3.",
            "evidence": [
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                    "id": "Q62985",
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    "record_id": "pubmed.10473609",
    "abstract": "",
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    "snv": [],
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