{
    "title": "Molecular identification of the ryanodine receptor pore-forming segment.",
    "journal": "The Journal of biological chemistry",
    "date": "1999",
    "authors": "Zhao M, Li P, Li X, Zhang L, Winkfein RJ, Chen SR",
    "reference": {
        "type": "PubMed",
        "id": "10473538",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10473538"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "E9Q401-1",
            "protein_name": "Ryanodine receptor 2",
            "gene_name": "Ryr2",
            "tax_name": "Mouse"
        }
    ],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
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                    "id": "E9Q401",
                    "url": "https://www.uniprot.org/uniprot/E9Q401"
                }
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            "common_name": "Mouse",
            "glygen_name": "Mouse",
            "reference_species": "Mus musculus [10090]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 4819,
            "end_pos": 4819,
            "sequence_org": "G",
            "sequence_mut": "A",
            "comment": "Strongly reduced calcium channel activity. Abolishes ryanodine binding.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "E9Q401",
                    "url": "https://www.uniprot.org/uniprot/E9Q401"
                },
                {
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                    "id": "10473538",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10473538"
                }
            ],
            "uniprot_canonical_ac": "E9Q401-1"
        },
        {
            "start_pos": 4821,
            "end_pos": 4821,
            "sequence_org": "R",
            "sequence_mut": "A",
            "comment": "No effect on calcium channel activity. Abolishes ryanodine binding.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "E9Q401",
                    "url": "https://www.uniprot.org/uniprot/E9Q401"
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                {
                    "database": "PubMed",
                    "id": "10473538",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10473538"
                }
            ],
            "uniprot_canonical_ac": "E9Q401-1"
        },
        {
            "start_pos": 4823,
            "end_pos": 4823,
            "sequence_org": "G",
            "sequence_mut": "A",
            "comment": "Reduced calcium channel activity. Reduces single channel conductance by 97%. No effect on ryaodine binding.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "E9Q401",
                    "url": "https://www.uniprot.org/uniprot/E9Q401"
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                    "id": "10473538",
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            ],
            "uniprot_canonical_ac": "E9Q401-1"
        },
        {
            "start_pos": 4824,
            "end_pos": 4824,
            "sequence_org": "G",
            "sequence_mut": "A",
            "comment": "No effect on calcium channel activity. Abolishes ryanodine binding.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "E9Q401",
                    "url": "https://www.uniprot.org/uniprot/E9Q401"
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                    "id": "10473538",
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            ],
            "uniprot_canonical_ac": "E9Q401-1"
        },
        {
            "start_pos": 4825,
            "end_pos": 4825,
            "sequence_org": "G",
            "sequence_mut": "A",
            "comment": "Strongly reduced calcium channel activity. Abolishes ryanodine binding.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "E9Q401",
                    "url": "https://www.uniprot.org/uniprot/E9Q401"
                },
                {
                    "database": "PubMed",
                    "id": "10473538",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10473538"
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            ],
            "uniprot_canonical_ac": "E9Q401-1"
        },
        {
            "start_pos": 4827,
            "end_pos": 4827,
            "sequence_org": "G",
            "sequence_mut": "A",
            "comment": "No effect on calcium channel activity. Abolishes ryanodine binding.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "E9Q401",
                    "url": "https://www.uniprot.org/uniprot/E9Q401"
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                    "id": "10473538",
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            "uniprot_canonical_ac": "E9Q401-1"
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            "start_pos": 4828,
            "end_pos": 4828,
            "sequence_org": "D",
            "sequence_mut": "A",
            "comment": "No effect on calcium channel activity. Abolishes ryanodine binding.",
            "evidence": [
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    "abstract": "",
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