{
    "title": "Cysteine 144 is a key residue in the copper reduction by the beta-amyloid precursor protein.",
    "journal": "Journal of neurochemistry",
    "date": "1999",
    "authors": "Ruiz FH, Gonzalez M, Bodini M, Opazo C, Inestrosa NC",
    "reference": {
        "type": "PubMed",
        "id": "10461923",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10461923"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P05067-1",
            "protein_name": "Amyloid-beta precursor protein",
            "gene_name": "APP",
            "tax_name": "Human"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05067",
                    "url": "https://www.uniprot.org/uniprot/P05067"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 144,
            "end_pos": 144,
            "sequence_org": "C",
            "sequence_mut": "S",
            "comment": "Binds copper. No dimer formation. No copper reducing activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05067",
                    "url": "https://www.uniprot.org/uniprot/P05067"
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                {
                    "database": "PubMed",
                    "id": "10461923",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10461923"
                },
                {
                    "database": "PubMed",
                    "id": "7913895",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/7913895"
                }
            ],
            "uniprot_canonical_ac": "P05067-1"
        },
        {
            "start_pos": 147,
            "end_pos": 149,
            "sequence_org": "HLH",
            "sequence_mut": "ALA",
            "comment": "50% decrease in copper reducing activity.",
            "evidence": [
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                    "database": "UniProtKB",
                    "id": "P05067",
                    "url": "https://www.uniprot.org/uniprot/P05067"
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            ],
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    "record_id": "pubmed.10461923",
    "abstract": "",
    "glycosylation": [],
    "snv": [],
    "phosphorylation": [],
    "glycation": [],
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