{
    "title": "The developmental role of warthog, the notch modifier encoding Drab6.",
    "journal": "The Journal of cell biology",
    "date": "1999",
    "authors": "Purcell K, Artavanis-Tsakonas S",
    "reference": {
        "type": "PubMed",
        "id": "10459009",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10459009"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "Q8NES3-1",
            "protein_name": "Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe",
            "gene_name": "LFNG",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q93084-2",
            "protein_name": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 3",
            "gene_name": "ATP2A3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O18334-1",
            "protein_name": "Ras-related protein Rab6",
            "gene_name": "Rab6",
            "tax_name": "Fruit fly"
        },
        {
            "uniprot_canonical_ac": "Q11203-1",
            "protein_name": "CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase",
            "gene_name": "ST3GAL3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P46531-1",
            "protein_name": "Neurogenic locus notch homolog protein 1",
            "gene_name": "NOTCH1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P16615-1",
            "protein_name": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2",
            "gene_name": "ATP2A2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P20340-1",
            "protein_name": "Ras-related protein Rab-6A",
            "gene_name": "RAB6A",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q99466-1",
            "protein_name": "Neurogenic locus notch homolog protein 4",
            "gene_name": "NOTCH4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9UBV2-1",
            "protein_name": "Protein sel-1 homolog 1",
            "gene_name": "SEL1L",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O14983-1",
            "protein_name": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 1",
            "gene_name": "ATP2A1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9Y644-1",
            "protein_name": "Beta-1,3-N-acetylglucosaminyltransferase radical fringe",
            "gene_name": "RFNG",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q11206-1",
            "protein_name": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4",
            "gene_name": "ST3GAL4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9Y274-1",
            "protein_name": "Type 2 lactosamine alpha-2,3-sialyltransferase",
            "gene_name": "ST3GAL6",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9UM47-1",
            "protein_name": "Neurogenic locus notch homolog protein 3",
            "gene_name": "NOTCH3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O00587-1",
            "protein_name": "Beta-1,3-N-acetylglucosaminyltransferase manic fringe",
            "gene_name": "MFNG",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q15363-1",
            "protein_name": "Transmembrane emp24 domain-containing protein 2",
            "gene_name": "TMED2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P15291-1",
            "protein_name": "Beta-1,4-galactosyltransferase 1",
            "gene_name": "B4GALT1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P09958-1",
            "protein_name": "Furin",
            "gene_name": "FURIN",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q04721-1",
            "protein_name": "Neurogenic locus notch homolog protein 2",
            "gene_name": "NOTCH2",
            "tax_name": "Human"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8NES3",
                    "url": "https://www.uniprot.org/uniprot/Q8NES3"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 62,
            "end_pos": 62,
            "sequence_org": "R",
            "sequence_mut": "C",
            "comment": "Produces short bristles but does not alter the direction of their growth.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O18334",
                    "url": "https://www.uniprot.org/uniprot/O18334"
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                    "id": "10459009",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10459009"
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            "uniprot_canonical_ac": "O18334-1"
        },
        {
            "start_pos": 71,
            "end_pos": 71,
            "sequence_org": "Q",
            "sequence_mut": "L",
            "comment": "Impairs maturation of ninaE and Rh3. Causes accumulation of membranes at the base of the rhabdomeres and retinal degeneration. Abolishes interaction with Rich. Alters direction of bristle growth and produces aberrations in the circumferential ridges.",
            "evidence": [
                {
                    "database": "UniProtKB",
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                    "url": "https://www.uniprot.org/uniprot/O18334"
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                {
                    "database": "PubMed",
                    "id": "21835342",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/21835342"
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                {
                    "database": "PubMed",
                    "id": "9685396",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/9685396"
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            ],
            "uniprot_canonical_ac": "O18334-1"
        }
    ],
    "record_id": "pubmed.10459009",
    "abstract": "",
    "glycosylation": [],
    "snv": [],
    "phosphorylation": [],
    "glycation": [],
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