{
    "title": "Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis.",
    "journal": "Mol. Cell. Biol.",
    "date": "1999",
    "authors": "Wang J, Dai H, Yousaf N, Moussaif M, Deng Y, Boufelliga A, Swamy OR, Leone ME, Riedel H",
    "reference": {
        "type": "PubMed",
        "id": "10454568",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10454568"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P08581-1",
            "protein_name": "Hepatocyte growth factor receptor",
            "gene_name": "MET",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P09619-1",
            "protein_name": "Platelet-derived growth factor receptor beta",
            "gene_name": "PDGFRB",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P05622-1",
            "protein_name": "Platelet-derived growth factor receptor beta",
            "gene_name": "Pdgfrb",
            "tax_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "P11362-1",
            "protein_name": "Fibroblast growth factor receptor 1",
            "gene_name": "FGFR1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q60760-1",
            "protein_name": "Growth factor receptor-bound protein 10",
            "gene_name": "Grb10",
            "tax_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "P08069-1",
            "protein_name": "Insulin-like growth factor 1 receptor",
            "gene_name": "IGF1R",
            "tax_name": "Human"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P08581",
                    "url": "https://www.uniprot.org/uniprot/P08581"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 1009,
            "end_pos": 1009,
            "sequence_org": "Y",
            "sequence_mut": "F",
            "comment": "No effect on interaction with GRB10. Abolishes interaction with PLCG1; when associated with F-1021.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P09619",
                    "url": "https://www.uniprot.org/uniprot/P09619"
                },
                {
                    "database": "PubMed",
                    "id": "1396585",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/1396585"
                },
                {
                    "database": "PubMed",
                    "id": "7691811",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/7691811"
                },
                {
                    "database": "PubMed",
                    "id": "10454568",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10454568"
                }
            ],
            "uniprot_canonical_ac": "P09619-1"
        },
        {
            "start_pos": 1021,
            "end_pos": 1021,
            "sequence_org": "Y",
            "sequence_mut": "F",
            "comment": "Strongly reduces up-regulation of cell proliferation. Abolishes interaction with PLCG1; when associated with F-1009. No effect on interaction with GRB10.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P09619",
                    "url": "https://www.uniprot.org/uniprot/P09619"
                },
                {
                    "database": "PubMed",
                    "id": "21679854",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/21679854"
                },
                {
                    "database": "PubMed",
                    "id": "1396585",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/1396585"
                },
                {
                    "database": "PubMed",
                    "id": "17620338",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/17620338"
                },
                {
                    "database": "PubMed",
                    "id": "10454568",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10454568"
                }
            ],
            "uniprot_canonical_ac": "P09619-1"
        },
        {
            "start_pos": 579,
            "end_pos": 579,
            "sequence_org": "Y",
            "sequence_mut": "F",
            "comment": "Loss of kinase activity; when associated with F-581. Strongly reduces interaction with SRC family kinases. No effect on interaction with GRB10.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P09619",
                    "url": "https://www.uniprot.org/uniprot/P09619"
                },
                {
                    "database": "PubMed",
                    "id": "7685273",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/7685273"
                },
                {
                    "database": "PubMed",
                    "id": "10454568",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10454568"
                }
            ],
            "uniprot_canonical_ac": "P09619-1"
        },
        {
            "start_pos": 581,
            "end_pos": 581,
            "sequence_org": "Y",
            "sequence_mut": "F",
            "comment": "Loss of kinase activity; when associated with F-579. No effect on interaction with GRB10.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P09619",
                    "url": "https://www.uniprot.org/uniprot/P09619"
                },
                {
                    "database": "PubMed",
                    "id": "7685273",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/7685273"
                },
                {
                    "database": "PubMed",
                    "id": "10454568",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10454568"
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            ],
            "uniprot_canonical_ac": "P09619-1"
        },
        {
            "start_pos": 716,
            "end_pos": 716,
            "sequence_org": "Y",
            "sequence_mut": "F",
            "comment": "No effect neither on interaction with GRB10 and RASA1 nor on phosphatidylinositol 3-kinase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P09619",
                    "url": "https://www.uniprot.org/uniprot/P09619"
                },
                {
                    "database": "PubMed",
                    "id": "1314164",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/1314164"
                },
                {
                    "database": "PubMed",
                    "id": "10454568",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10454568"
                }
            ],
            "uniprot_canonical_ac": "P09619-1"
        },
        {
            "start_pos": 740,
            "end_pos": 740,
            "sequence_org": "Y",
            "sequence_mut": "F",
            "comment": "Strongly reduces up-regulation of cell proliferation; when associated with F-751. Strongly decreases phosphatidylinositol 3-kinase activity. No effect on interaction with GRB10 and RASA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P09619",
                    "url": "https://www.uniprot.org/uniprot/P09619"
                },
                {
                    "database": "PubMed",
                    "id": "21679854",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/21679854"
                },
                {
                    "database": "PubMed",
                    "id": "1314164",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/1314164"
                },
                {
                    "database": "PubMed",
                    "id": "10454568",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10454568"
                },
                {
                    "database": "PubMed",
                    "id": "1375321",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/1375321"
                }
            ],
            "uniprot_canonical_ac": "P09619-1"
        },
        {
            "start_pos": 751,
            "end_pos": 751,
            "sequence_org": "Y",
            "sequence_mut": "F",
            "comment": "Strongly reduces up-regulation of cell proliferation; when associated with F-740. Abolishes phosphatidylinositol 3-kinase activity and interaction with NCK1, and slightly reduces interaction with RASA1. No effect on interaction with GRB10.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P09619",
                    "url": "https://www.uniprot.org/uniprot/P09619"
                },
                {
                    "database": "PubMed",
                    "id": "21679854",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/21679854"
                },
                {
                    "database": "PubMed",
                    "id": "1653029",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/1653029"
                },
                {
                    "database": "PubMed",
                    "id": "1314164",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/1314164"
                },
                {
                    "database": "PubMed",
                    "id": "7692233",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/7692233"
                },
                {
                    "database": "PubMed",
                    "id": "10454568",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10454568"
                },
                {
                    "database": "PubMed",
                    "id": "1375321",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/1375321"
                }
            ],
            "uniprot_canonical_ac": "P09619-1"
        },
        {
            "start_pos": 771,
            "end_pos": 771,
            "sequence_org": "Y",
            "sequence_mut": "F",
            "comment": "Loss of interaction with GRB10. Abolishes interaction with RASA1. No effect on phosphatidylinositol 3-kinase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P09619",
                    "url": "https://www.uniprot.org/uniprot/P09619"
                },
                {
                    "database": "PubMed",
                    "id": "1314164",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/1314164"
                },
                {
                    "database": "PubMed",
                    "id": "10454568",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10454568"
                },
                {
                    "database": "PubMed",
                    "id": "1375321",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/1375321"
                }
            ],
            "uniprot_canonical_ac": "P09619-1"
        },
        {
            "start_pos": 857,
            "end_pos": 857,
            "sequence_org": "Y",
            "sequence_mut": "F",
            "comment": "Reduces kinase activity. No effect on interaction with GRB10. Abolishes interaction with RASA1. No effect on phosphatidylinositol 3-kinase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P09619",
                    "url": "https://www.uniprot.org/uniprot/P09619"
                },
                {
                    "database": "PubMed",
                    "id": "20494825",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/20494825"
                },
                {
                    "database": "PubMed",
                    "id": "1653029",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/1653029"
                },
                {
                    "database": "PubMed",
                    "id": "1314164",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/1314164"
                },
                {
                    "database": "PubMed",
                    "id": "10454568",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10454568"
                }
            ],
            "uniprot_canonical_ac": "P09619-1"
        },
        {
            "start_pos": 1280,
            "end_pos": 1280,
            "sequence_org": "Y",
            "sequence_mut": "F",
            "comment": "No effect on GRB10-binding.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P08069",
                    "url": "https://www.uniprot.org/uniprot/P08069"
                },
                {
                    "database": "PubMed",
                    "id": "10454568",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10454568"
                }
            ],
            "uniprot_canonical_ac": "P08069-1"
        },
        {
            "start_pos": 1281,
            "end_pos": 1281,
            "sequence_org": "Y",
            "sequence_mut": "F",
            "comment": "No effect on GRB10-binding.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P08069",
                    "url": "https://www.uniprot.org/uniprot/P08069"
                },
                {
                    "database": "PubMed",
                    "id": "10454568",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10454568"
                }
            ],
            "uniprot_canonical_ac": "P08069-1"
        },
        {
            "start_pos": 1346,
            "end_pos": 1346,
            "sequence_org": "Y",
            "sequence_mut": "F",
            "comment": "Loss of GRB10-binding.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P08069",
                    "url": "https://www.uniprot.org/uniprot/P08069"
                },
                {
                    "database": "PubMed",
                    "id": "10454568",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10454568"
                }
            ],
            "uniprot_canonical_ac": "P08069-1"
        },
        {
            "start_pos": 980,
            "end_pos": 980,
            "sequence_org": "Y",
            "sequence_mut": "F",
            "comment": "Reduces tyrosine phosphorylation. Abolishes interaction with IRS1 and SHC1. Does not abolish interaction with PIK3R1, nor with GRB10.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P08069",
                    "url": "https://www.uniprot.org/uniprot/P08069"
                },
                {
                    "database": "PubMed",
                    "id": "7541045",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/7541045"
                },
                {
                    "database": "PubMed",
                    "id": "10454568",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10454568"
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            ],
            "uniprot_canonical_ac": "P08069-1"
        }
    ],
    "phosphorylation": [
        {
            "start_pos": 771,
            "end_pos": 771,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Tyr",
            "comment": "Phosphotyrosine; by autocatalysis",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P09619",
                    "url": "https://www.uniprot.org/uniprot/P09619"
                },
                {
                    "database": "IntAct",
                    "id": "P09619",
                    "url": "https://www.ebi.ac.uk/intact/interactors/id:P09619*"
                },
                {
                    "database": "iPTMnet",
                    "id": "P09619",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P09619"
                },
                {
                    "database": "PubMed",
                    "id": "1314164",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/1314164"
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                {
                    "database": "PubMed",
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                    "database": "PubMed",
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                },
                {
                    "database": "PubMed",
                    "id": "10733900",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10733900"
                },
                {
                    "database": "PubMed",
                    "id": "8382774",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/8382774"
                },
                {
                    "database": "phospho.ELM",
                    "id": "P09619",
                    "url": "http://phospho.elm.eu.org/byAccession/P09619.html"
                },
                {
                    "database": "PubMed",
                    "id": "8195171",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/8195171"
                },
                {
                    "database": "PRO",
                    "id": "P09619",
                    "url": "http://purl.obolibrary.org/obo/P09619"
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                {
                    "database": "PubMed",
                    "id": "26631574",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/26631574"
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                {
                    "database": "PubMed",
                    "id": "33509954",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/33509954"
                },
                {
                    "database": "PubMed",
                    "id": "14966296",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/14966296"
                },
                {
                    "database": "PubMed",
                    "id": "15902258",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/15902258"
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            "site_lbl": "Tyr771",
            "uniprot_canonical_ac": "P09619-1"
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    "record_id": "pubmed.10454568",
    "abstract": "",
    "glycosylation": [],
    "snv": [],
    "glycation": [],
    "section_stats": [
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