{
    "title": "Enhanced phosphatidylinositol 3-kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation.",
    "journal": "Biochemical and biophysical research communications",
    "date": "1999",
    "authors": "Murakami H, Iwashita T, Asai N, Shimono Y, Iwata Y, Kawai K, Takahashi M",
    "reference": {
        "type": "PubMed",
        "id": "10448070",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10448070"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P56159-1",
            "protein_name": "GDNF family receptor alpha-1",
            "gene_name": "GFRA1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O60609-1",
            "protein_name": "GDNF family receptor alpha-3",
            "gene_name": "GFRA3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P17252-1",
            "protein_name": "Protein kinase C alpha type",
            "gene_name": "PRKCA",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q13322-1",
            "protein_name": "Growth factor receptor-bound protein 10",
            "gene_name": "GRB10",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O00459-1",
            "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit beta",
            "gene_name": "PIK3R2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P19174-1",
            "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1",
            "gene_name": "PLCG1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q5T4W7-1",
            "protein_name": "Artemin",
            "gene_name": "ARTN",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q8WU20-1",
            "protein_name": "Fibroblast growth factor receptor substrate 2",
            "gene_name": "FRS2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P39905-1",
            "protein_name": "Glial cell line-derived neurotrophic factor",
            "gene_name": "GDNF",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P22694-1",
            "protein_name": "cAMP-dependent protein kinase catalytic subunit beta",
            "gene_name": "PRKACB",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P07949-1",
            "protein_name": "Proto-oncogene tyrosine-protein kinase receptor Ret",
            "gene_name": "RET",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q8TEW6-1",
            "protein_name": "Docking protein 4",
            "gene_name": "DOK4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q99748-1",
            "protein_name": "Neurturin",
            "gene_name": "NRTN",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q14451-1",
            "protein_name": "Growth factor receptor-bound protein 7",
            "gene_name": "GRB7",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9Y4H2-1",
            "protein_name": "Insulin receptor substrate 2",
            "gene_name": "IRS2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P29353-1",
            "protein_name": "SHC-transforming protein 1",
            "gene_name": "SHC1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P22612-1",
            "protein_name": "cAMP-dependent protein kinase catalytic subunit gamma",
            "gene_name": "PRKACG",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P27986-1",
            "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit alpha",
            "gene_name": "PIK3R1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9UQC2-1",
            "protein_name": "GRB2-associated-binding protein 2",
            "gene_name": "GAB2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P47736-1",
            "protein_name": "Rap1 GTPase-activating protein 1",
            "gene_name": "RAP1GAP",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P42338-1",
            "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform",
            "gene_name": "PIK3CB",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O00451-1",
            "protein_name": "GDNF family receptor alpha-2",
            "gene_name": "GFRA2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P42336-1",
            "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform",
            "gene_name": "PIK3CA",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q99704-1",
            "protein_name": "Docking protein 1",
            "gene_name": "DOK1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O60542-1",
            "protein_name": "Persephin",
            "gene_name": "PSPN",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O00329-1",
            "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform",
            "gene_name": "PIK3CD",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q06124-2",
            "protein_name": "Tyrosine-protein phosphatase non-receptor type 11",
            "gene_name": "PTPN11",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9BYB0-1",
            "protein_name": "SH3 and multiple ankyrin repeat domains protein 3",
            "gene_name": "SHANK3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q92529-1",
            "protein_name": "SHC-transforming protein 3",
            "gene_name": "SHC3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q92569-1",
            "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit gamma",
            "gene_name": "PIK3R3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q07889-1",
            "protein_name": "Son of sevenless homolog 1",
            "gene_name": "SOS1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9NR12-1",
            "protein_name": "PDZ and LIM domain protein 7",
            "gene_name": "PDLIM7",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q13164-1",
            "protein_name": "Mitogen-activated protein kinase 7",
            "gene_name": "MAPK7",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9GZZ7-1",
            "protein_name": "GDNF family receptor alpha-4",
            "gene_name": "GFRA4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q13480-1",
            "protein_name": "GRB2-associated-binding protein 1",
            "gene_name": "GAB1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9P104-1",
            "protein_name": "Docking protein 5",
            "gene_name": "DOK5",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P17612-1",
            "protein_name": "cAMP-dependent protein kinase catalytic subunit alpha",
            "gene_name": "PRKACA",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q6PKX4-1",
            "protein_name": "Docking protein 6",
            "gene_name": "DOK6",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O60496-1",
            "protein_name": "Docking protein 2",
            "gene_name": "DOK2",
            "tax_name": "Human"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P56159",
                    "url": "https://www.uniprot.org/uniprot/P56159"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "record_id": "pubmed.10448070",
    "abstract": "",
    "glycosylation": [],
    "mutagenesis": [],
    "snv": [],
    "phosphorylation": [],
    "glycation": [],
    "section_stats": [
        {
            "table_id": "referenced_proteins",
            "table_stats": [
                {
                    "field": "total",
                    "count": 39
                }
            ],
            "sort_fields": [
                "uniprot_canonical_ac",
                "protein_name",
                "gene_name",
                "tax_name"
            ]
        },
        {
            "table_id": "referenced_glycans",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}
