{
    "title": "Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2.",
    "journal": "Biochemistry",
    "date": "1999",
    "authors": "Chung H, Nairn AC, Murata K, Brautigan DL",
    "reference": {
        "type": "PubMed",
        "id": "10441131",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10441131"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P62715-1",
            "protein_name": "Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform",
            "gene_name": "Ppp2cb",
            "tax_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "P63330-1",
            "protein_name": "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform",
            "gene_name": "Ppp2ca",
            "tax_name": "Mouse"
        }
    ],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P62715",
                    "url": "https://www.uniprot.org/uniprot/P62715"
                }
            ],
            "common_name": "Mouse",
            "glygen_name": "Mouse",
            "reference_species": "Mus musculus [10090]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 307,
            "end_pos": 307,
            "sequence_org": "Y",
            "sequence_mut": "Q",
            "comment": "Loss of trimeric subunit ABC assembly.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P62715",
                    "url": "https://www.uniprot.org/uniprot/P62715"
                },
                {
                    "database": "PubMed",
                    "id": "10441131",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10441131"
                }
            ],
            "uniprot_canonical_ac": "P62715-1"
        },
        {
            "start_pos": 309,
            "end_pos": 309,
            "sequence_org": "L",
            "sequence_mut": "A",
            "comment": "Loss of binding to PP2AB-alpha regulatory subunit.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P62715",
                    "url": "https://www.uniprot.org/uniprot/P62715"
                },
                {
                    "database": "PubMed",
                    "id": "10441131",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10441131"
                }
            ],
            "uniprot_canonical_ac": "P62715-1"
        },
        {
            "start_pos": 309,
            "end_pos": 309,
            "sequence_org": "L",
            "sequence_mut": "Q",
            "comment": "Loss of trimeric subunit ABC assembly.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P62715",
                    "url": "https://www.uniprot.org/uniprot/P62715"
                },
                {
                    "database": "PubMed",
                    "id": "10441131",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10441131"
                }
            ],
            "uniprot_canonical_ac": "P62715-1"
        },
        {
            "start_pos": 307,
            "end_pos": 307,
            "sequence_org": "Y",
            "sequence_mut": "Q",
            "comment": "Loss of trimeric subunit ABC assembly.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P63330",
                    "url": "https://www.uniprot.org/uniprot/P63330"
                },
                {
                    "database": "PubMed",
                    "id": "10441131",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10441131"
                }
            ],
            "uniprot_canonical_ac": "P63330-1"
        },
        {
            "start_pos": 309,
            "end_pos": 309,
            "sequence_org": "L",
            "sequence_mut": "A",
            "comment": "Loss of binding to PP2AB-alpha regulatory subunit.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P63330",
                    "url": "https://www.uniprot.org/uniprot/P63330"
                },
                {
                    "database": "PubMed",
                    "id": "10441131",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10441131"
                }
            ],
            "uniprot_canonical_ac": "P63330-1"
        }
    ],
    "record_id": "pubmed.10441131",
    "abstract": "",
    "glycosylation": [],
    "snv": [],
    "phosphorylation": [],
    "glycation": [],
    "section_stats": [
        {
            "table_id": "referenced_proteins",
            "table_stats": [
                {
                    "field": "total",
                    "count": 2
                }
            ],
            "sort_fields": [
                "uniprot_canonical_ac",
                "protein_name",
                "gene_name",
                "tax_name"
            ]
        },
        {
            "table_id": "referenced_glycans",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}
