{
    "title": "Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain.",
    "journal": "Genes to cells : devoted to molecular & cellular mechanisms",
    "date": "1999",
    "authors": "Sasaki A, Yasukawa H, Suzuki A, Kamizono S, Syoda T, Kinjyo I, Sasaki M, Johnston JA, Yoshimura A",
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        "id": "10421843",
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            "uniprot_canonical_ac": "P29350-1",
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            "uniprot_canonical_ac": "Q06124-2",
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            "tax_name": "Human"
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            "uniprot_canonical_ac": "O60674-1",
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            "uniprot_canonical_ac": "O75925-1",
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            "uniprot_canonical_ac": "P63165-1",
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        {
            "name": "Homo sapiens",
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            ],
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        {
            "start_pos": 22,
            "end_pos": 22,
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            "comment": "Little effect on EPO-induced STAT5 signaling suppression.",
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                {
                    "database": "UniProtKB",
                    "id": "O14543",
                    "url": "https://www.uniprot.org/uniprot/O14543"
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            "sequence_mut": "D",
            "comment": "Complete loss of EPO-induced STAT5 signaling suppression. No suppression of JAK2 phosphorylation.",
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                {
                    "database": "UniProtKB",
                    "id": "O14543",
                    "url": "https://www.uniprot.org/uniprot/O14543"
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                {
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            "comment": "Little effect on EPO-induced signaling suppression.",
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                {
                    "database": "PubMed",
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            ],
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        {
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            "comment": "Complete loss of EPO/LIF-induced signaling inhibition. Abolishes binding to JH1.",
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                {
                    "database": "PubMed",
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        {
            "start_pos": 45,
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            "start_pos": 71,
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            "comment": "No effect on EPO/LIF-induced signaling suppression. Partial suppression of JAK2 phosphorylation. No effect on binding to JH1. Loss of binding to IL12RB2.",
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