{
    "title": "Direct interaction of STAT4 with the IL-12 receptor.",
    "journal": "Archives of biochemistry and biophysics",
    "date": "1999",
    "authors": "Yao BB, Niu P, Surowy CS, Faltynek CR",
    "reference": {
        "type": "PubMed",
        "id": "10415122",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10415122"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P51809-1",
            "protein_name": "Vesicle-associated membrane protein 7",
            "gene_name": "VAMP7",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P29460-1",
            "protein_name": "Interleukin-12 subunit beta",
            "gene_name": "IL12B",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P42701-1",
            "protein_name": "Interleukin-12 receptor subunit beta-1",
            "gene_name": "IL12RB1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P23458-1",
            "protein_name": "Tyrosine-protein kinase JAK1",
            "gene_name": "JAK1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q14765-1",
            "protein_name": "Signal transducer and activator of transcription 4",
            "gene_name": "STAT4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P29597-1",
            "protein_name": "Non-receptor tyrosine-protein kinase TYK2",
            "gene_name": "TYK2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O60674-1",
            "protein_name": "Tyrosine-protein kinase JAK2",
            "gene_name": "JAK2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P07237-1",
            "protein_name": "Protein disulfide-isomerase",
            "gene_name": "P4HB",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P29459-1",
            "protein_name": "Interleukin-12 subunit alpha",
            "gene_name": "IL12A",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q99665-1",
            "protein_name": "Interleukin-12 receptor subunit beta-2",
            "gene_name": "IL12RB2",
            "tax_name": "Human"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P51809",
                    "url": "https://www.uniprot.org/uniprot/P51809"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 801,
            "end_pos": 801,
            "sequence_org": "L",
            "sequence_mut": "A",
            "comment": "Abolishes in vitro STAT4 binding to a phosphorylated Y-800 peptide.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q99665",
                    "url": "https://www.uniprot.org/uniprot/Q99665"
                },
                {
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                    "id": "10415122",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10415122"
                }
            ],
            "uniprot_canonical_ac": "Q99665-1"
        },
        {
            "start_pos": 802,
            "end_pos": 802,
            "sequence_org": "P",
            "sequence_mut": "A",
            "comment": "No effect on in vitro STAT4 binding to a phosphorylated Y-800 peptide.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q99665",
                    "url": "https://www.uniprot.org/uniprot/Q99665"
                },
                {
                    "database": "PubMed",
                    "id": "10415122",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10415122"
                }
            ],
            "uniprot_canonical_ac": "Q99665-1"
        },
        {
            "start_pos": 803,
            "end_pos": 803,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "No effect on in vitro STAT4 binding to a phosphorylated Y-800 peptide.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q99665",
                    "url": "https://www.uniprot.org/uniprot/Q99665"
                },
                {
                    "database": "PubMed",
                    "id": "10415122",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10415122"
                }
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            "uniprot_canonical_ac": "Q99665-1"
        },
        {
            "start_pos": 804,
            "end_pos": 804,
            "sequence_org": "N",
            "sequence_mut": "A",
            "comment": "No effect on in vitro STAT4 binding to a phosphorylated Y-800 peptide.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q99665",
                    "url": "https://www.uniprot.org/uniprot/Q99665"
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                    "database": "PubMed",
                    "id": "10415122",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10415122"
                }
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            "uniprot_canonical_ac": "Q99665-1"
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    ],
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        {
            "start_pos": 800,
            "end_pos": 800,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Tyr",
            "comment": "Phosphotyrosine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q99665",
                    "url": "https://www.uniprot.org/uniprot/Q99665"
                },
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                    "database": "PubMed",
                    "id": "10415122",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10415122"
                },
                {
                    "database": "IntAct",
                    "id": "Q99665",
                    "url": "https://www.ebi.ac.uk/intact/interactors/id:Q99665*"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q99665",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q99665"
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                    "database": "PubMed",
                    "id": "14559241",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/14559241"
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                    "database": "PubMed",
                    "id": "9890938",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/9890938"
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            ],
            "site_lbl": "Tyr800",
            "uniprot_canonical_ac": "Q99665-1"
        }
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    "record_id": "pubmed.10415122",
    "abstract": "",
    "glycosylation": [],
    "snv": [],
    "glycation": [],
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