{
    "title": "CD45 negatively regulates lyn activity by dephosphorylating both positive and negative regulatory tyrosine residues in immature B cells.",
    "journal": "Journal of immunology (Baltimore, Md. : 1950)",
    "date": "1999",
    "authors": "Katagiri T, Ogimoto M, Hasegawa K, Arimura Y, Mitomo K, Okada M, Clark MR, Mizuno K, Yakura H",
    "reference": {
        "type": "PubMed",
        "id": "10415030",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10415030"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P06800-4",
            "protein_name": "Receptor-type tyrosine-protein phosphatase C",
            "gene_name": "Ptprc",
            "tax_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "P25911-1",
            "protein_name": "Tyrosine-protein kinase Lyn",
            "gene_name": "Lyn",
            "tax_name": "Mouse"
        }
    ],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
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                    "database": "UniProtKB",
                    "id": "P06800",
                    "url": "https://www.uniprot.org/uniprot/P06800"
                }
            ],
            "common_name": "Mouse",
            "glygen_name": "Mouse",
            "reference_species": "Mus musculus [10090]"
        }
    ],
    "phosphorylation": [
        {
            "start_pos": 397,
            "end_pos": 397,
            "kinase_uniprot_canonical_ac": "P25911-1",
            "kinase_gene_name": "Lyn",
            "residue": "Tyr",
            "comment": "",
            "evidence": [
                {
                    "database": "phospho.ELM",
                    "id": "P25911",
                    "url": "http://phospho.elm.eu.org/byAccession/P25911.html"
                },
                {
                    "database": "iPTMnet",
                    "id": "P25911",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P25911"
                },
                {
                    "database": "PubMed",
                    "id": "10415030",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10415030"
                },
                {
                    "database": "UniProtKB",
                    "id": "P25911",
                    "url": "https://www.uniprot.org/uniprot/P25911"
                }
            ],
            "site_lbl": "Tyr397",
            "uniprot_canonical_ac": "P25911-1"
        },
        {
            "start_pos": 508,
            "end_pos": 508,
            "kinase_uniprot_canonical_ac": "P25911-1",
            "kinase_gene_name": "Lyn",
            "residue": "Tyr",
            "comment": "",
            "evidence": [
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                },
                {
                    "database": "iPTMnet",
                    "id": "P25911",
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                },
                {
                    "database": "PubMed",
                    "id": "10415030",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10415030"
                }
            ],
            "site_lbl": "Tyr508",
            "uniprot_canonical_ac": "P25911-1"
        },
        {
            "start_pos": 508,
            "end_pos": 508,
            "kinase_uniprot_canonical_ac": "P41241-1",
            "kinase_gene_name": "Csk",
            "residue": "Tyr",
            "comment": "",
            "evidence": [
                {
                    "database": "phospho.ELM",
                    "id": "P25911",
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                },
                {
                    "database": "iPTMnet",
                    "id": "P25911",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P25911"
                },
                {
                    "database": "PubMed",
                    "id": "10415030",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10415030"
                }
            ],
            "site_lbl": "Tyr508",
            "uniprot_canonical_ac": "P25911-1"
        },
        {
            "start_pos": 508,
            "end_pos": 508,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Tyr",
            "comment": "Phosphotyrosine; by autocatalysis, CSK and MATK",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P25911",
                    "url": "https://www.uniprot.org/uniprot/P25911"
                },
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    "abstract": "",
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    "snv": [],
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