{
    "title": "Abnormal cardiac structure and function in mice expressing nonphosphorylatable cardiac regulatory myosin light chain 2.",
    "journal": "The Journal of biological chemistry",
    "date": "1999",
    "authors": "Sanbe A, Fewell JG, Gulick J, Osinska H, Lorenz J, Hall DG, Murray LA, Kimball TR, Witt SA, Robbins J",
    "reference": {
        "type": "PubMed",
        "id": "10409661",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10409661"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P51667-1",
            "protein_name": "Myosin regulatory light chain 2, ventricular/cardiac muscle isoform",
            "gene_name": "Myl2",
            "tax_name": "Mouse"
        }
    ],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P51667",
                    "url": "https://www.uniprot.org/uniprot/P51667"
                }
            ],
            "common_name": "Mouse",
            "glygen_name": "Mouse",
            "reference_species": "Mus musculus [10090]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 14,
            "end_pos": 14,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "Loss of cardiac myofibril assembly; when associated with A-15 and A-19. Loss of phosphorylation; when associated with A-15 and A-19. Loss of calcium sensitivity of force development; when associated with A-15 and A-19. Phosphorylation at Ser-19; when associated with A-15. Significant decrease in phosphorylation by MLCK; when associated with A-15. Adult lethality associated with early defects in cardiac twitch relaxation and torsion leading to dilated cardiomyopathy, heart failure and premature death; when associated with A-15.Significant acceleration of twitch relaxation in absence of changes in calcium transients; when associated with A-15. Absence of transmural phosphorylation gradient leading to alteration of torsion; when associated with A-14.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P51667",
                    "url": "https://www.uniprot.org/uniprot/P51667"
                },
                {
                    "database": "PubMed",
                    "id": "10409661",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10409661"
                },
                {
                    "database": "PubMed",
                    "id": "22426213",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/22426213"
                }
            ],
            "uniprot_canonical_ac": "P51667-1"
        },
        {
            "start_pos": 15,
            "end_pos": 15,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "Loss of cardiac myofibril assembly; when associated with A-14 and A-19. Loss of phosphorylation; when associated with A-14 and A-19. Loss of calcium sensitivity of force development; when associated with A-14 and A-19. Increase of phosphorylation. Phosphorylation at Ser-14 and at Ser-19. Phosphorylation at Ser-19; when associated with A-14. Significant decrease in phosphorylation by MLCK; when associated with A-14. Adult lethality associated with early defects in cardiac twitch relaxation and torsion leading to dilated cardiomyopathy, heart failure and premature death; when associated with A-14. Significant acceleration of twitch relaxation in absence of changes in calcium transients; when associated with A-14. Absence of transmural phosphorylation gradient leading to alteration of torsion; when associated with A-14.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P51667",
                    "url": "https://www.uniprot.org/uniprot/P51667"
                },
                {
                    "database": "PubMed",
                    "id": "10409661",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10409661"
                },
                {
                    "database": "PubMed",
                    "id": "22426213",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/22426213"
                }
            ],
            "uniprot_canonical_ac": "P51667-1"
        },
        {
            "start_pos": 19,
            "end_pos": 19,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "Loss of cardiac myofibril assembly; when associated with A-14 and A-15. Loss of phosphorylation; when associated with A-14 and A-15. Loss of calcium sensitivity of force development; when associated with A-14 and A-15.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P51667",
                    "url": "https://www.uniprot.org/uniprot/P51667"
                },
                {
                    "database": "PubMed",
                    "id": "10409661",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10409661"
                }
            ],
            "uniprot_canonical_ac": "P51667-1"
        }
    ],
    "record_id": "pubmed.10409661",
    "abstract": "",
    "glycosylation": [],
    "snv": [],
    "phosphorylation": [],
    "glycation": [],
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