{
    "title": "Mutations in the white gene of Drosophila melanogaster affecting ABC transporters that determine eye colouration.",
    "journal": "Biochimica et biophysica acta",
    "date": "1999",
    "authors": "Mackenzie SM, Brooker MR, Gill TR, Cox GB, Howells AJ, Ewart GD",
    "reference": {
        "type": "PubMed",
        "id": "10407069",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10407069"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P12428-1",
            "protein_name": "Protein brown",
            "gene_name": "bw",
            "tax_name": "Fruit fly"
        },
        {
            "uniprot_canonical_ac": "P45843-1",
            "protein_name": "Protein scarlet",
            "gene_name": "st",
            "tax_name": "Fruit fly"
        },
        {
            "uniprot_canonical_ac": "P10090-1",
            "protein_name": "Protein white",
            "gene_name": "w",
            "tax_name": "Fruit fly"
        }
    ],
    "species": [
        {
            "name": "Drosophila melanogaster",
            "taxid": 7227,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P12428",
                    "url": "https://www.uniprot.org/uniprot/P12428"
                }
            ],
            "common_name": "Fruit fly",
            "glygen_name": "Fruit fly",
            "reference_species": "Drosophila melanogaster [7227]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 298,
            "end_pos": 298,
            "sequence_org": "H",
            "sequence_mut": "N",
            "comment": "In crr; 89% decrease in drosopterin (eye red pigment) levels and 81% decrease in xanthommatin (eye brown pigment) levels.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P10090",
                    "url": "https://www.uniprot.org/uniprot/P10090"
                },
                {
                    "database": "PubMed",
                    "id": "10407069",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10407069"
                }
            ],
            "uniprot_canonical_ac": "P10090-1"
        },
        {
            "start_pos": 49,
            "end_pos": 49,
            "sequence_org": "L",
            "sequence_mut": "R",
            "comment": "In cf; 70% decrease in drosopterin (eye red pigment) levels, 36% decrease in xanthommatin (eye brown pigment) levels and severe defect of copulation success; when associated with E-589.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P10090",
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                },
                {
                    "database": "PubMed",
                    "id": "10407069",
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                },
                {
                    "database": "PubMed",
                    "id": "28794482",
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                }
            ],
            "uniprot_canonical_ac": "P10090-1"
        },
        {
            "start_pos": 509,
            "end_pos": 509,
            "sequence_org": "G",
            "sequence_mut": "D",
            "comment": "In Et87; 98% decrease in drosopterin (eye red pigment) levels and undetectable levels of xanthommatin (eye brown pigment).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P10090",
                    "url": "https://www.uniprot.org/uniprot/P10090"
                },
                {
                    "database": "PubMed",
                    "id": "10407069",
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                }
            ],
            "uniprot_canonical_ac": "P10090-1"
        },
        {
            "start_pos": 589,
            "end_pos": 589,
            "sequence_org": "G",
            "sequence_mut": "E",
            "comment": "In cf; 70% decrease in drosopterin (eye red pigment) levels, 36% decrease in xanthommatin (eye brown pigment) levels and severe defect of copulation success; when associated with R-49.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P10090",
                    "url": "https://www.uniprot.org/uniprot/P10090"
                },
                {
                    "database": "PubMed",
                    "id": "10407069",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10407069"
                },
                {
                    "database": "PubMed",
                    "id": "28794482",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/28794482"
                }
            ],
            "uniprot_canonical_ac": "P10090-1"
        },
        {
            "start_pos": 590,
            "end_pos": 590,
            "sequence_org": "F",
            "sequence_mut": "G",
            "comment": "In sat; 96% decrease in drosopterin (eye red pigment) levels and 21% decrease in xanthommatin (eye brown pigment) levels.",
            "evidence": [
                {
                    "database": "UniProtKB",
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    "record_id": "pubmed.10407069",
    "abstract": "",
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