{
    "title": "Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis.",
    "journal": "The EMBO journal",
    "date": "1999",
    "authors": "Hu Y, Benedict MA, Ding L, Nunez G",
    "reference": {
        "type": "PubMed",
        "id": "10393175",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10393175"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P78560-1",
            "protein_name": "Death domain-containing protein CRADD",
            "gene_name": "CRADD",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P42575-1",
            "protein_name": "Caspase-2",
            "gene_name": "CASP2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q13315-1",
            "protein_name": "Serine-protein kinase ATM",
            "gene_name": "ATM",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q92851-1",
            "protein_name": "Caspase-10",
            "gene_name": "CASP10",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9NPP4-1",
            "protein_name": "NLR family CARD domain-containing protein 4",
            "gene_name": "NLRC4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P29466-1",
            "protein_name": "Caspase-1",
            "gene_name": "CASP1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O14727-1",
            "protein_name": "Apoptotic protease-activating factor 1",
            "gene_name": "APAF1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P04637-1",
            "protein_name": "Cellular tumor antigen p53",
            "gene_name": "TP53",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9H3D4-1",
            "protein_name": "Tumor protein 63",
            "gene_name": "TP63",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P55212-1",
            "protein_name": "Caspase-6",
            "gene_name": "CASP6",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9HB75-1",
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            "tax_name": "Human"
        },
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            "uniprot_canonical_ac": "O15350-1",
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        }
    ],
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            "name": "Homo sapiens",
            "taxid": 9606,
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            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 160,
            "end_pos": 160,
            "sequence_org": "K",
            "sequence_mut": "R",
            "comment": "No association with APAF-1. No binding to pro-caspase-9.",
            "evidence": [
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                    "id": "O14727",
                    "url": "https://www.uniprot.org/uniprot/O14727"
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            "uniprot_canonical_ac": "O14727-1"
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        {
            "start_pos": 368,
            "end_pos": 368,
            "sequence_org": "M",
            "sequence_mut": "L",
            "comment": "Activation of pro-caspase-9 independent of cytochrome c. Increased ability to induce apoptosis.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O14727",
                    "url": "https://www.uniprot.org/uniprot/O14727"
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    "record_id": "pubmed.10393175",
    "abstract": "",
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