{
    "title": "Hyperphosphorylation of the retinoid X receptor alpha by activated c-Jun NH2-terminal kinases.",
    "journal": "The Journal of biological chemistry",
    "date": "1999",
    "authors": "Adam-Stitah S, Penna L, Chambon P, Rochette-Egly C",
    "reference": {
        "type": "PubMed",
        "id": "10383391",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10383391"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P28700-1",
            "protein_name": "Retinoic acid receptor RXR-alpha",
            "gene_name": "Rxra",
            "tax_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "P19793-1",
            "protein_name": "Retinoic acid receptor RXR-alpha",
            "gene_name": "RXRA",
            "tax_name": "Human"
        }
    ],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P28700",
                    "url": "https://www.uniprot.org/uniprot/P28700"
                }
            ],
            "common_name": "Mouse",
            "glygen_name": "Mouse",
            "reference_species": "Mus musculus [10090]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 101,
            "end_pos": 101,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "No effect on constituitive phosphorylation.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P28700",
                    "url": "https://www.uniprot.org/uniprot/P28700"
                },
                {
                    "database": "PubMed",
                    "id": "10383391",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10383391"
                }
            ],
            "uniprot_canonical_ac": "P28700-1"
        },
        {
            "start_pos": 22,
            "end_pos": 22,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "Loss of constituitive phosphorylation. No effect on RXRA transcriptional activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P28700",
                    "url": "https://www.uniprot.org/uniprot/P28700"
                },
                {
                    "database": "PubMed",
                    "id": "10383391",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10383391"
                },
                {
                    "database": "PubMed",
                    "id": "12032153",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/12032153"
                }
            ],
            "uniprot_canonical_ac": "P28700-1"
        },
        {
            "start_pos": 265,
            "end_pos": 265,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "No effect on constiuitive phosphorylation but loss of stress-induced phosphorylation. No effect on RXRA transcriptional activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P28700",
                    "url": "https://www.uniprot.org/uniprot/P28700"
                },
                {
                    "database": "PubMed",
                    "id": "10383391",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10383391"
                }
            ],
            "uniprot_canonical_ac": "P28700-1"
        },
        {
            "start_pos": 44,
            "end_pos": 44,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "No effect on constituitive phosphorylation.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P28700",
                    "url": "https://www.uniprot.org/uniprot/P28700"
                },
                {
                    "database": "PubMed",
                    "id": "10383391",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10383391"
                }
            ],
            "uniprot_canonical_ac": "P28700-1"
        },
        {
            "start_pos": 48,
            "end_pos": 48,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "No effect on constituitive phosphorylation.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P28700",
                    "url": "https://www.uniprot.org/uniprot/P28700"
                },
                {
                    "database": "PubMed",
                    "id": "10383391",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10383391"
                }
            ],
            "uniprot_canonical_ac": "P28700-1"
        },
        {
            "start_pos": 54,
            "end_pos": 54,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "No effect on constituitive phosphorylation.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P28700",
                    "url": "https://www.uniprot.org/uniprot/P28700"
                },
                {
                    "database": "PubMed",
                    "id": "10383391",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10383391"
                }
            ],
            "uniprot_canonical_ac": "P28700-1"
        },
        {
            "start_pos": 61,
            "end_pos": 61,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "No effect on constituitive phosphorylation, decreased stress-induced phosphorylation but no effect on RXRA transcriptional activity. Abolishes stress-induced phosphorylation but no effect on RXRA transcriptional activity; when associated with A-75 and A-87. No effect on RXRA transcriptional activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P28700",
                    "url": "https://www.uniprot.org/uniprot/P28700"
                },
                {
                    "database": "PubMed",
                    "id": "10383391",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10383391"
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            ],
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        {
            "start_pos": 75,
            "end_pos": 75,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "No effect on constituitive phosphorylation, decreased stress-induced phosphorylation but no effect on RXRA transcriptional activity. Abolishes stress-induced phosphorylation but no effect on RXRA transcriptional activity; when associated with A-61 and A-87.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P28700",
                    "url": "https://www.uniprot.org/uniprot/P28700"
                },
                {
                    "database": "PubMed",
                    "id": "10383391",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10383391"
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            "uniprot_canonical_ac": "P28700-1"
        },
        {
            "start_pos": 87,
            "end_pos": 87,
            "sequence_org": "T",
            "sequence_mut": "A",
            "comment": "No effect on constituitive phosphorylation, decreased stress-induced phosphorylation but no effect on RXRA transcriptional activity. Abolishes stress-induced phosphorylation but no effect on RXRA transcriptional activity; when associated with A-61 and A-75. phosphorylation. No effect on RXRA transcriptional activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P28700",
                    "url": "https://www.uniprot.org/uniprot/P28700"
                },
                {
                    "database": "PubMed",
                    "id": "10383391",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10383391"
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            "uniprot_canonical_ac": "P28700-1"
        },
        {
            "start_pos": 96,
            "end_pos": 96,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "No effect on constituitive phosphorylation.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P28700",
                    "url": "https://www.uniprot.org/uniprot/P28700"
                },
                {
                    "database": "PubMed",
                    "id": "10383391",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10383391"
                }
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            "uniprot_canonical_ac": "P28700-1"
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            "end_pos": 22,
            "kinase_uniprot_canonical_ac": "",
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            "comment": "Phosphoserine",
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                    "database": "UniProtKB",
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                },
                {
                    "database": "PubMed",
                    "id": "10383391",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10383391"
                },
                {
                    "database": "PubMed",
                    "id": "12032153",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/12032153"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/21183079"
                },
                {
                    "database": "phospho.ELM",
                    "id": "P28700",
                    "url": "http://phospho.elm.eu.org/byAccession/P28700.html"
                },
                {
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                    "id": "P28700",
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                }
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            "start_pos": 265,
            "end_pos": 265,
            "kinase_uniprot_canonical_ac": "Q91Y86-1",
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                {
                    "database": "PubMed",
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                    "url": "https://pubmed.ncbi.nlm.nih.gov/10383391"
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            "uniprot_canonical_ac": "P28700-1"
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        {
            "start_pos": 265,
            "end_pos": 265,
            "kinase_uniprot_canonical_ac": "Q9WTU6-1",
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                {
                    "database": "PubMed",
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            "site_lbl": "Ser265",
            "uniprot_canonical_ac": "P28700-1"
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        {
            "start_pos": 265,
            "end_pos": 265,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
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            "comment": "Phosphoserine; by MAPK8 and MAPK9",
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                {
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            "site_lbl": "Ser265",
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        {
            "start_pos": 61,
            "end_pos": 61,
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            "comment": "",
            "evidence": [
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                {
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                    "url": "https://pubmed.ncbi.nlm.nih.gov/10383391"
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            ],
            "site_lbl": "Ser61",
            "uniprot_canonical_ac": "P28700-1"
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        {
            "start_pos": 61,
            "end_pos": 61,
            "kinase_uniprot_canonical_ac": "Q9WTU6-1",
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            "evidence": [
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                {
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                    "url": "https://pubmed.ncbi.nlm.nih.gov/10383391"
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            ],
            "site_lbl": "Ser61",
            "uniprot_canonical_ac": "P28700-1"
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        {
            "start_pos": 61,
            "end_pos": 61,
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            "kinase_gene_name": "",
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                {
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                {
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            "start_pos": 75,
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                {
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        {
            "start_pos": 75,
            "end_pos": 75,
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            "kinase_gene_name": "",
            "residue": "Ser",
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                {
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            "start_pos": 87,
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            "evidence": [
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                    "database": "iPTMnet",
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