{
    "title": "Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42.",
    "journal": "The Journal of biological chemistry",
    "date": "1999",
    "authors": "Perez RG, Soriano S, Hayes JD, Ostaszewski B, Xia W, Selkoe DJ, Chen X, Stokin GB, Koo EH",
    "reference": {
        "type": "PubMed",
        "id": "10383380",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10383380"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P05067-1",
            "protein_name": "Amyloid-beta precursor protein",
            "gene_name": "APP",
            "tax_name": "Human"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05067",
                    "url": "https://www.uniprot.org/uniprot/P05067"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 728,
            "end_pos": 728,
            "sequence_org": "Y",
            "sequence_mut": "A",
            "comment": "No effect on APBA1 nor APBB1 binding. Greatly reduces the binding to APPBP2. APP internalization unchanged. No change in amyloid-beta protein 42 secretion.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05067",
                    "url": "https://www.uniprot.org/uniprot/P05067"
                },
                {
                    "database": "PubMed",
                    "id": "9843960",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/9843960"
                },
                {
                    "database": "PubMed",
                    "id": "10383380",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10383380"
                },
                {
                    "database": "PubMed",
                    "id": "8887653",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/8887653"
                }
            ],
            "uniprot_canonical_ac": "P05067-1"
        },
        {
            "start_pos": 756,
            "end_pos": 756,
            "sequence_org": "G",
            "sequence_mut": "A",
            "comment": "APP internalization unchanged. No change in amyloid-beta protein 42 secretion.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05067",
                    "url": "https://www.uniprot.org/uniprot/P05067"
                },
                {
                    "database": "PubMed",
                    "id": "10383380",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10383380"
                }
            ],
            "uniprot_canonical_ac": "P05067-1"
        },
        {
            "start_pos": 757,
            "end_pos": 757,
            "sequence_org": "Y",
            "sequence_mut": "A",
            "comment": "Little APP internalization. Reduced amyloid-beta protein 42 secretion.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05067",
                    "url": "https://www.uniprot.org/uniprot/P05067"
                },
                {
                    "database": "PubMed",
                    "id": "10383380",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10383380"
                },
                {
                    "database": "PubMed",
                    "id": "11724784",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11724784"
                },
                {
                    "database": "PubMed",
                    "id": "8887653",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/8887653"
                },
                {
                    "database": "PubMed",
                    "id": "11877420",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11877420"
                }
            ],
            "uniprot_canonical_ac": "P05067-1"
        },
        {
            "start_pos": 757,
            "end_pos": 757,
            "sequence_org": "Y",
            "sequence_mut": "G",
            "comment": "Loss of binding to MAPK8IP1, APBA1, APBB1, APPBP2 and SHC1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05067",
                    "url": "https://www.uniprot.org/uniprot/P05067"
                },
                {
                    "database": "PubMed",
                    "id": "10383380",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10383380"
                },
                {
                    "database": "PubMed",
                    "id": "11724784",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11724784"
                },
                {
                    "database": "PubMed",
                    "id": "8887653",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/8887653"
                },
                {
                    "database": "PubMed",
                    "id": "11877420",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11877420"
                }
            ],
            "uniprot_canonical_ac": "P05067-1"
        },
        {
            "start_pos": 759,
            "end_pos": 759,
            "sequence_org": "N",
            "sequence_mut": "A",
            "comment": "No binding to APBA1, no effect on APBB1 binding. Little APP internalization. Reduced amyloid-beta protein 42 secretion.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05067",
                    "url": "https://www.uniprot.org/uniprot/P05067"
                },
                {
                    "database": "PubMed",
                    "id": "10383380",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10383380"
                },
                {
                    "database": "PubMed",
                    "id": "8887653",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/8887653"
                }
            ],
            "uniprot_canonical_ac": "P05067-1"
        },
        {
            "start_pos": 760,
            "end_pos": 760,
            "sequence_org": "P",
            "sequence_mut": "A",
            "comment": "Little APP internalization. Reduced amyloid-beta protein 42 secretion.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05067",
                    "url": "https://www.uniprot.org/uniprot/P05067"
                },
                {
                    "database": "PubMed",
                    "id": "10383380",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10383380"
                }
            ],
            "uniprot_canonical_ac": "P05067-1"
        },
        {
            "start_pos": 762,
            "end_pos": 762,
            "sequence_org": "Y",
            "sequence_mut": "A",
            "comment": "Loss of binding to APBA1 and APBB1. APP internalization unchanged. No change in amyloid-beta protein 42 secretion.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05067",
                    "url": "https://www.uniprot.org/uniprot/P05067"
                },
                {
                    "database": "PubMed",
                    "id": "10383380",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10383380"
                },
                {
                    "database": "PubMed",
                    "id": "8887653",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/8887653"
                }
            ],
            "uniprot_canonical_ac": "P05067-1"
        }
    ],
    "record_id": "pubmed.10383380",
    "abstract": "",
    "glycosylation": [],
    "snv": [],
    "phosphorylation": [],
    "glycation": [],
    "section_stats": [
        {
            "table_id": "referenced_proteins",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "uniprot_canonical_ac",
                "protein_name",
                "gene_name",
                "tax_name"
            ]
        },
        {
            "table_id": "referenced_glycans",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}