{
    "title": "Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity.",
    "journal": "Biochem. Biophys. Res. Commun.",
    "date": "1999",
    "authors": "Frye RA",
    "reference": {
        "type": "PubMed",
        "id": "10381378",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10381378"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "Q9Y6E7-1",
            "protein_name": "NAD-dependent protein lipoamidase sirtuin-4, mitochondrial",
            "gene_name": "SIRT4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q8IXJ6-1",
            "protein_name": "NAD-dependent protein deacetylase sirtuin-2",
            "gene_name": "SIRT2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q96EB6-1",
            "protein_name": "NAD-dependent protein deacetylase sirtuin-1",
            "gene_name": "SIRT1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9NXA8-1",
            "protein_name": "NAD-dependent protein deacylase sirtuin-5, mitochondrial",
            "gene_name": "SIRT5",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9NTG7-1",
            "protein_name": "NAD-dependent protein deacetylase sirtuin-3, mitochondrial",
            "gene_name": "SIRT3",
            "tax_name": "Human"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Y6E7",
                    "url": "https://www.uniprot.org/uniprot/Q9Y6E7"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "mutagenesis": [
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            "start_pos": 187,
            "end_pos": 187,
            "sequence_org": "H",
            "sequence_mut": "A",
            "comment": "Inhibits deacetylase activity toward histone, alpha-tubulin, FZR1 and CDC20. No effect on CDK2-dependent phosphorylation. Does not inhibit interaction with alpha-tubulin, HDAC6, HIF1A and the cyclin E-CDK2 complex. Inhibits interaction with BEX4 and KMT5A. Abolishes deacetylation, dimeric formation and enzymatic activity increase of G6PD. Prevents histone H4 methylation at 'Lys-20'(H4K20me1) in metaphase chromosomes. Inhibits the block of entry to chromosome condensation and subsequent hyperploidy cell formation in response to mitotic stress; when associated with A-167 and A-168. Strongly reduced activity toward long-chain fatty acyl groups.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8IXJ6",
                    "url": "https://www.uniprot.org/uniprot/Q8IXJ6"
                },
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                    "database": "PubMed",
                    "id": "24681946",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/24681946"
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                    "url": "https://pubmed.ncbi.nlm.nih.gov/22014574"
                },
                {
                    "database": "PubMed",
                    "id": "11427894",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11427894"
                },
                {
                    "database": "PubMed",
                    "id": "16909107",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/16909107"
                },
                {
                    "database": "PubMed",
                    "id": "27512957",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/27512957"
                },
                {
                    "database": "PubMed",
                    "id": "12620231",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/12620231"
                },
                {
                    "database": "PubMed",
                    "id": "29239724",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/29239724"
                },
                {
                    "database": "PubMed",
                    "id": "11812793",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11812793"
                },
                {
                    "database": "PubMed",
                    "id": "17488717",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/17488717"
                },
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                    "id": "12697818",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/12697818"
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            ],
            "uniprot_canonical_ac": "Q8IXJ6-1"
        },
        {
            "start_pos": 187,
            "end_pos": 187,
            "sequence_org": "H",
            "sequence_mut": "Y",
            "comment": "Inhibits deacetylase activity toward histone, alpha-tubulin, FZR1 and CDC20. No effect on CDK2-dependent phosphorylation. Does not inhibit interaction with alpha-tubulin, HDAC6, HIF1A and the cyclin E-CDK2 complex. Inhibits interaction with BEX4 and KMT5A. Abolishes deacetylation, dimeric formation and enzymatic activity increase of G6PD. Prevents histone H4 methylation at 'Lys-20'(H4K20me1) in metaphase chromosomes. Inhibits the block of entry to chromosome condensation and subsequent hyperploidy cell formation in response to mitotic stress; when associated with A-167 and A-168. Strongly reduced activity toward long-chain fatty acyl groups.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8IXJ6",
                    "url": "https://www.uniprot.org/uniprot/Q8IXJ6"
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                {
                    "database": "PubMed",
                    "id": "24681946",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/24681946"
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                    "database": "PubMed",
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                    "url": "https://pubmed.ncbi.nlm.nih.gov/17516032"
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                    "database": "PubMed",
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                },
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                    "database": "PubMed",
                    "id": "22014574",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/22014574"
                },
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                    "id": "11427894",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11427894"
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                    "database": "PubMed",
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                    "url": "https://pubmed.ncbi.nlm.nih.gov/16909107"
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                    "database": "PubMed",
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                    "database": "PubMed",
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                    "url": "https://pubmed.ncbi.nlm.nih.gov/11812793"
                },
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                    "id": "17488717",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/17488717"
                },
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    "record_id": "pubmed.10381378",
    "abstract": "",
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