{
    "title": "Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1.",
    "journal": "Proceedings of the National Academy of Sciences of the United States of America",
    "date": "1999",
    "authors": "Biggs WH 3rd, Meisenhelder J, Hunter T, Cavenee WK, Arden KC",
    "reference": {
        "type": "PubMed",
        "id": "10377430",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10377430"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "Q12778-1",
            "protein_name": "Forkhead box protein O1",
            "gene_name": "FOXO1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9R1E0-1",
            "protein_name": "Forkhead box protein O1",
            "gene_name": "Foxo1",
            "tax_name": "Mouse"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12778",
                    "url": "https://www.uniprot.org/uniprot/Q12778"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "phosphorylation": [
        {
            "start_pos": 24,
            "end_pos": 24,
            "kinase_uniprot_canonical_ac": "P31751-1",
            "kinase_gene_name": "AKT2",
            "residue": "Thr",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "Q12778",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12778"
                },
                {
                    "database": "PubMed",
                    "id": "10377430",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10377430"
                }
            ],
            "site_lbl": "Thr24",
            "uniprot_canonical_ac": "Q12778-1"
        },
        {
            "start_pos": 256,
            "end_pos": 256,
            "kinase_uniprot_canonical_ac": "P31751-1",
            "kinase_gene_name": "AKT2",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "Q12778",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12778"
                },
                {
                    "database": "PubMed",
                    "id": "10377430",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10377430"
                }
            ],
            "site_lbl": "Ser256",
            "uniprot_canonical_ac": "Q12778-1"
        },
        {
            "start_pos": 24,
            "end_pos": 24,
            "kinase_uniprot_canonical_ac": "P31750-1",
            "kinase_gene_name": "Akt1",
            "residue": "Thr",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "Q9R1E0",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9R1E0"
                },
                {
                    "database": "PubMed",
                    "id": "10377430",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10377430"
                },
                {
                    "database": "PubMed",
                    "id": "11570877",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11570877"
                }
            ],
            "site_lbl": "Thr24",
            "uniprot_canonical_ac": "Q9R1E0-1"
        },
        {
            "start_pos": 24,
            "end_pos": 24,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine; by PKB/AKT1 or PKB/AKT2 and SGK1",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9R1E0",
                    "url": "https://www.uniprot.org/uniprot/Q9R1E0"
                },
                {
                    "database": "phospho.ELM",
                    "id": "Q9R1E0",
                    "url": "http://phospho.elm.eu.org/byAccession/Q9R1E0.html"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q9R1E0",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9R1E0"
                },
                {
                    "database": "PubMed",
                    "id": "10377430",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10377430"
                },
                {
                    "database": "PubMed",
                    "id": "24466179",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/24466179"
                },
                {
                    "database": "PubMed",
                    "id": "28267764",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/28267764"
                },
                {
                    "database": "PubMed",
                    "id": "30174230",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/30174230"
                },
                {
                    "database": "PubMed",
                    "id": "33138208",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/33138208"
                },
                {
                    "database": "PubMed",
                    "id": "19965929",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/19965929"
                },
                {
                    "database": "PubMed",
                    "id": "20519497",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/20519497"
                },
                {
                    "database": "PubMed",
                    "id": "10347145",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10347145"
                }
            ],
            "site_lbl": "Thr24",
            "uniprot_canonical_ac": "Q9R1E0-1"
        },
        {
            "start_pos": 253,
            "end_pos": 253,
            "kinase_uniprot_canonical_ac": "P31750-1",
            "kinase_gene_name": "Akt1",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "Q9R1E0",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9R1E0"
                },
                {
                    "database": "PubMed",
                    "id": "10377430",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10377430"
                },
                {
                    "database": "PubMed",
                    "id": "11375271",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11375271"
                }
            ],
            "site_lbl": "Ser253",
            "uniprot_canonical_ac": "Q9R1E0-1"
        },
        {
            "start_pos": 253,
            "end_pos": 253,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine; by PKB/AKT1 and SGK1",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9R1E0",
                    "url": "https://www.uniprot.org/uniprot/Q9R1E0"
                },
                {
                    "database": "phospho.ELM",
                    "id": "Q9R1E0",
                    "url": "http://phospho.elm.eu.org/byAccession/Q9R1E0.html"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q9R1E0",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9R1E0"
                },
                {
                    "database": "PubMed",
                    "id": "10377430",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10377430"
                },
                {
                    "database": "PubMed",
                    "id": "22532369",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/22532369"
                },
                {
                    "database": "PubMed",
                    "id": "23705021",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/23705021"
                },
                {
                    "database": "PubMed",
                    "id": "24116102",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/24116102"
                },
                {
                    "database": "PubMed",
                    "id": "28270438",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/28270438"
                },
                {
                    "database": "PubMed",
                    "id": "28644433",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/28644433"
                },
                {
                    "database": "PubMed",
                    "id": "30014903",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/30014903"
                },
                {
                    "database": "PubMed",
                    "id": "16076959",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/16076959"
                },
                {
                    "database": "PubMed",
                    "id": "18388859",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/18388859"
                },
                {
                    "database": "PubMed",
                    "id": "19965929",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/19965929"
                },
                {
                    "database": "PubMed",
                    "id": "20519497",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/20519497"
                },
                {
                    "database": "PubMed",
                    "id": "27827363",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/27827363"
                },
                {
                    "database": "PubMed",
                    "id": "10347145",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10347145"
                }
            ],
            "site_lbl": "Ser253",
            "uniprot_canonical_ac": "Q9R1E0-1"
        }
    ],
    "record_id": "pubmed.10377430",
    "abstract": "",
    "glycosylation": [],
    "mutagenesis": [],
    "snv": [],
    "glycation": [],
    "section_stats": [
        {
            "table_id": "referenced_proteins",
            "table_stats": [
                {
                    "field": "total",
                    "count": 2
                }
            ],
            "sort_fields": [
                "uniprot_canonical_ac",
                "protein_name",
                "gene_name",
                "tax_name"
            ]
        },
        {
            "table_id": "referenced_glycans",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 6
                },
                {
                    "field": "total_sites",
                    "count": 3
                }
            ],
            "sort_fields": [
                "start_pos",
                "end_pos",
                "kinase_uniprot_canonical_ac",
                "kinase_gene_name",
                "residue",
                "comment",
                "site_lbl",
                "uniprot_canonical_ac"
            ]
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}
