{
    "title": "Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor.",
    "journal": "The Biochemical journal",
    "date": "1999",
    "authors": "Thommes K, Lennartsson J, Carlberg M, Ronnstrand L",
    "reference": {
        "type": "PubMed",
        "id": "10377264",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10377264"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "Q13588-1",
            "protein_name": "GRB2-related adapter protein",
            "gene_name": "GRAP",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q92729-1",
            "protein_name": "Receptor-type tyrosine-protein phosphatase U",
            "gene_name": "PTPRU",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P17252-1",
            "protein_name": "Protein kinase C alpha type",
            "gene_name": "PRKCA",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q13322-1",
            "protein_name": "Growth factor receptor-bound protein 10",
            "gene_name": "GRB10",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O00459-1",
            "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit beta",
            "gene_name": "PIK3R2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P01112-1",
            "protein_name": "GTPase HRas",
            "gene_name": "HRAS",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q60631-1",
            "protein_name": "Growth factor receptor-bound protein 2",
            "gene_name": "Grb2",
            "tax_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "P06239-1",
            "protein_name": "Tyrosine-protein kinase Lck",
            "gene_name": "LCK",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q14451-1",
            "protein_name": "Growth factor receptor-bound protein 7",
            "gene_name": "GRB7",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P27986-1",
            "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit alpha",
            "gene_name": "PIK3R1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q03160-1",
            "protein_name": "Growth factor receptor-bound protein 7",
            "gene_name": "Grb7",
            "tax_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q9UQC2-1",
            "protein_name": "GRB2-associated-binding protein 2",
            "gene_name": "GAB2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O75791-1",
            "protein_name": "GRB2-related adapter protein 2",
            "gene_name": "GRAP2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P51692-1",
            "protein_name": "Signal transducer and activator of transcription 5B",
            "gene_name": "STAT5B",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P06241-1",
            "protein_name": "Tyrosine-protein kinase Fyn",
            "gene_name": "FYN",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P23946-1",
            "protein_name": "Chymase",
            "gene_name": "CMA1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P07332-1",
            "protein_name": "Tyrosine-protein kinase Fes/Fps",
            "gene_name": "FES",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P42336-1",
            "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform",
            "gene_name": "PIK3CA",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P42229-1",
            "protein_name": "Signal transducer and activator of transcription 5A",
            "gene_name": "STAT5A",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P42224-1",
            "protein_name": "Signal transducer and activator of transcription 1-alpha/beta",
            "gene_name": "STAT1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q06124-2",
            "protein_name": "Tyrosine-protein phosphatase non-receptor type 11",
            "gene_name": "PTPN11",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q92569-1",
            "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit gamma",
            "gene_name": "PIK3R3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O60674-1",
            "protein_name": "Tyrosine-protein kinase JAK2",
            "gene_name": "JAK2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q07889-1",
            "protein_name": "Son of sevenless homolog 1",
            "gene_name": "SOS1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P40763-1",
            "protein_name": "Signal transducer and activator of transcription 3",
            "gene_name": "STAT3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P42680-1",
            "protein_name": "Tyrosine-protein kinase Tec",
            "gene_name": "TEC",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P07947-1",
            "protein_name": "Tyrosine-protein kinase Yes",
            "gene_name": "YES1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P16591-1",
            "protein_name": "Tyrosine-protein kinase Fer",
            "gene_name": "FER",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O14757-1",
            "protein_name": "Serine/threonine-protein kinase Chk1",
            "gene_name": "CHEK1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P14780-1",
            "protein_name": "Matrix metalloproteinase-9",
            "gene_name": "MMP9",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P01111-1",
            "protein_name": "GTPase NRas",
            "gene_name": "NRAS",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P15498-1",
            "protein_name": "Proto-oncogene vav",
            "gene_name": "VAV1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P07948-1",
            "protein_name": "Tyrosine-protein kinase Lyn",
            "gene_name": "LYN",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P10721-1",
            "protein_name": "Mast/stem cell growth factor receptor Kit",
            "gene_name": "KIT",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P63000-1",
            "protein_name": "Ras-related C3 botulinum toxin substrate 1",
            "gene_name": "RAC1",
            "tax_name": "Human"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q13588",
                    "url": "https://www.uniprot.org/uniprot/Q13588"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "phosphorylation": [
        {
            "start_pos": 703,
            "end_pos": 703,
            "kinase_uniprot_canonical_ac": "P10721-1",
            "kinase_gene_name": "KIT",
            "residue": "Tyr",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P10721",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10721"
                },
                {
                    "database": "PubMed",
                    "id": "10377264",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10377264"
                },
                {
                    "database": "PubMed",
                    "id": "17904548",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/17904548"
                },
                {
                    "database": "PubMed",
                    "id": "19049823",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/19049823"
                },
                {
                    "database": "PubMed",
                    "id": "19265199",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/19265199"
                },
                {
                    "database": "PubMed",
                    "id": "20147452",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/20147452"
                },
                {
                    "database": "phospho.ELM",
                    "id": "P10721",
                    "url": "http://phospho.elm.eu.org/byAccession/P10721.html"
                },
                {
                    "database": "PubMed",
                    "id": "16740725",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/16740725"
                },
                {
                    "database": "UniProtKB",
                    "id": "P10721",
                    "url": "https://www.uniprot.org/uniprot/P10721"
                }
            ],
            "site_lbl": "Tyr703",
            "uniprot_canonical_ac": "P10721-1"
        },
        {
            "start_pos": 703,
            "end_pos": 703,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Tyr",
            "comment": "Phosphotyrosine; by autocatalysis",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P10721",
                    "url": "https://www.uniprot.org/uniprot/P10721"
                },
                {
                    "database": "IntAct",
                    "id": "P10721",
                    "url": "https://www.ebi.ac.uk/intact/interactors/id:P10721*"
                },
                {
                    "database": "iPTMnet",
                    "id": "P10721",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10721"
                },
                {
                    "database": "PubMed",
                    "id": "10377264",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10377264"
                },
                {
                    "database": "PRO",
                    "id": "P10721",
                    "url": "http://purl.obolibrary.org/obo/P10721"
                },
                {
                    "database": "PubMed",
                    "id": "15007386",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/15007386"
                },
                {
                    "database": "PubMed",
                    "id": "21887372",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/21887372"
                },
                {
                    "database": "PubMed",
                    "id": "26498480",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/26498480"
                },
                {
                    "database": "PubMed",
                    "id": "28403213",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/28403213"
                },
                {
                    "database": "PubMed",
                    "id": "30242244",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/30242244"
                },
                {
                    "database": "PubMed",
                    "id": "31484543",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/31484543"
                },
                {
                    "database": "PubMed",
                    "id": "31857719",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/31857719"
                },
                {
                    "database": "PubMed",
                    "id": "19265199",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/19265199"
                },
                {
                    "database": "PubMed",
                    "id": "20147452",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/20147452"
                }
            ],
            "site_lbl": "Tyr703",
            "uniprot_canonical_ac": "P10721-1"
        },
        {
            "start_pos": 936,
            "end_pos": 936,
            "kinase_uniprot_canonical_ac": "P10721-1",
            "kinase_gene_name": "KIT",
            "residue": "Tyr",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "P10721",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10721"
                },
                {
                    "database": "PubMed",
                    "id": "10377264",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10377264"
                },
                {
                    "database": "PubMed",
                    "id": "17904548",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/17904548"
                },
                {
                    "database": "PubMed",
                    "id": "19049823",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/19049823"
                },
                {
                    "database": "PubMed",
                    "id": "19265199",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/19265199"
                },
                {
                    "database": "phospho.ELM",
                    "id": "P10721",
                    "url": "http://phospho.elm.eu.org/byAccession/P10721.html"
                },
                {
                    "database": "UniProtKB",
                    "id": "P10721",
                    "url": "https://www.uniprot.org/uniprot/P10721"
                }
            ],
            "site_lbl": "Tyr936",
            "uniprot_canonical_ac": "P10721-1"
        },
        {
            "start_pos": 936,
            "end_pos": 936,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Tyr",
            "comment": "Phosphotyrosine; by autocatalysis",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P10721",
                    "url": "https://www.uniprot.org/uniprot/P10721"
                },
                {
                    "database": "IntAct",
                    "id": "P10721",
                    "url": "https://www.ebi.ac.uk/intact/interactors/id:P10721*"
                },
                {
                    "database": "iPTMnet",
                    "id": "P10721",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P10721"
                },
                {
                    "database": "PubMed",
                    "id": "10377264",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10377264"
                },
                {
                    "database": "PubMed",
                    "id": "7537096",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/7537096"
                },
                {
                    "database": "phospho.ELM",
                    "id": "P10721",
                    "url": "http://phospho.elm.eu.org/byAccession/P10721.html"
                },
                {
                    "database": "PubMed",
                    "id": "18083107",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/18083107"
                },
                {
                    "database": "PRO",
                    "id": "P10721",
                    "url": "http://purl.obolibrary.org/obo/P10721"
                },
                {
                    "database": "PubMed",
                    "id": "12444928",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/12444928"
                },
                {
                    "database": "PubMed",
                    "id": "16780420",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/16780420"
                },
                {
                    "database": "PubMed",
                    "id": "21887372",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/21887372"
                },
                {
                    "database": "PubMed",
                    "id": "24465823",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/24465823"
                },
                {
                    "database": "PubMed",
                    "id": "28403213",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/28403213"
                },
                {
                    "database": "PubMed",
                    "id": "19265199",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/19265199"
                }
            ],
            "site_lbl": "Tyr936",
            "uniprot_canonical_ac": "P10721-1"
        }
    ],
    "record_id": "pubmed.10377264",
    "abstract": "",
    "glycosylation": [],
    "mutagenesis": [],
    "snv": [],
    "glycation": [],
    "section_stats": [
        {
            "table_id": "referenced_proteins",
            "table_stats": [
                {
                    "field": "total",
                    "count": 35
                }
            ],
            "sort_fields": [
                "uniprot_canonical_ac",
                "protein_name",
                "gene_name",
                "tax_name"
            ]
        },
        {
            "table_id": "referenced_glycans",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 4
                },
                {
                    "field": "total_sites",
                    "count": 2
                }
            ],
            "sort_fields": [
                "start_pos",
                "end_pos",
                "kinase_uniprot_canonical_ac",
                "kinase_gene_name",
                "residue",
                "comment",
                "site_lbl",
                "uniprot_canonical_ac"
            ]
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}