{
    "title": "A conserved RGD (Arg-Gly-Asp) motif in the transferrin receptor is required for binding to transferrin.",
    "journal": "The Biochemical journal",
    "date": "1999",
    "authors": "Dubljevic V, Sali A, Goding JW",
    "reference": {
        "type": "PubMed",
        "id": "10377239",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10377239"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P02786-1",
            "protein_name": "Transferrin receptor protein 1",
            "gene_name": "TFRC",
            "tax_name": "Human"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P02786",
                    "url": "https://www.uniprot.org/uniprot/P02786"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 646,
            "end_pos": 646,
            "sequence_org": "R",
            "sequence_mut": "A",
            "comment": "No binding to transferrin.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P02786",
                    "url": "https://www.uniprot.org/uniprot/P02786"
                },
                {
                    "database": "PubMed",
                    "id": "10377239",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10377239"
                }
            ],
            "uniprot_canonical_ac": "P02786-1"
        },
        {
            "start_pos": 646,
            "end_pos": 646,
            "sequence_org": "R",
            "sequence_mut": "H",
            "comment": "No binding to transferrin.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P02786",
                    "url": "https://www.uniprot.org/uniprot/P02786"
                },
                {
                    "database": "PubMed",
                    "id": "10377239",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10377239"
                }
            ],
            "uniprot_canonical_ac": "P02786-1"
        },
        {
            "start_pos": 646,
            "end_pos": 646,
            "sequence_org": "R",
            "sequence_mut": "K",
            "comment": "5% binding to transferrin.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P02786",
                    "url": "https://www.uniprot.org/uniprot/P02786"
                },
                {
                    "database": "PubMed",
                    "id": "10377239",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10377239"
                }
            ],
            "uniprot_canonical_ac": "P02786-1"
        },
        {
            "start_pos": 647,
            "end_pos": 647,
            "sequence_org": "G",
            "sequence_mut": "A",
            "comment": "Large effect on affinity for transferrin. 4-fold reduced affinity for HFE.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P02786",
                    "url": "https://www.uniprot.org/uniprot/P02786"
                },
                {
                    "database": "PubMed",
                    "id": "10377239",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10377239"
                }
            ],
            "uniprot_canonical_ac": "P02786-1"
        },
        {
            "start_pos": 648,
            "end_pos": 648,
            "sequence_org": "D",
            "sequence_mut": "A",
            "comment": "16% binding to transferrin.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P02786",
                    "url": "https://www.uniprot.org/uniprot/P02786"
                },
                {
                    "database": "PubMed",
                    "id": "10377239",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10377239"
                }
            ],
            "uniprot_canonical_ac": "P02786-1"
        },
        {
            "start_pos": 648,
            "end_pos": 648,
            "sequence_org": "D",
            "sequence_mut": "E",
            "comment": "57% binding to transferrin.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P02786",
                    "url": "https://www.uniprot.org/uniprot/P02786"
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                }
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            "uniprot_canonical_ac": "P02786-1"
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    "record_id": "pubmed.10377239",
    "abstract": "",
    "glycosylation": [],
    "snv": [],
    "phosphorylation": [],
    "glycation": [],
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