{
    "title": "Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence.",
    "journal": "The Journal of biological chemistry",
    "date": "1999",
    "authors": "Guo S, Rena G, Cichy S, He X, Cohen P, Unterman T",
    "reference": {
        "type": "PubMed",
        "id": "10358076",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10358076"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "Q12778-1",
            "protein_name": "Forkhead box protein O1",
            "gene_name": "FOXO1",
            "tax_name": "Human"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12778",
                    "url": "https://www.uniprot.org/uniprot/Q12778"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "phosphorylation": [
        {
            "start_pos": 256,
            "end_pos": 256,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine; by PKB/AKT1 and SGK1",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12778",
                    "url": "https://www.uniprot.org/uniprot/Q12778"
                },
                {
                    "database": "phospho.ELM",
                    "id": "Q12778",
                    "url": "http://phospho.elm.eu.org/byAccession/Q12778.html"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q12778",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q12778"
                },
                {
                    "database": "PubMed",
                    "id": "10358014",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10358014"
                },
                {
                    "database": "PubMed",
                    "id": "11410590",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11410590"
                },
                {
                    "database": "PRO",
                    "id": "Q12778",
                    "url": "http://purl.obolibrary.org/obo/Q12778"
                },
                {
                    "database": "PubMed",
                    "id": "10358075",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10358075"
                },
                {
                    "database": "PubMed",
                    "id": "10358076",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10358076"
                },
                {
                    "database": "PubMed",
                    "id": "11980723",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11980723"
                },
                {
                    "database": "PubMed",
                    "id": "12228231",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/12228231"
                },
                {
                    "database": "PubMed",
                    "id": "14664696",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/14664696"
                },
                {
                    "database": "PubMed",
                    "id": "14727512",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/14727512"
                },
                {
                    "database": "PubMed",
                    "id": "15353558",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/15353558"
                },
                {
                    "database": "PubMed",
                    "id": "15457186",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/15457186"
                },
                {
                    "database": "PubMed",
                    "id": "16006742",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/16006742"
                },
                {
                    "database": "PubMed",
                    "id": "16157701",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/16157701"
                },
                {
                    "database": "PubMed",
                    "id": "16203862",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/16203862"
                },
                {
                    "database": "PubMed",
                    "id": "16670089",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/16670089"
                },
                {
                    "database": "PubMed",
                    "id": "17596878",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/17596878"
                },
                {
                    "database": "PubMed",
                    "id": "18226221",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/18226221"
                },
                {
                    "database": "PubMed",
                    "id": "18319717",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/18319717"
                },
                {
                    "database": "PubMed",
                    "id": "18644889",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/18644889"
                },
                {
                    "database": "PubMed",
                    "id": "20357092",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/20357092"
                },
                {
                    "database": "PubMed",
                    "id": "20596890",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/20596890"
                },
                {
                    "database": "PubMed",
                    "id": "20685959",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/20685959"
                },
                {
                    "database": "PubMed",
                    "id": "21148296",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/21148296"
                },
                {
                    "database": "PubMed",
                    "id": "21177856",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/21177856"
                },
                {
                    "database": "PubMed",
                    "id": "22928011",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/22928011"
                },
                {
                    "database": "PubMed",
                    "id": "23099444",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/23099444"
                },
                {
                    "database": "PubMed",
                    "id": "24112473",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/24112473"
                },
                {
                    "database": "PubMed",
                    "id": "24452601",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/24452601"
                },
                {
                    "database": "PubMed",
                    "id": "24525530",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/24525530"
                },
                {
                    "database": "PubMed",
                    "id": "24556689",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/24556689"
                },
                {
                    "database": "PubMed",
                    "id": "24843827",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/24843827"
                },
                {
                    "database": "PubMed",
                    "id": "24886245",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/24886245"
                },
                {
                    "database": "PubMed",
                    "id": "25136826",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/25136826"
                },
                {
                    "database": "PubMed",
                    "id": "26600389",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/26600389"
                },
                {
                    "database": "PubMed",
                    "id": "26879559",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/26879559"
                },
                {
                    "database": "PubMed",
                    "id": "27010363",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/27010363"
                },
                {
                    "database": "PubMed",
                    "id": "27534430",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/27534430"
                },
                {
                    "database": "PubMed",
                    "id": "28099936",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/28099936"
                },
                {
                    "database": "PubMed",
                    "id": "28981116",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/28981116"
                },
                {
                    "database": "PubMed",
                    "id": "28993609",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/28993609"
                },
                {
                    "database": "PubMed",
                    "id": "29423932",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/29423932"
                },
                {
                    "database": "PubMed",
                    "id": "29533017",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/29533017"
                },
                {
                    "database": "PubMed",
                    "id": "30015961",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/30015961"
                },
                {
                    "database": "PubMed",
                    "id": "30559384",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/30559384"
                },
                {
                    "database": "PubMed",
                    "id": "30690883",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/30690883"
                },
                {
                    "database": "PubMed",
                    "id": "31519735",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/31519735"
                },
                {
                    "database": "PubMed",
                    "id": "31819175",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/31819175"
                },
                {
                    "database": "PubMed",
                    "id": "31844113",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/31844113"
                },
                {
                    "database": "PubMed",
                    "id": "32787969",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/32787969"
                },
                {
                    "database": "PubMed",
                    "id": "35132380",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/35132380"
                },
                {
                    "database": "PubMed",
                    "id": "11237865",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11237865"
                },
                {
                    "database": "PubMed",
                    "id": "31063815",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/31063815"
                }
            ],
            "site_lbl": "Ser256",
            "uniprot_canonical_ac": "Q12778-1"
        }
    ],
    "record_id": "pubmed.10358076",
    "abstract": "",
    "glycosylation": [],
    "mutagenesis": [],
    "snv": [],
    "glycation": [],
    "section_stats": [
        {
            "table_id": "referenced_proteins",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "uniprot_canonical_ac",
                "protein_name",
                "gene_name",
                "tax_name"
            ]
        },
        {
            "table_id": "referenced_glycans",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                },
                {
                    "field": "total_sites",
                    "count": 1
                }
            ],
            "sort_fields": [
                "start_pos",
                "end_pos",
                "kinase_uniprot_canonical_ac",
                "kinase_gene_name",
                "residue",
                "comment",
                "site_lbl",
                "uniprot_canonical_ac"
            ]
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}
