{
    "title": "Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2.",
    "journal": "The Journal of biological chemistry",
    "date": "1999",
    "authors": "Maki CG",
    "reference": {
        "type": "PubMed",
        "id": "10347217",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10347217"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P68431-1",
            "protein_name": "Histone H3.1",
            "gene_name": "H3C10; H3C11; H3C12; H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P06899-1",
            "protein_name": "Histone H2B type 1-J",
            "gene_name": "H2BC11",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P45983-1",
            "protein_name": "Mitogen-activated protein kinase 8",
            "gene_name": "MAPK8",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q16777-1",
            "protein_name": "Histone H2A type 2-C",
            "gene_name": "H2AC20",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q8N4C8-1",
            "protein_name": "Misshapen-like kinase 1",
            "gene_name": "MINK1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q16644-1",
            "protein_name": "MAP kinase-activated protein kinase 3",
            "gene_name": "MAPKAPK3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q14186-1",
            "protein_name": "Transcription factor Dp-1",
            "gene_name": "TFDP1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P42772-1",
            "protein_name": "Cyclin-dependent kinase 4 inhibitor B",
            "gene_name": "CDKN2B",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q16778-1",
            "protein_name": "Histone H2B type 2-E",
            "gene_name": "H2BC21",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q71UI9-1",
            "protein_name": "Histone H2A.V",
            "gene_name": "H2AZ2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q99496-1",
            "protein_name": "E3 ubiquitin-protein ligase RING2",
            "gene_name": "RNF2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q6FI13-1",
            "protein_name": "Histone H2A type 2-A",
            "gene_name": "H2AC18; H2AC19",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q15759-1",
            "protein_name": "Mitogen-activated protein kinase 11",
            "gene_name": "MAPK11",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q00987-1",
            "protein_name": "E3 ubiquitin-protein ligase Mdm2",
            "gene_name": "MDM2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q8IXK0-1",
            "protein_name": "Polyhomeotic-like protein 2",
            "gene_name": "PHC2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P78364-1",
            "protein_name": "Polyhomeotic-like protein 1",
            "gene_name": "PHC1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q99879-1",
            "protein_name": "Histone H2B type 1-M",
            "gene_name": "H2BC14",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q15910-1",
            "protein_name": "Histone-lysine N-methyltransferase EZH2",
            "gene_name": "EZH2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O60814-1",
            "protein_name": "Histone H2B type 1-K",
            "gene_name": "H2BC12",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P62987-1",
            "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein",
            "gene_name": "UBA52",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P0C5Y9-1",
            "protein_name": "Histone H2A-Bbd type 1",
            "gene_name": "H2AB1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q93079-1",
            "protein_name": "Histone H2B type 1-H",
            "gene_name": "H2BC9",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P62805-1",
            "protein_name": "Histone H4",
            "gene_name": "H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O14733-1",
            "protein_name": "Dual specificity mitogen-activated protein kinase kinase 7",
            "gene_name": "MAP2K7",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9HCE1-1",
            "protein_name": "Helicase MOV-10",
            "gene_name": "MOV10",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P0CG48-1",
            "protein_name": "Polyubiquitin-C",
            "gene_name": "UBC",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P46734-1",
            "protein_name": "Dual specificity mitogen-activated protein kinase kinase 3",
            "gene_name": "MAP2K3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P01574-1",
            "protein_name": "Interferon beta",
            "gene_name": "IFNB1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P52564-1",
            "protein_name": "Dual specificity mitogen-activated protein kinase kinase 6",
            "gene_name": "MAP2K6",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9UPQ9-3",
            "protein_name": "Trinucleotide repeat-containing gene 6B protein",
            "gene_name": "TNRC6B",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9H9G7-1",
            "protein_name": "Protein argonaute-3",
            "gene_name": "AGO3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q16539-1",
            "protein_name": "Mitogen-activated protein kinase 14",
            "gene_name": "MAPK14",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P62979-1",
            "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein",
            "gene_name": "RPS27A",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P01100-1",
            "protein_name": "Protein c-Fos",
            "gene_name": "FOS",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q8NDV7-1",
            "protein_name": "Trinucleotide repeat-containing gene 6A protein",
            "gene_name": "TNRC6A",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P62807-1",
            "protein_name": "Histone H2B type 1-C/E/F/G/I",
            "gene_name": "H2BC10; H2BC4; H2BC6; H2BC7; H2BC8",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q96A08-1",
            "protein_name": "Histone H2B type 1-A",
            "gene_name": "H2BC1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P45985-1",
            "protein_name": "Dual specificity mitogen-activated protein kinase kinase 4",
            "gene_name": "MAP2K4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9BTM1-1",
            "protein_name": "Histone H2A.J",
            "gene_name": "H2AJ",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q16576-1",
            "protein_name": "Histone-binding protein RBBP7",
            "gene_name": "RBBP7",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q99683-1",
            "protein_name": "Mitogen-activated protein kinase kinase kinase 5",
            "gene_name": "MAP3K5",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P20671-1",
            "protein_name": "Histone H2A type 1-D",
            "gene_name": "H2AC7",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P10599-1",
            "protein_name": "Thioredoxin",
            "gene_name": "TXN",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q8IW41-1",
            "protein_name": "MAP kinase-activated protein kinase 5",
            "gene_name": "MAPKAPK5",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P0CG47-1",
            "protein_name": "Polyubiquitin-B",
            "gene_name": "UBB",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P04637-1",
            "protein_name": "Cellular tumor antigen p53",
            "gene_name": "TP53",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q8NDX5-1",
            "protein_name": "Polyhomeotic-like protein 3",
            "gene_name": "PHC3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9HC52-1",
            "protein_name": "Chromobox protein homolog 8",
            "gene_name": "CBX8",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P05412-1",
            "protein_name": "Transcription factor Jun",
            "gene_name": "JUN",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q00534-1",
            "protein_name": "Cyclin-dependent kinase 6",
            "gene_name": "CDK6",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O00257-1",
            "protein_name": "E3 SUMO-protein ligase CBX4",
            "gene_name": "CBX4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O95819-1",
            "protein_name": "Mitogen-activated protein kinase kinase kinase kinase 4",
            "gene_name": "MAP4K4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P33778-1",
            "protein_name": "Histone H2B type 1-B",
            "gene_name": "H2BC3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P23527-1",
            "protein_name": "Histone H2B type 1-O",
            "gene_name": "H2BC17",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q71DI3-1",
            "protein_name": "Histone H3.2",
            "gene_name": "H3C13; H3C14; H3C15",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P53779-1",
            "protein_name": "Mitogen-activated protein kinase 10",
            "gene_name": "MAPK10",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P55273-1",
            "protein_name": "Cyclin-dependent kinase 4 inhibitor D",
            "gene_name": "CDKN2D",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P49137-1",
            "protein_name": "MAP kinase-activated protein kinase 2",
            "gene_name": "MAPKAPK2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O15054-2",
            "protein_name": "Lysine-specific demethylase 6B",
            "gene_name": "KDM6B",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P27361-1",
            "protein_name": "Mitogen-activated protein kinase 3",
            "gene_name": "MAPK3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q8N257-1",
            "protein_name": "Histone H2B type 3-B",
            "gene_name": "H2BC26",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P35226-1",
            "protein_name": "Polycomb complex protein BMI-1",
            "gene_name": "BMI1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q93077-1",
            "protein_name": "Histone H2A type 1-C",
            "gene_name": "H2AC6",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P45984-1",
            "protein_name": "Mitogen-activated protein kinase 9",
            "gene_name": "MAPK9",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P42773-1",
            "protein_name": "Cyclin-dependent kinase 4 inhibitor C",
            "gene_name": "CDKN2C",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q01094-1",
            "protein_name": "Transcription factor E2F1",
            "gene_name": "E2F1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q99877-1",
            "protein_name": "Histone H2B type 1-N",
            "gene_name": "H2BC15",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P28482-1",
            "protein_name": "Mitogen-activated protein kinase 1",
            "gene_name": "MAPK1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O00716-1",
            "protein_name": "Transcription factor E2F3",
            "gene_name": "E2F3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q14209-1",
            "protein_name": "Transcription factor E2F2",
            "gene_name": "E2F2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q15022-1",
            "protein_name": "Polycomb protein SUZ12",
            "gene_name": "SUZ12",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9UKE5-1",
            "protein_name": "TRAF2 and NCK-interacting protein kinase",
            "gene_name": "TNIK",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O15151-1",
            "protein_name": "Protein Mdm4",
            "gene_name": "MDM4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9UL18-1",
            "protein_name": "Protein argonaute-1",
            "gene_name": "AGO1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9HCK5-1",
            "protein_name": "Protein argonaute-4",
            "gene_name": "AGO4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P11802-1",
            "protein_name": "Cyclin-dependent kinase 4",
            "gene_name": "CDK4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O75530-1",
            "protein_name": "Polycomb protein EED",
            "gene_name": "EED",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q99880-1",
            "protein_name": "Histone H2B type 1-L",
            "gene_name": "H2BC13",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q14781-1",
            "protein_name": "Chromobox protein homolog 2",
            "gene_name": "CBX2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q14188-1",
            "protein_name": "Transcription factor Dp-2",
            "gene_name": "TFDP2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9HCJ0-3",
            "protein_name": "Trinucleotide repeat-containing gene 6C protein",
            "gene_name": "TNRC6C",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P57053-1",
            "protein_name": "Histone H2B type F-S",
            "gene_name": "H2BC12L",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P58876-1",
            "protein_name": "Histone H2B type 1-D",
            "gene_name": "H2BC5",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P42771-1",
            "protein_name": "Cyclin-dependent kinase inhibitor 2A",
            "gene_name": "CDKN2A",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q99878-1",
            "protein_name": "Histone H2A type 1-J",
            "gene_name": "H2AC14",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O95503-1",
            "protein_name": "Chromobox protein homolog 6",
            "gene_name": "CBX6",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q06587-1",
            "protein_name": "E3 ubiquitin-protein ligase RING1",
            "gene_name": "RING1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q09028-1",
            "protein_name": "Histone-binding protein RBBP4",
            "gene_name": "RBBP4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P16104-1",
            "protein_name": "Histone H2AX",
            "gene_name": "H2AX",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P84243-1",
            "protein_name": "Histone H3.3",
            "gene_name": "H3-3A; H3-3B",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P04908-1",
            "protein_name": "Histone H2A type 1-B/E",
            "gene_name": "H2AC4; H2AC8",
            "tax_name": "Human"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P68431",
                    "url": "https://www.uniprot.org/uniprot/P68431"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "record_id": "pubmed.10347217",
    "abstract": "",
    "glycosylation": [],
    "mutagenesis": [],
    "snv": [],
    "phosphorylation": [],
    "glycation": [],
    "section_stats": [
        {
            "table_id": "referenced_proteins",
            "table_stats": [
                {
                    "field": "total",
                    "count": 91
                }
            ],
            "sort_fields": [
                "uniprot_canonical_ac",
                "protein_name",
                "gene_name",
                "tax_name"
            ]
        },
        {
            "table_id": "referenced_glycans",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}
