{
    "title": "Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation.",
    "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience",
    "date": "1999",
    "authors": "Ando K, Oishi M, Takeda S, Iijima K, Isohara T, Nairn AC, Kirino Y, Greengard P, Suzuki T",
    "reference": {
        "type": "PubMed",
        "id": "10341243",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10341243"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P05067-1",
            "protein_name": "Amyloid-beta precursor protein",
            "gene_name": "APP",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P08592-1",
            "protein_name": "Amyloid-beta precursor protein",
            "gene_name": "App",
            "tax_name": "Rat"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05067",
                    "url": "https://www.uniprot.org/uniprot/P05067"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 743,
            "end_pos": 743,
            "sequence_org": "T",
            "sequence_mut": "A",
            "comment": "Greatly reduces the binding to SHC1 and APBB family members; no effect on NGF-stimulated neurite extension. Loss of phosphorylation by LRRK2.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05067",
                    "url": "https://www.uniprot.org/uniprot/P05067"
                },
                {
                    "database": "PubMed",
                    "id": "11146006",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11146006"
                },
                {
                    "database": "PubMed",
                    "id": "10341243",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10341243"
                },
                {
                    "database": "PubMed",
                    "id": "11877420",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11877420"
                },
                {
                    "database": "PubMed",
                    "id": "11517218",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11517218"
                },
                {
                    "database": "PubMed",
                    "id": "28720718",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/28720718"
                }
            ],
            "uniprot_canonical_ac": "P05067-1"
        },
        {
            "start_pos": 743,
            "end_pos": 743,
            "sequence_org": "T",
            "sequence_mut": "E",
            "comment": "Reduced NGF-stimulated neurite extension. No effect on APP maturation.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05067",
                    "url": "https://www.uniprot.org/uniprot/P05067"
                },
                {
                    "database": "PubMed",
                    "id": "11146006",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11146006"
                },
                {
                    "database": "PubMed",
                    "id": "10341243",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10341243"
                },
                {
                    "database": "PubMed",
                    "id": "11877420",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11877420"
                },
                {
                    "database": "PubMed",
                    "id": "11517218",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11517218"
                }
            ],
            "uniprot_canonical_ac": "P05067-1"
        },
        {
            "start_pos": 743,
            "end_pos": 743,
            "sequence_org": "T",
            "sequence_mut": "A",
            "comment": "No effect on neurite growth and maturation.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P08592",
                    "url": "https://www.uniprot.org/uniprot/P08592"
                },
                {
                    "database": "PubMed",
                    "id": "10341243",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10341243"
                }
            ],
            "uniprot_canonical_ac": "P08592-1"
        },
        {
            "start_pos": 743,
            "end_pos": 743,
            "sequence_org": "T",
            "sequence_mut": "E",
            "comment": "Inhibits neurite growth and maturation.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P08592",
                    "url": "https://www.uniprot.org/uniprot/P08592"
                },
                {
                    "database": "PubMed",
                    "id": "10341243",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10341243"
                }
            ],
            "uniprot_canonical_ac": "P08592-1"
        }
    ],
    "record_id": "pubmed.10341243",
    "abstract": "",
    "glycosylation": [],
    "snv": [],
    "phosphorylation": [],
    "glycation": [],
    "section_stats": [
        {
            "table_id": "referenced_proteins",
            "table_stats": [
                {
                    "field": "total",
                    "count": 2
                }
            ],
            "sort_fields": [
                "uniprot_canonical_ac",
                "protein_name",
                "gene_name",
                "tax_name"
            ]
        },
        {
            "table_id": "referenced_glycans",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}