{
    "title": "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11.",
    "journal": "Proc. Natl. Acad. Sci. U.S.A.",
    "date": "1999",
    "authors": "Snow BE, Betts L, Mangion J, Sondek J, Siderovski DP",
    "reference": {
        "type": "PubMed",
        "id": "10339615",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10339615"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "O14775-1",
            "protein_name": "Guanine nucleotide-binding protein subunit beta-5",
            "gene_name": "GNB5",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P49758-4",
            "protein_name": "Regulator of G-protein signaling 6",
            "gene_name": "RGS6",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O94810-1",
            "protein_name": "Regulator of G-protein signaling 11",
            "gene_name": "RGS11",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P49802-1",
            "protein_name": "Regulator of G-protein signaling 7",
            "gene_name": "RGS7",
            "tax_name": "Human"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
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                    "id": "O14775",
                    "url": "https://www.uniprot.org/uniprot/O14775"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 297,
            "end_pos": 297,
            "sequence_org": "D",
            "sequence_mut": "A",
            "comment": "Loss of interaction with GNB5.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P49758",
                    "url": "https://www.uniprot.org/uniprot/P49758"
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                    "id": "10339615",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10339615"
                }
            ],
            "uniprot_canonical_ac": "P49758-4"
        },
        {
            "start_pos": 309,
            "end_pos": 309,
            "sequence_org": "W",
            "sequence_mut": "F",
            "comment": "Diminishes interaction with GNB5.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P49758",
                    "url": "https://www.uniprot.org/uniprot/P49758"
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                }
            ],
            "uniprot_canonical_ac": "P49758-4"
        },
        {
            "start_pos": 245,
            "end_pos": 245,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "Diminishes interaction with Gbeta5.",
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                    "url": "https://www.uniprot.org/uniprot/O94810"
                },
                {
                    "database": "PubMed",
                    "id": "10339615",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10339615"
                }
            ],
            "uniprot_canonical_ac": "O94810-1"
        },
        {
            "start_pos": 274,
            "end_pos": 274,
            "sequence_org": "W",
            "sequence_mut": "F",
            "comment": "Diminishes interaction with Gbeta5.",
            "evidence": [
                {
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                    "id": "O94810",
                    "url": "https://www.uniprot.org/uniprot/O94810"
                },
                {
                    "database": "PubMed",
                    "id": "10339615",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10339615"
                }
            ],
            "uniprot_canonical_ac": "O94810-1"
        },
        {
            "start_pos": 306,
            "end_pos": 306,
            "sequence_org": "W",
            "sequence_mut": "F",
            "comment": "Diminishes interaction with GNB5.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P49802",
                    "url": "https://www.uniprot.org/uniprot/P49802"
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    "record_id": "pubmed.10339615",
    "abstract": "",
    "glycosylation": [],
    "snv": [],
    "phosphorylation": [],
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