{
    "title": "Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding.",
    "journal": "Protein science : a publication of the Protein Society",
    "date": "1999",
    "authors": "Balendiran GK, Molina JA, Xu Y, Torres-Martinez J, Stevens R, Focia PJ, Eakin AE, Sacchettini JC, Craig SP 3rd",
    "reference": {
        "type": "PubMed",
        "id": "10338013",
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    },
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    "referenced_proteins": [
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            "uniprot_canonical_ac": "P00492-1",
            "protein_name": "Hypoxanthine-guanine phosphoribosyltransferase",
            "gene_name": "HPRT1",
            "tax_name": "Human"
        }
    ],
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        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
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                    "database": "UniProtKB",
                    "id": "P00492",
                    "url": "https://www.uniprot.org/uniprot/P00492"
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            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
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        {
            "start_pos": 69,
            "end_pos": 69,
            "sequence_org": "K",
            "sequence_mut": "A",
            "comment": "Reduced affinity for hypoxanthine, phosphoribosylpyrophosphate and IMP. Reduced catalytic activity.",
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    "record_id": "pubmed.10338013",
    "abstract": "",
    "glycosylation": [],
    "snv": [],
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