{
    "title": "Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB.",
    "journal": "The Journal of biological chemistry",
    "date": "1999",
    "authors": "Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, Carrio R, Merino J, Liu D, Ni J, Nunez G",
    "reference": {
        "type": "PubMed",
        "id": "10329646",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10329646"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "O15264-1",
            "protein_name": "Mitogen-activated protein kinase 13",
            "gene_name": "MAPK13",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O43353-1",
            "protein_name": "Receptor-interacting serine/threonine-protein kinase 2",
            "gene_name": "RIPK2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q96J02-1",
            "protein_name": "E3 ubiquitin-protein ligase Itchy homolog",
            "gene_name": "ITCH",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P42575-1",
            "protein_name": "Caspase-2",
            "gene_name": "CASP2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9Y4K3-1",
            "protein_name": "TNF receptor-associated factor 6",
            "gene_name": "TRAF6",
            "tax_name": "Human"
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        {
            "uniprot_canonical_ac": "Q15759-1",
            "protein_name": "Mitogen-activated protein kinase 11",
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        },
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            "protein_name": "Ubiquitin carboxyl-terminal hydrolase CYLD",
            "gene_name": "CYLD",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P62987-1",
            "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein",
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        },
        {
            "uniprot_canonical_ac": "Q9Y6K9-1",
            "protein_name": "NF-kappa-B essential modulator",
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        },
        {
            "uniprot_canonical_ac": "Q9HC29-1",
            "protein_name": "Nucleotide-binding oligomerization domain-containing protein 2",
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        },
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        },
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            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q8N5C8-1",
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            "gene_name": "TAB3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P52564-1",
            "protein_name": "Dual specificity mitogen-activated protein kinase kinase 6",
            "gene_name": "MAP2K6",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q16539-1",
            "protein_name": "Mitogen-activated protein kinase 14",
            "gene_name": "MAPK14",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P62979-1",
            "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein",
            "gene_name": "RPS27A",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q14790-1",
            "protein_name": "Caspase-8",
            "gene_name": "CASP8",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O43318-1",
            "protein_name": "Mitogen-activated protein kinase kinase kinase 7",
            "gene_name": "MAP3K7",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9H257-1",
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            "tax_name": "Human"
        },
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            "uniprot_canonical_ac": "Q15750-1",
            "protein_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 1",
            "gene_name": "TAB1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P55211-1",
            "protein_name": "Caspase-9",
            "gene_name": "CASP9",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P61088-1",
            "protein_name": "Ubiquitin-conjugating enzyme E2 N",
            "gene_name": "UBE2N",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P49662-1",
            "protein_name": "Caspase-4",
            "gene_name": "CASP4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P0CG47-1",
            "protein_name": "Polyubiquitin-B",
            "gene_name": "UBB",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q13489-1",
            "protein_name": "Baculoviral IAP repeat-containing protein 3",
            "gene_name": "BIRC3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O43187-1",
            "protein_name": "Interleukin-1 receptor-associated kinase-like 2",
            "gene_name": "IRAK2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O14920-1",
            "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta",
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            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q13490-1",
            "protein_name": "Baculoviral IAP repeat-containing protein 2",
            "gene_name": "BIRC2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9Y239-1",
            "protein_name": "Nucleotide-binding oligomerization domain-containing protein 1",
            "gene_name": "NOD1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O15111-1",
            "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha",
            "gene_name": "CHUK",
            "tax_name": "Human"
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        {
            "uniprot_canonical_ac": "P51617-1",
            "protein_name": "Interleukin-1 receptor-associated kinase 1",
            "gene_name": "IRAK1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q13404-4",
            "protein_name": "Ubiquitin-conjugating enzyme E2 variant 1",
            "gene_name": "UBE2V1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P21580-1",
            "protein_name": "Tumor necrosis factor alpha-induced protein 3",
            "gene_name": "TNFAIP3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q13685-1",
            "protein_name": "Angio-associated migratory cell protein",
            "gene_name": "AAMP",
            "tax_name": "Human"
        }
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        {
            "name": "Homo sapiens",
            "taxid": 9606,
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                    "id": "O15264",
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            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
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    ],
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        {
            "start_pos": 208,
            "end_pos": 208,
            "sequence_org": "K",
            "sequence_mut": "R",
            "comment": "Reduces caspase-9 activation. Reduced binding affinity for NLRP10. Does not associate with cell membrane. Reduced NF-kappa-B activation in response to ligand binding.",
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            "comment": "Abolishes interaction with RIPK2/RICK.",
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