{
    "title": "Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers.",
    "journal": "EMBO J.",
    "date": "1999",
    "authors": "Fox AH, Liew C, Holmes M, Kowalski K, Mackay J, Crossley M",
    "reference": {
        "type": "PubMed",
        "id": "10329627",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10329627"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "Q9VPQ6-1",
            "protein_name": "Zinc finger protein ush",
            "gene_name": "ush",
            "tax_name": "Fruit fly"
        },
        {
            "uniprot_canonical_ac": "O35615-1",
            "protein_name": "Zinc finger protein ZFPM1",
            "gene_name": "Zfpm1",
            "tax_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q8CCH7-1",
            "protein_name": "Zinc finger protein ZFPM2",
            "gene_name": "Zfpm2",
            "tax_name": "Mouse"
        }
    ],
    "species": [
        {
            "name": "Drosophila melanogaster",
            "taxid": 7227,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9VPQ6",
                    "url": "https://www.uniprot.org/uniprot/Q9VPQ6"
                }
            ],
            "common_name": "Fruit fly",
            "glygen_name": "Fruit fly",
            "reference_species": "Drosophila melanogaster [7227]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 254,
            "end_pos": 254,
            "sequence_org": "V",
            "sequence_mut": "A",
            "comment": "Does not affect the interaction with GATA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35615",
                    "url": "https://www.uniprot.org/uniprot/O35615"
                },
                {
                    "database": "PubMed",
                    "id": "10329627",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10329627"
                }
            ],
            "uniprot_canonical_ac": "O35615-1"
        },
        {
            "start_pos": 255,
            "end_pos": 255,
            "sequence_org": "F",
            "sequence_mut": "A",
            "comment": "Impairs interaction with GATA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35615",
                    "url": "https://www.uniprot.org/uniprot/O35615"
                },
                {
                    "database": "PubMed",
                    "id": "10329627",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10329627"
                }
            ],
            "uniprot_canonical_ac": "O35615-1"
        },
        {
            "start_pos": 256,
            "end_pos": 256,
            "sequence_org": "P",
            "sequence_mut": "A",
            "comment": "Does not affect the interaction with GATA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35615",
                    "url": "https://www.uniprot.org/uniprot/O35615"
                },
                {
                    "database": "PubMed",
                    "id": "10329627",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10329627"
                }
            ],
            "uniprot_canonical_ac": "O35615-1"
        },
        {
            "start_pos": 258,
            "end_pos": 258,
            "sequence_org": "K",
            "sequence_mut": "A",
            "comment": "Does not affect the interaction with GATA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35615",
                    "url": "https://www.uniprot.org/uniprot/O35615"
                },
                {
                    "database": "PubMed",
                    "id": "10329627",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10329627"
                }
            ],
            "uniprot_canonical_ac": "O35615-1"
        },
        {
            "start_pos": 259,
            "end_pos": 259,
            "sequence_org": "D",
            "sequence_mut": "A",
            "comment": "Does not affect the interaction with GATA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35615",
                    "url": "https://www.uniprot.org/uniprot/O35615"
                },
                {
                    "database": "PubMed",
                    "id": "10329627",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10329627"
                }
            ],
            "uniprot_canonical_ac": "O35615-1"
        },
        {
            "start_pos": 261,
            "end_pos": 261,
            "sequence_org": "G",
            "sequence_mut": "A",
            "comment": "Slightly affects the interaction with GATA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35615",
                    "url": "https://www.uniprot.org/uniprot/O35615"
                },
                {
                    "database": "PubMed",
                    "id": "10329627",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10329627"
                }
            ],
            "uniprot_canonical_ac": "O35615-1"
        },
        {
            "start_pos": 262,
            "end_pos": 262,
            "sequence_org": "I",
            "sequence_mut": "A",
            "comment": "Impairs interaction with GATA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35615",
                    "url": "https://www.uniprot.org/uniprot/O35615"
                },
                {
                    "database": "PubMed",
                    "id": "10329627",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10329627"
                }
            ],
            "uniprot_canonical_ac": "O35615-1"
        },
        {
            "start_pos": 263,
            "end_pos": 263,
            "sequence_org": "W",
            "sequence_mut": "A",
            "comment": "Does not affect the interaction with GATA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35615",
                    "url": "https://www.uniprot.org/uniprot/O35615"
                },
                {
                    "database": "PubMed",
                    "id": "10329627",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10329627"
                }
            ],
            "uniprot_canonical_ac": "O35615-1"
        },
        {
            "start_pos": 265,
            "end_pos": 265,
            "sequence_org": "R",
            "sequence_mut": "A",
            "comment": "Slightly affects the interaction with GATA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35615",
                    "url": "https://www.uniprot.org/uniprot/O35615"
                },
                {
                    "database": "PubMed",
                    "id": "10329627",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10329627"
                }
            ],
            "uniprot_canonical_ac": "O35615-1"
        },
        {
            "start_pos": 266,
            "end_pos": 266,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "Does not affect the interaction with GATA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35615",
                    "url": "https://www.uniprot.org/uniprot/O35615"
                },
                {
                    "database": "PubMed",
                    "id": "10329627",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10329627"
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            ],
            "uniprot_canonical_ac": "O35615-1"
        },
        {
            "start_pos": 267,
            "end_pos": 267,
            "sequence_org": "E",
            "sequence_mut": "A",
            "comment": "Slightly affects the interaction with GATA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35615",
                    "url": "https://www.uniprot.org/uniprot/O35615"
                },
                {
                    "database": "PubMed",
                    "id": "10329627",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10329627"
                }
            ],
            "uniprot_canonical_ac": "O35615-1"
        },
        {
            "start_pos": 268,
            "end_pos": 268,
            "sequence_org": "R",
            "sequence_mut": "A",
            "comment": "Does not affect the interaction with GATA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35615",
                    "url": "https://www.uniprot.org/uniprot/O35615"
                },
                {
                    "database": "PubMed",
                    "id": "10329627",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10329627"
                }
            ],
            "uniprot_canonical_ac": "O35615-1"
        },
        {
            "start_pos": 269,
            "end_pos": 269,
            "sequence_org": "N",
            "sequence_mut": "A",
            "comment": "Impairs interaction with GATA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35615",
                    "url": "https://www.uniprot.org/uniprot/O35615"
                },
                {
                    "database": "PubMed",
                    "id": "10329627",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10329627"
                }
            ],
            "uniprot_canonical_ac": "O35615-1"
        },
        {
            "start_pos": 271,
            "end_pos": 271,
            "sequence_org": "Q",
            "sequence_mut": "A",
            "comment": "Does not affect the interaction with GATA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35615",
                    "url": "https://www.uniprot.org/uniprot/O35615"
                },
                {
                    "database": "PubMed",
                    "id": "10329627",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10329627"
                }
            ],
            "uniprot_canonical_ac": "O35615-1"
        },
        {
            "start_pos": 274,
            "end_pos": 274,
            "sequence_org": "L",
            "sequence_mut": "A",
            "comment": "Slightly affects the interaction with GATA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35615",
                    "url": "https://www.uniprot.org/uniprot/O35615"
                },
                {
                    "database": "PubMed",
                    "id": "10329627",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10329627"
                }
            ],
            "uniprot_canonical_ac": "O35615-1"
        },
        {
            "start_pos": 275,
            "end_pos": 275,
            "sequence_org": "L",
            "sequence_mut": "A",
            "comment": "Does not affect the interaction with GATA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35615",
                    "url": "https://www.uniprot.org/uniprot/O35615"
                },
                {
                    "database": "PubMed",
                    "id": "10329627",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10329627"
                }
            ],
            "uniprot_canonical_ac": "O35615-1"
        },
        {
            "start_pos": 276,
            "end_pos": 276,
            "sequence_org": "Y",
            "sequence_mut": "A",
            "comment": "Slightly affects the interaction with GATA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35615",
                    "url": "https://www.uniprot.org/uniprot/O35615"
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                {
                    "database": "PubMed",
                    "id": "10329627",
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            ],
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        },
        {
            "start_pos": 277,
            "end_pos": 277,
            "sequence_org": "Y",
            "sequence_mut": "A",
            "comment": "Impairs interaction with GATA1. Strongly impairs interaction with GATA1; when associated with A-612; A-718 and/or A-985.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35615",
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                {
                    "database": "PubMed",
                    "id": "10329627",
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            ],
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        },
        {
            "start_pos": 280,
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            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "Does not affect the interaction with GATA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35615",
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                {
                    "database": "PubMed",
                    "id": "10329627",
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            ],
            "uniprot_canonical_ac": "O35615-1"
        },
        {
            "start_pos": 281,
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            "sequence_org": "R",
            "sequence_mut": "A",
            "comment": "Does not affect the interaction with GATA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O35615",
                    "url": "https://www.uniprot.org/uniprot/O35615"
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                {
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        {
            "start_pos": 612,
            "end_pos": 612,
            "sequence_org": "Y",
            "sequence_mut": "A",
            "comment": "Impairs interaction with GATA1. Strongly impairs interaction with GATA1; when associated with A-277; A-718 and/or A-985.",
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                {
                    "database": "UniProtKB",
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                {
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        {
            "start_pos": 718,
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            "sequence_org": "Y",
            "sequence_mut": "A",
            "comment": "Impairs interaction with GATA1. Strongly impairs interaction with GATA1; when associated with A-277; A-612 and/or A-985.",
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                {
                    "database": "UniProtKB",
                    "id": "O35615",
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                {
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        {
            "start_pos": 811,
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            "sequence_org": "PIDL",
            "sequence_mut": "AIAA",
            "comment": "Abolishes interaction with CTBP2.",
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                {
                    "database": "UniProtKB",
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        {
            "start_pos": 985,
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            "sequence_org": "Y",
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            "comment": "Slightly affects the interaction with GATA1. Strongly impairs interaction with GATA1; when associated with A-277; A-612 and/or A-718.",
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    "abstract": "",
    "glycosylation": [],
    "snv": [],
    "phosphorylation": [],
    "glycation": [],
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