{
    "title": "Enhancement of insulin-like growth factor signaling in human breast cancer: estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo.",
    "journal": "Molecular endocrinology (Baltimore, Md.)",
    "date": "1999",
    "authors": "Lee AV, Jackson JG, Gooch JL, Hilsenbeck SG, Coronado-Heinsohn E, Osborne CK, Yee D",
    "reference": {
        "type": "PubMed",
        "id": "10319328",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10319328"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "Q9NXF8-1",
            "protein_name": "Palmitoyltransferase ZDHHC7",
            "gene_name": "ZDHHC7",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P29474-1",
            "protein_name": "Nitric oxide synthase 3",
            "gene_name": "NOS3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P04899-1",
            "protein_name": "Guanine nucleotide-binding protein G(i) subunit alpha-2",
            "gene_name": "GNAI2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9P2W3-1",
            "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13",
            "gene_name": "GNG13",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P35070-1",
            "protein_name": "Probetacellulin",
            "gene_name": "BTC",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O00459-1",
            "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit beta",
            "gene_name": "PIK3R2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O14944-1",
            "protein_name": "Proepiregulin",
            "gene_name": "EREG",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P62879-1",
            "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2",
            "gene_name": "GNB2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P01133-1",
            "protein_name": "Pro-epidermal growth factor",
            "gene_name": "EGF",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O14610-1",
            "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2",
            "gene_name": "GNGT2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O14775-1",
            "protein_name": "Guanine nucleotide-binding protein subunit beta-5",
            "gene_name": "GNB5",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P08253-1",
            "protein_name": "72 kDa type IV collagenase",
            "gene_name": "MMP2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9UBI6-1",
            "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12",
            "gene_name": "GNG12",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P15514-1",
            "protein_name": "Amphiregulin",
            "gene_name": "AREG",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P03372-1",
            "protein_name": "Estrogen receptor",
            "gene_name": "ESR1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P01135-1",
            "protein_name": "Protransforming growth factor alpha",
            "gene_name": "TGFA",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P27986-1",
            "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit alpha",
            "gene_name": "PIK3R1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P50150-1",
            "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4",
            "gene_name": "GNG4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P08754-1",
            "protein_name": "Guanine nucleotide-binding protein G(i) subunit alpha-3",
            "gene_name": "GNAI3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O60262-1",
            "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7",
            "gene_name": "GNG7",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P04792-1",
            "protein_name": "Heat shock protein beta-1",
            "gene_name": "HSPB1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P07900-1",
            "protein_name": "Heat shock protein HSP 90-alpha",
            "gene_name": "HSP90AA1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P59768-1",
            "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2",
            "gene_name": "GNG2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q99500-1",
            "protein_name": "Sphingosine 1-phosphate receptor 3",
            "gene_name": "S1PR3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9UK08-1",
            "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8",
            "gene_name": "GNG8",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q99873-1",
            "protein_name": "Protein arginine N-methyltransferase 1",
            "gene_name": "PRMT1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P62873-1",
            "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1",
            "gene_name": "GNB1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P42336-1",
            "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform",
            "gene_name": "PIK3CA",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9HAV0-1",
            "protein_name": "Guanine nucleotide-binding protein subunit beta-4",
            "gene_name": "GNB4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q03135-1",
            "protein_name": "Caveolin-1",
            "gene_name": "CAV1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P16520-1",
            "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3",
            "gene_name": "GNB3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P63218-1",
            "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5",
            "gene_name": "GNG5",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q92569-1",
            "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit gamma",
            "gene_name": "PIK3R3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P50151-1",
            "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10",
            "gene_name": "GNG10",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q6UW88-1",
            "protein_name": "Epigen",
            "gene_name": "EPGN",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P63215-1",
            "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3",
            "gene_name": "GNG3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O43815-1",
            "protein_name": "Striatin",
            "gene_name": "STRN",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9NYA1-1",
            "protein_name": "Sphingosine kinase 1",
            "gene_name": "SPHK1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "A8MTJ3-1",
            "protein_name": "Guanine nucleotide-binding protein G(t) subunit alpha-3",
            "gene_name": "GNAT3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P0DP23-1",
            "protein_name": "Calmodulin-1",
            "gene_name": "CALM1; CALM2; CALM3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P09237-1",
            "protein_name": "Matrilysin",
            "gene_name": "MMP7",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q99075-1",
            "protein_name": "Proheparin-binding EGF-like growth factor",
            "gene_name": "HBEGF",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P12931-1",
            "protein_name": "Proto-oncogene tyrosine-protein kinase Src",
            "gene_name": "SRC",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P61952-1",
            "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11",
            "gene_name": "GNG11",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q8IVQ6-1",
            "protein_name": "Palmitoyltransferase ZDHHC21",
            "gene_name": "ZDHHC21",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P14780-1",
            "protein_name": "Matrix metalloproteinase-9",
            "gene_name": "MMP9",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P63211-1",
            "protein_name": "Guanine nucleotide-binding protein G(T) subunit gamma-T1",
            "gene_name": "GNGT1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P00533-1",
            "protein_name": "Epidermal growth factor receptor",
            "gene_name": "EGFR",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q05397-1",
            "protein_name": "Focal adhesion kinase 1",
            "gene_name": "PTK2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P63096-1",
            "protein_name": "Guanine nucleotide-binding protein G(i) subunit alpha-1",
            "gene_name": "GNAI1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P51636-1",
            "protein_name": "Caveolin-2",
            "gene_name": "CAV2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q92731-1",
            "protein_name": "Estrogen receptor beta",
            "gene_name": "ESR2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P31749-1",
            "protein_name": "RAC-alpha serine/threonine-protein kinase",
            "gene_name": "AKT1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P08254-1",
            "protein_name": "Stromelysin-1",
            "gene_name": "MMP3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P08069-1",
            "protein_name": "Insulin-like growth factor 1 receptor",
            "gene_name": "IGF1R",
            "tax_name": "Human"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9NXF8",
                    "url": "https://www.uniprot.org/uniprot/Q9NXF8"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "record_id": "pubmed.10319328",
    "abstract": "",
    "glycosylation": [],
    "mutagenesis": [],
    "snv": [],
    "phosphorylation": [],
    "glycation": [],
    "section_stats": [
        {
            "table_id": "referenced_proteins",
            "table_stats": [
                {
                    "field": "total",
                    "count": 55
                }
            ],
            "sort_fields": [
                "uniprot_canonical_ac",
                "protein_name",
                "gene_name",
                "tax_name"
            ]
        },
        {
            "table_id": "referenced_glycans",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}
