{
    "title": "Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodelling.",
    "journal": "The Biochemical journal",
    "date": "1999",
    "authors": "Ashworth JL, Murphy G, Rock MJ, Sherratt MJ, Shapiro SD, Shuttleworth CA, Kielty CM",
    "reference": {
        "type": "PubMed",
        "id": "10229672",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10229672"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P01023-1",
            "protein_name": "Alpha-2-macroglobulin",
            "gene_name": "A2M",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q16787-2",
            "protein_name": "Laminin subunit alpha-3",
            "gene_name": "LAMA3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9P2N4-3",
            "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 9",
            "gene_name": "ADAMTS9",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q8IX30-1",
            "protein_name": "Signal peptide, CUB and EGF-like domain-containing protein 3",
            "gene_name": "SCUBE3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q92542-1",
            "protein_name": "Nicastrin",
            "gene_name": "NCSTN",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q6MZZ7-1",
            "protein_name": "Calpain-13",
            "gene_name": "CAPN13",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P24347-1",
            "protein_name": "Stromelysin-3",
            "gene_name": "MMP11",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P45452-1",
            "protein_name": "Collagenase 3",
            "gene_name": "MMP13",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P07585-1",
            "protein_name": "Decorin",
            "gene_name": "DCN",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P49862-1",
            "protein_name": "Kallikrein-7",
            "gene_name": "KLK7",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O15230-1",
            "protein_name": "Laminin subunit alpha-5",
            "gene_name": "LAMA5",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P43235-1",
            "protein_name": "Cathepsin K",
            "gene_name": "CTSK",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9UHI8-1",
            "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 1",
            "gene_name": "ADAMTS1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O60882-1",
            "protein_name": "Matrix metalloproteinase-20",
            "gene_name": "MMP20",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P35556-1",
            "protein_name": "Fibrillin-2",
            "gene_name": "FBN2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P08311-1",
            "protein_name": "Cathepsin G",
            "gene_name": "CTSG",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P20810-1",
            "protein_name": "Calpastatin",
            "gene_name": "CAST",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q96L46-1",
            "protein_name": "Calpain small subunit 2",
            "gene_name": "CAPNS2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P50281-1",
            "protein_name": "Matrix metalloproteinase-14",
            "gene_name": "MMP14",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P12830-1",
            "protein_name": "Cadherin-1",
            "gene_name": "CDH1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9UMQ6-1",
            "protein_name": "Calpain-11",
            "gene_name": "CAPN11",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O75808-1",
            "protein_name": "Calpain-15",
            "gene_name": "CAPN15",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P16070-1",
            "protein_name": "CD44 antigen",
            "gene_name": "CD44",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P08253-1",
            "protein_name": "72 kDa type IV collagenase",
            "gene_name": "MMP2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P03956-1",
            "protein_name": "Interstitial collagenase",
            "gene_name": "MMP1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P35613-1",
            "protein_name": "Basigin",
            "gene_name": "BSG",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q99542-1",
            "protein_name": "Matrix metalloproteinase-19",
            "gene_name": "MMP19",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P07942-1",
            "protein_name": "Laminin subunit beta-1",
            "gene_name": "LAMB1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q8TE60-1",
            "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 18",
            "gene_name": "ADAMTS18",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P22894-1",
            "protein_name": "Neutrophil collagenase",
            "gene_name": "MMP8",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9Y6Q1-1",
            "protein_name": "Calpain-6",
            "gene_name": "CAPN6",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P17655-1",
            "protein_name": "Calpain-2 catalytic subunit",
            "gene_name": "CAPN2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9Y6L7-1",
            "protein_name": "Tolloid-like protein 2",
            "gene_name": "TLL2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9UBM4-1",
            "protein_name": "Opticin",
            "gene_name": "OPTC",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P11047-1",
            "protein_name": "Laminin subunit gamma-1",
            "gene_name": "LAMC1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q92743-1",
            "protein_name": "Serine protease HTRA1",
            "gene_name": "HTRA1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q8IU80-4",
            "protein_name": "Transmembrane protease serine 6",
            "gene_name": "TMPRSS6",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9UP79-1",
            "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 8",
            "gene_name": "ADAMTS8",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P51511-1",
            "protein_name": "Matrix metalloproteinase-15",
            "gene_name": "MMP15",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q8TE57-1",
            "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 16",
            "gene_name": "ADAMTS16",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q13751-1",
            "protein_name": "Laminin subunit beta-3",
            "gene_name": "LAMB3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q13444-1",
            "protein_name": "Disintegrin and metalloproteinase domain-containing protein 15",
            "gene_name": "ADAM15",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P14543-1",
            "protein_name": "Nidogen-1",
            "gene_name": "NID1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P02751-15",
            "protein_name": "Fibronectin",
            "gene_name": "FN1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9Y6W3-1",
            "protein_name": "Calpain-7",
            "gene_name": "CAPN7",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P49768-1",
            "protein_name": "Presenilin-1",
            "gene_name": "PSEN1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P25774-1",
            "protein_name": "Cathepsin S",
            "gene_name": "CTSS",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P15502-3",
            "protein_name": "Elastin",
            "gene_name": "ELN",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O43897-1",
            "protein_name": "Tolloid-like protein 1",
            "gene_name": "TLL1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P07711-1",
            "protein_name": "Procathepsin L",
            "gene_name": "CTSL",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q6ZSI9-1",
            "protein_name": "Calpain-12",
            "gene_name": "CAPN12",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "A8MX76-1",
            "protein_name": "Calpain-14",
            "gene_name": "CAPN14",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q8IWY4-1",
            "protein_name": "Signal peptide, CUB and EGF-like domain-containing protein 1",
            "gene_name": "SCUBE1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P39900-1",
            "protein_name": "Macrophage metalloelastase",
            "gene_name": "MMP12",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q13753-1",
            "protein_name": "Laminin subunit gamma-2",
            "gene_name": "LAMC2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P00747-1",
            "protein_name": "Plasminogen",
            "gene_name": "PLG",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P10451-1",
            "protein_name": "Osteopontin",
            "gene_name": "SPP1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O15484-1",
            "protein_name": "Calpain-5",
            "gene_name": "CAPN5",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q96GW7-1",
            "protein_name": "Brevican core protein",
            "gene_name": "BCAN",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P08246-1",
            "protein_name": "Neutrophil elastase",
            "gene_name": "ELANE",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P98160-1",
            "protein_name": "Basement membrane-specific heparan sulfate proteoglycan core protein",
            "gene_name": "HSPG2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P07384-1",
            "protein_name": "Calpain-1 catalytic subunit",
            "gene_name": "CAPN1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P09237-1",
            "protein_name": "Matrilysin",
            "gene_name": "MMP7",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P13497-1",
            "protein_name": "Bone morphogenetic protein 1",
            "gene_name": "BMP1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9HC96-1",
            "protein_name": "Calpain-10",
            "gene_name": "CAPN10",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P35555-1",
            "protein_name": "Fibrillin-1",
            "gene_name": "FBN1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P42574-1",
            "protein_name": "Caspase-3",
            "gene_name": "CASP3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9UNA0-1",
            "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 5",
            "gene_name": "ADAMTS5",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P14780-1",
            "protein_name": "Matrix metalloproteinase-9",
            "gene_name": "MMP9",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O14672-1",
            "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10",
            "gene_name": "ADAM10",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P04632-1",
            "protein_name": "Calpain small subunit 1",
            "gene_name": "CAPNS1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P78325-1",
            "protein_name": "Disintegrin and metalloproteinase domain-containing protein 8",
            "gene_name": "ADAM8",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P09238-1",
            "protein_name": "Stromelysin-2",
            "gene_name": "MMP10",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P20807-1",
            "protein_name": "Calpain-3",
            "gene_name": "CAPN3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q75N90-1",
            "protein_name": "Fibrillin-3",
            "gene_name": "FBN3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O14815-1",
            "protein_name": "Calpain-9",
            "gene_name": "CAPN9",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P16112-1",
            "protein_name": "Aggrecan core protein",
            "gene_name": "ACAN",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O60911-1",
            "protein_name": "Cathepsin L2",
            "gene_name": "CTSV",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "A6NHC0-1",
            "protein_name": "Calpain-8",
            "gene_name": "CAPN8",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O75173-1",
            "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 4",
            "gene_name": "ADAMTS4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P08254-1",
            "protein_name": "Stromelysin-1",
            "gene_name": "MMP3",
            "tax_name": "Human"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01023",
                    "url": "https://www.uniprot.org/uniprot/P01023"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "record_id": "pubmed.10229672",
    "abstract": "",
    "glycosylation": [],
    "mutagenesis": [],
    "snv": [],
    "phosphorylation": [],
    "glycation": [],
    "section_stats": [
        {
            "table_id": "referenced_proteins",
            "table_stats": [
                {
                    "field": "total",
                    "count": 81
                }
            ],
            "sort_fields": [
                "uniprot_canonical_ac",
                "protein_name",
                "gene_name",
                "tax_name"
            ]
        },
        {
            "table_id": "referenced_glycans",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}
