{
    "title": "A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta.",
    "journal": "The Journal of biological chemistry",
    "date": "1999",
    "authors": "Maeda N, Ichihara-Tanaka K, Kimura T, Kadomatsu K, Muramatsu T, Noda M",
    "reference": {
        "type": "PubMed",
        "id": "10212223",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10212223"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "Q9UM73-1",
            "protein_name": "ALK tyrosine kinase receptor",
            "gene_name": "ALK",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q62656-1",
            "protein_name": "Receptor-type tyrosine-protein phosphatase zeta",
            "gene_name": "Ptprz1",
            "tax_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "P21741-1",
            "protein_name": "Midkine",
            "gene_name": "MDK",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P12025-1",
            "protein_name": "Midkine",
            "gene_name": "Mdk",
            "tax_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "P21246-1",
            "protein_name": "Pleiotrophin",
            "gene_name": "PTN",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P23471-1",
            "protein_name": "Receptor-type tyrosine-protein phosphatase zeta",
            "gene_name": "PTPRZ1",
            "tax_name": "Human"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9UM73",
                    "url": "https://www.uniprot.org/uniprot/Q9UM73"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 100,
            "end_pos": 100,
            "sequence_org": "R",
            "sequence_mut": "Q",
            "comment": "Decreases affinity binding to PTPRZ1. Decreases affinity binding to PTPRZ1; when associated with Q-105 and Q-106. Decreases neuron migration. Decreases neuron migration; when associated with Q-105 and Q-106.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P12025",
                    "url": "https://www.uniprot.org/uniprot/P12025"
                },
                {
                    "database": "PubMed",
                    "id": "10212223",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10212223"
                }
            ],
            "uniprot_canonical_ac": "P12025-1"
        },
        {
            "start_pos": 105,
            "end_pos": 105,
            "sequence_org": "K",
            "sequence_mut": "Q",
            "comment": "Does not affect binding with PTPRZ1. Does not affect binding with PTPRZ1; when associated with Q-106. Does not affect positive regulation of neuron migration.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P12025",
                    "url": "https://www.uniprot.org/uniprot/P12025"
                },
                {
                    "database": "PubMed",
                    "id": "10212223",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10212223"
                }
            ],
            "uniprot_canonical_ac": "P12025-1"
        },
        {
            "start_pos": 106,
            "end_pos": 106,
            "sequence_org": "K",
            "sequence_mut": "Q",
            "comment": "Does not affect binding with PTPRZ1. Does not affect binding with PTPRZ1; when associated with Q-105. Does not affect positive regulation of neuron migration.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P12025",
                    "url": "https://www.uniprot.org/uniprot/P12025"
                },
                {
                    "database": "PubMed",
                    "id": "10212223",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10212223"
                }
            ],
            "uniprot_canonical_ac": "P12025-1"
        }
    ],
    "record_id": "pubmed.10212223",
    "abstract": "",
    "glycosylation": [],
    "snv": [],
    "phosphorylation": [],
    "glycation": [],
    "section_stats": [
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