{
    "title": "SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T-cell activation.",
    "journal": "J. Exp. Med.",
    "date": "1999",
    "authors": "Marie-Cardine A, Kirchgessner H, Bruyns E, Shevchenko A, Mann M, Autschbach F, Ratnofsky S, Meuer S, Schraven B",
    "reference": {
        "type": "PubMed",
        "id": "10209036",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10209036"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "Q06124-2",
            "protein_name": "Tyrosine-protein phosphatase non-receptor type 11",
            "gene_name": "PTPN11",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9Y3P8-1",
            "protein_name": "Signaling threshold-regulating transmembrane adapter 1",
            "gene_name": "SIT1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q8C503-1",
            "protein_name": "Signaling threshold-regulating transmembrane adapter 1",
            "gene_name": "Sit1",
            "tax_name": "Mouse"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q06124",
                    "url": "https://www.uniprot.org/uniprot/Q06124"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "glycosylation": [
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "other",
            "prediction_tool": "",
            "mining_tool": "",
            "site_category": "predicted",
            "site_category_dict": {
                "predicted": true
            },
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 26,
            "start_aa": "Asn",
            "end_pos": 26,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn26",
            "evidence": [
                {
                    "id": "Q9Y3P8",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/Q9Y3P8#ptm_processing"
                },
                {
                    "id": "10209036",
                    "database": "PubMed",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10209036"
                }
            ],
            "filter_code": "00100000000000000000.00010000000000.0.01100",
            "uniprot_canonical_ac": "Q9Y3P8-1"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 148,
            "end_pos": 148,
            "sequence_org": "Y",
            "sequence_mut": "F",
            "comment": "Reduces interaction with PTPN11, no effect on inhibition of NF-AT activation.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Y3P8",
                    "url": "https://www.uniprot.org/uniprot/Q9Y3P8"
                },
                {
                    "database": "PubMed",
                    "id": "10209036",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10209036"
                },
                {
                    "database": "PubMed",
                    "id": "11433379",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11433379"
                }
            ],
            "uniprot_canonical_ac": "Q9Y3P8-1"
        },
        {
            "start_pos": 26,
            "end_pos": 26,
            "sequence_org": "N",
            "sequence_mut": "Q",
            "comment": "Abolishes glycosylation.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Y3P8",
                    "url": "https://www.uniprot.org/uniprot/Q9Y3P8"
                },
                {
                    "database": "PubMed",
                    "id": "10209036",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10209036"
                }
            ],
            "uniprot_canonical_ac": "Q9Y3P8-1"
        }
    ],
    "phosphorylation": [
        {
            "start_pos": 127,
            "end_pos": 127,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Tyr",
            "comment": "Phosphotyrosine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Y3P8",
                    "url": "https://www.uniprot.org/uniprot/Q9Y3P8"
                },
                {
                    "database": "PubMed",
                    "id": "11433379",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11433379"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q9Y3P8",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9Y3P8"
                },
                {
                    "database": "PubMed",
                    "id": "10209036",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10209036"
                },
                {
                    "database": "phospho.ELM",
                    "id": "Q9Y3P8",
                    "url": "http://phospho.elm.eu.org/byAccession/Q9Y3P8.html"
                }
            ],
            "site_lbl": "Tyr127",
            "uniprot_canonical_ac": "Q9Y3P8-1"
        },
        {
            "start_pos": 148,
            "end_pos": 148,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Tyr",
            "comment": "Phosphotyrosine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Y3P8",
                    "url": "https://www.uniprot.org/uniprot/Q9Y3P8"
                },
                {
                    "database": "PubMed",
                    "id": "11433379",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11433379"
                },
                {
                    "database": "PubMed",
                    "id": "10209036",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10209036"
                },
                {
                    "database": "PubMed",
                    "id": "19690332",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/19690332"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q9Y3P8",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9Y3P8"
                },
                {
                    "database": "PubMed",
                    "id": "15144186",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/15144186"
                },
                {
                    "database": "IntAct",
                    "id": "Q9Y3P8",
                    "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9Y3P8*"
                },
                {
                    "database": "phospho.ELM",
                    "id": "Q9Y3P8",
                    "url": "http://phospho.elm.eu.org/byAccession/Q9Y3P8.html"
                },
                {
                    "database": "PubMed",
                    "id": "15659558",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/15659558"
                },
                {
                    "database": "PubMed",
                    "id": "16094384",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/16094384"
                }
            ],
            "site_lbl": "Tyr148",
            "uniprot_canonical_ac": "Q9Y3P8-1"
        },
        {
            "start_pos": 169,
            "end_pos": 169,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Tyr",
            "comment": "Phosphotyrosine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Y3P8",
                    "url": "https://www.uniprot.org/uniprot/Q9Y3P8"
                },
                {
                    "database": "PubMed",
                    "id": "11433379",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11433379"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q9Y3P8",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9Y3P8"
                },
                {
                    "database": "PubMed",
                    "id": "10209036",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10209036"
                },
                {
                    "database": "phospho.ELM",
                    "id": "Q9Y3P8",
                    "url": "http://phospho.elm.eu.org/byAccession/Q9Y3P8.html"
                }
            ],
            "site_lbl": "Tyr169",
            "uniprot_canonical_ac": "Q9Y3P8-1"
        },
        {
            "start_pos": 188,
            "end_pos": 188,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Tyr",
            "comment": "Phosphotyrosine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9Y3P8",
                    "url": "https://www.uniprot.org/uniprot/Q9Y3P8"
                },
                {
                    "database": "PubMed",
                    "id": "15144186",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/15144186"
                },
                {
                    "database": "PubMed",
                    "id": "19690332",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/19690332"
                },
                {
                    "database": "PubMed",
                    "id": "11433379",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11433379"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q9Y3P8",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9Y3P8"
                },
                {
                    "database": "PubMed",
                    "id": "10209036",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10209036"
                },
                {
                    "database": "phospho.ELM",
                    "id": "Q9Y3P8",
                    "url": "http://phospho.elm.eu.org/byAccession/Q9Y3P8.html"
                },
                {
                    "database": "PubMed",
                    "id": "15592455",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/15592455"
                }
            ],
            "site_lbl": "Tyr188",
            "uniprot_canonical_ac": "Q9Y3P8-1"
        }
    ],
    "record_id": "pubmed.10209036",
    "abstract": "",
    "snv": [],
    "glycation": [],
    "section_stats": [
        {
            "table_id": "referenced_proteins",
            "table_stats": [
                {
                    "field": "total",
                    "count": 3
                }
            ],
            "sort_fields": [
                "uniprot_canonical_ac",
                "protein_name",
                "gene_name",
                "tax_name"
            ]
        },
        {
            "table_id": "referenced_glycans",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                },
                {
                    "field": "total_sites",
                    "count": 1
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 1
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": [
                "glytoucan_ac",
                "type",
                "subtype",
                "prediction_tool",
                "mining_tool",
                "site_category",
                "site_seq",
                "relation",
                "comment",
                "start_pos",
                "start_aa",
                "end_pos",
                "end_aa",
                "residue",
                "site_lbl",
                "filter_code",
                "uniprot_canonical_ac"
            ]
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 4
                },
                {
                    "field": "total_sites",
                    "count": 4
                }
            ],
            "sort_fields": [
                "start_pos",
                "end_pos",
                "kinase_uniprot_canonical_ac",
                "kinase_gene_name",
                "residue",
                "comment",
                "site_lbl",
                "uniprot_canonical_ac"
            ]
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                },
                {
                    "field": "total_sites",
                    "count": 1
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 1
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": [
                "glytoucan_ac",
                "type",
                "subtype",
                "prediction_tool",
                "mining_tool",
                "site_category",
                "site_seq",
                "relation",
                "comment",
                "start_pos",
                "start_aa",
                "end_pos",
                "end_aa",
                "residue",
                "site_lbl",
                "filter_code",
                "uniprot_canonical_ac"
            ]
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}
