{
    "title": "Molecular determinants of the estrogen receptor-coactivator interface.",
    "journal": "Molecular and cellular biology",
    "date": "1999",
    "authors": "Mak HY, Hoare S, Henttu PM, Parker MG",
    "reference": {
        "type": "PubMed",
        "id": "10207113",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10207113"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P19785-1",
            "protein_name": "Estrogen receptor",
            "gene_name": "Esr1",
            "tax_name": "Mouse"
        }
    ],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P19785",
                    "url": "https://www.uniprot.org/uniprot/P19785"
                }
            ],
            "common_name": "Mouse",
            "glygen_name": "Mouse",
            "reference_species": "Mus musculus [10090]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 362,
            "end_pos": 362,
            "sequence_org": "I",
            "sequence_mut": "A",
            "comment": "No effect on transcriptional activity and estrogen-induced interaction with NCOA1. Abolishes estrogen-induced interaction with NCOA1; when associated with A-376 and A-380.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P19785",
                    "url": "https://www.uniprot.org/uniprot/P19785"
                },
                {
                    "database": "PubMed",
                    "id": "10207113",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10207113"
                }
            ],
            "uniprot_canonical_ac": "P19785-1"
        },
        {
            "start_pos": 362,
            "end_pos": 362,
            "sequence_org": "I",
            "sequence_mut": "D",
            "comment": "Abolishes transcriptional activity and estrogen-induced interaction with NCOA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P19785",
                    "url": "https://www.uniprot.org/uniprot/P19785"
                },
                {
                    "database": "PubMed",
                    "id": "10207113",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10207113"
                }
            ],
            "uniprot_canonical_ac": "P19785-1"
        },
        {
            "start_pos": 366,
            "end_pos": 366,
            "sequence_org": "K",
            "sequence_mut": "A",
            "comment": "Greatly reduces transcriptional activity and estrogen-induced interaction with NCOA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P19785",
                    "url": "https://www.uniprot.org/uniprot/P19785"
                },
                {
                    "database": "PubMed",
                    "id": "10207113",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10207113"
                }
            ],
            "uniprot_canonical_ac": "P19785-1"
        },
        {
            "start_pos": 366,
            "end_pos": 366,
            "sequence_org": "K",
            "sequence_mut": "D",
            "comment": "Abolishes transcriptional activity and estrogen-induced interaction with NCOA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P19785",
                    "url": "https://www.uniprot.org/uniprot/P19785"
                },
                {
                    "database": "PubMed",
                    "id": "10207113",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10207113"
                }
            ],
            "uniprot_canonical_ac": "P19785-1"
        },
        {
            "start_pos": 366,
            "end_pos": 366,
            "sequence_org": "K",
            "sequence_mut": "L",
            "comment": "Reduces transcriptional activity and estrogen-induced interaction with NCOA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P19785",
                    "url": "https://www.uniprot.org/uniprot/P19785"
                },
                {
                    "database": "PubMed",
                    "id": "10207113",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10207113"
                }
            ],
            "uniprot_canonical_ac": "P19785-1"
        },
        {
            "start_pos": 376,
            "end_pos": 376,
            "sequence_org": "L",
            "sequence_mut": "A",
            "comment": "Reduces transcriptional activity, no effect on estrogen-induced interaction with NCOA1. Abolishes estrogen-induced interaction with NCOA1; when associated with A-362 and A-380.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P19785",
                    "url": "https://www.uniprot.org/uniprot/P19785"
                },
                {
                    "database": "PubMed",
                    "id": "10207113",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10207113"
                }
            ],
            "uniprot_canonical_ac": "P19785-1"
        },
        {
            "start_pos": 376,
            "end_pos": 376,
            "sequence_org": "L",
            "sequence_mut": "D",
            "comment": "Reduces transcriptional activity and estrogen-induced interaction with NCOA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P19785",
                    "url": "https://www.uniprot.org/uniprot/P19785"
                },
                {
                    "database": "PubMed",
                    "id": "10207113",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10207113"
                }
            ],
            "uniprot_canonical_ac": "P19785-1"
        },
        {
            "start_pos": 380,
            "end_pos": 380,
            "sequence_org": "V",
            "sequence_mut": "A",
            "comment": "No effect on transcriptional activity and estrogen-induced interaction with NCOA1. Abolishes estrogen-induced interaction with NCOA1; when associated with A-362 and A-376.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P19785",
                    "url": "https://www.uniprot.org/uniprot/P19785"
                },
                {
                    "database": "PubMed",
                    "id": "10207113",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10207113"
                }
            ],
            "uniprot_canonical_ac": "P19785-1"
        },
        {
            "start_pos": 380,
            "end_pos": 380,
            "sequence_org": "V",
            "sequence_mut": "D",
            "comment": "Abolishes transcriptional activity and estrogen-induced interaction with NCOA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P19785",
                    "url": "https://www.uniprot.org/uniprot/P19785"
                },
                {
                    "database": "PubMed",
                    "id": "10207113",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10207113"
                }
            ],
            "uniprot_canonical_ac": "P19785-1"
        },
        {
            "start_pos": 543,
            "end_pos": 543,
            "sequence_org": "L",
            "sequence_mut": "A",
            "comment": "Abolishes estrogen-induced interaction with NCOA1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P19785",
                    "url": "https://www.uniprot.org/uniprot/P19785"
                },
                {
                    "database": "PubMed",
                    "id": "10207113",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10207113"
                }
            ],
            "uniprot_canonical_ac": "P19785-1"
        }
    ],
    "record_id": "pubmed.10207113",
    "abstract": "",
    "glycosylation": [],
    "snv": [],
    "phosphorylation": [],
    "glycation": [],
    "section_stats": [
        {
            "table_id": "referenced_proteins",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                }
            ],
            "sort_fields": [
                "uniprot_canonical_ac",
                "protein_name",
                "gene_name",
                "tax_name"
            ]
        },
        {
            "table_id": "referenced_glycans",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}