{
    "title": "A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.",
    "journal": "Nature",
    "date": "1999",
    "authors": "De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R",
    "reference": {
        "type": "PubMed",
        "id": "10206645",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10206645"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "Q8IZL2-1",
            "protein_name": "Mastermind-like protein 2",
            "gene_name": "MAML2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q92769-1",
            "protein_name": "Histone deacetylase 2",
            "gene_name": "HDAC2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9Y2E6-1",
            "protein_name": "E3 ubiquitin-protein ligase DTX4",
            "gene_name": "DTX4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q96J02-1",
            "protein_name": "E3 ubiquitin-protein ligase Itchy homolog",
            "gene_name": "ITCH",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P78536-1",
            "protein_name": "Disintegrin and metalloproteinase domain-containing protein 17",
            "gene_name": "ADAM17",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9Y618-1",
            "protein_name": "Nuclear receptor corepressor 2",
            "gene_name": "NCOR2",
            "tax_name": "Human"
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            "uniprot_canonical_ac": "Q92542-1",
            "protein_name": "Nicastrin",
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            "tax_name": "Human"
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        {
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            "protein_name": "Protein jagged-2",
            "gene_name": "JAG2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P49757-1",
            "protein_name": "Protein numb homolog",
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        },
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            "uniprot_canonical_ac": "Q92793-1",
            "protein_name": "CREB-binding protein",
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        },
        {
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            "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 1",
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        },
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        },
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            "uniprot_canonical_ac": "Q92830-1",
            "protein_name": "Histone acetyltransferase KAT2A",
            "gene_name": "KAT2A",
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        {
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        },
        {
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            "protein_name": "Histone deacetylase 6",
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            "tax_name": "Human"
        },
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            "uniprot_canonical_ac": "Q13495-1",
            "protein_name": "Mastermind-like domain-containing protein 1",
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        },
        {
            "uniprot_canonical_ac": "O15379-1",
            "protein_name": "Histone deacetylase 3",
            "gene_name": "HDAC3",
            "tax_name": "Human"
        },
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            "gene_name": "UBA52",
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        },
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        },
        {
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            "gene_name": "UBC",
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        },
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            "uniprot_canonical_ac": "A8MQ27-1",
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            "gene_name": "NEURL1B",
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            "uniprot_canonical_ac": "Q13616-1",
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            "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein",
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            "uniprot_canonical_ac": "Q06330-1",
            "protein_name": "Recombining binding protein suppressor of hairless",
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            "protein_name": "Midkine",
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        {
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        },
        {
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        },
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    "species": [
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            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
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                    "database": "UniProtKB",
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            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
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    "record_id": "pubmed.10206645",
    "abstract": "",
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