{
    "title": "Conserved amino acids in the ligand-binding and tau(i) domains of the peroxisome proliferator-activated receptor alpha are necessary for heterodimerization with RXR.",
    "journal": "Molecular and cellular endocrinology",
    "date": "1999",
    "authors": "Gorla-Bajszczak A, Juge-Aubry C, Pernin A, Burger AG, Meier CA",
    "reference": {
        "type": "PubMed",
        "id": "10195690",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10195690"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P19793-1",
            "protein_name": "Retinoic acid receptor RXR-alpha",
            "gene_name": "RXRA",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q07869-1",
            "protein_name": "Peroxisome proliferator-activated receptor alpha",
            "gene_name": "PPARA",
            "tax_name": "Human"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P19793",
                    "url": "https://www.uniprot.org/uniprot/P19793"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 304,
            "end_pos": 304,
            "sequence_org": "D",
            "sequence_mut": "A",
            "comment": "Reduced heterodimerization with RXRA. Reduced DNA binding.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q07869",
                    "url": "https://www.uniprot.org/uniprot/Q07869"
                },
                {
                    "database": "PubMed",
                    "id": "10195690",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10195690"
                }
            ],
            "uniprot_canonical_ac": "Q07869-1"
        },
        {
            "start_pos": 370,
            "end_pos": 370,
            "sequence_org": "L",
            "sequence_mut": "R",
            "comment": "Abolishes heterodimerization with RXRA. No DNA binding.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q07869",
                    "url": "https://www.uniprot.org/uniprot/Q07869"
                },
                {
                    "database": "PubMed",
                    "id": "10195690",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10195690"
                }
            ],
            "uniprot_canonical_ac": "Q07869-1"
        },
        {
            "start_pos": 391,
            "end_pos": 391,
            "sequence_org": "L",
            "sequence_mut": "R",
            "comment": "Abolishes heterodimerization with RXRA. No DNA binding.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q07869",
                    "url": "https://www.uniprot.org/uniprot/Q07869"
                },
                {
                    "database": "PubMed",
                    "id": "10195690",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10195690"
                }
            ],
            "uniprot_canonical_ac": "Q07869-1"
        },
        {
            "start_pos": 431,
            "end_pos": 431,
            "sequence_org": "A",
            "sequence_mut": "T",
            "comment": "No effect on heterodimerization with RXRA nor on DNA binding.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q07869",
                    "url": "https://www.uniprot.org/uniprot/Q07869"
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                    "database": "PubMed",
                    "id": "10195690",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10195690"
                }
            ],
            "uniprot_canonical_ac": "Q07869-1"
        }
    ],
    "record_id": "pubmed.10195690",
    "abstract": "",
    "glycosylation": [],
    "snv": [],
    "phosphorylation": [],
    "glycation": [],
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