{
    "title": "Analysis of mutations in the yeast mRNA decapping enzyme.",
    "journal": "Genetics",
    "date": "1999-04",
    "authors": "Tharun S, Parker R",
    "reference": {
        "type": "PubMed",
        "id": "10101156",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10101156"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "Q12517-1",
            "protein_name": "mRNA-decapping enzyme subunit 1",
            "gene_name": "DCP1",
            "tax_name": "Baker's yeast"
        }
    ],
    "species": [
        {
            "name": "Saccharomyces cerevisiae S288C",
            "taxid": 559292,
            "evidence": [
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                    "database": "UniProtKB",
                    "id": "Q12517",
                    "url": "https://www.uniprot.org/uniprot/Q12517"
                }
            ],
            "common_name": "Baker's yeast",
            "glygen_name": "Yeast",
            "reference_species": "Saccharomyces cerevisiae S288C [559292]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 156,
            "end_pos": 156,
            "sequence_org": "G",
            "sequence_mut": "D",
            "comment": "In DCP1-1; strong loss of mRNA decapping activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12517",
                    "url": "https://www.uniprot.org/uniprot/Q12517"
                },
                {
                    "database": "PubMed",
                    "id": "10101156",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10101156"
                }
            ],
            "uniprot_canonical_ac": "Q12517-1"
        },
        {
            "start_pos": 16,
            "end_pos": 20,
            "sequence_org": "EFYRK",
            "sequence_mut": "AFYAA",
            "comment": "In DCP1-17; partial loss of mRNA-decapping activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12517",
                    "url": "https://www.uniprot.org/uniprot/Q12517"
                },
                {
                    "database": "PubMed",
                    "id": "10101156",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10101156"
                }
            ],
            "uniprot_canonical_ac": "Q12517-1"
        },
        {
            "start_pos": 187,
            "end_pos": 188,
            "sequence_org": "KD",
            "sequence_mut": "AA",
            "comment": "In DCP1-19; partial loss of mRNA decapping activity. In DCP1-43; strong loss of mRNA-decapping activity; when associated with A-48 and A-50.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12517",
                    "url": "https://www.uniprot.org/uniprot/Q12517"
                },
                {
                    "database": "PubMed",
                    "id": "10101156",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10101156"
                }
            ],
            "uniprot_canonical_ac": "Q12517-1"
        },
        {
            "start_pos": 204,
            "end_pos": 204,
            "sequence_org": "W",
            "sequence_mut": "A",
            "comment": "In DCP1-33; partial loss of mRNA decapping activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12517",
                    "url": "https://www.uniprot.org/uniprot/Q12517"
                },
                {
                    "database": "PubMed",
                    "id": "10101156",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10101156"
                }
            ],
            "uniprot_canonical_ac": "Q12517-1"
        },
        {
            "start_pos": 216,
            "end_pos": 219,
            "sequence_org": "ELIK",
            "sequence_mut": "ALIA",
            "comment": "In DCP1-25; partial loss of mRNA-decapping activity. In DCP1-44; strong loss of mRNA-decapping activity; when associated with A-48 and A-50.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12517",
                    "url": "https://www.uniprot.org/uniprot/Q12517"
                },
                {
                    "database": "PubMed",
                    "id": "10101156",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10101156"
                }
            ],
            "uniprot_canonical_ac": "Q12517-1"
        },
        {
            "start_pos": 29,
            "end_pos": 31,
            "sequence_org": "RYD",
            "sequence_mut": "AYA",
            "comment": "In DCP1-2; strong loss of mRNA decapping activity at 36 degrees Celsius.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12517",
                    "url": "https://www.uniprot.org/uniprot/Q12517"
                },
                {
                    "database": "PubMed",
                    "id": "14758354",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/14758354"
                },
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                    "database": "PubMed",
                    "id": "10101156",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10101156"
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            ],
            "uniprot_canonical_ac": "Q12517-1"
        },
        {
            "start_pos": 47,
            "end_pos": 47,
            "sequence_org": "Y",
            "sequence_mut": "A",
            "comment": "In DCP1-32; partial loss of mRNA decapping activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12517",
                    "url": "https://www.uniprot.org/uniprot/Q12517"
                },
                {
                    "database": "PubMed",
                    "id": "10101156",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10101156"
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            "uniprot_canonical_ac": "Q12517-1"
        },
        {
            "start_pos": 47,
            "end_pos": 47,
            "sequence_org": "Y",
            "sequence_mut": "F",
            "comment": "In DCP1-35; partial loss of mRNA decapping activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q12517",
                    "url": "https://www.uniprot.org/uniprot/Q12517"
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        },
        {
            "start_pos": 48,
            "end_pos": 50,
            "sequence_org": "KWD",
            "sequence_mut": "AWA",
            "comment": "In DCP1-4; partial loss of mRNA decapping activity. In DCP1-43; strong loss of mRNA-decapping activity; when associated with A-187 and A-188. In DCP1-44; strong loss of mRNA-decapping activity; when associated with A-216 and A-219.",
            "evidence": [
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            "start_pos": 56,
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            "sequence_org": "W",
            "sequence_mut": "A",
            "comment": "In DCP1-31; partial loss of mRNA decapping activity.",
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            "start_pos": 70,
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            "sequence_org": "R",
            "sequence_mut": "A",
            "comment": "In DCP1-33; strong loss of mRNA decapping activity.",
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                    "database": "UniProtKB",
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    "abstract": "",
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