{
    "title": "Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein.",
    "journal": "Proceedings of the National Academy of Sciences of the United States of America",
    "date": "1999",
    "authors": "Hsieh JC, Rattner A, Smallwood PM, Nathans J",
    "reference": {
        "type": "PubMed",
        "id": "10097073",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10097073"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "Q9NPG1-1",
            "protein_name": "Frizzled-3",
            "gene_name": "FZD3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9ULV1-1",
            "protein_name": "Frizzled-4",
            "gene_name": "FZD4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q96A98-1",
            "protein_name": "Tuberoinfundibular peptide of 39 residues",
            "gene_name": "PTH2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P24387-1",
            "protein_name": "Corticotropin-releasing factor-binding protein",
            "gene_name": "CRHBP",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P41221-1",
            "protein_name": "Protein Wnt-5a",
            "gene_name": "WNT5A",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P56704-1",
            "protein_name": "Protein Wnt-3a",
            "gene_name": "WNT3A",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O14904-1",
            "protein_name": "Protein Wnt-9a",
            "gene_name": "WNT9A",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9VVX3-1",
            "protein_name": "Frizzled-2",
            "gene_name": "fz2",
            "tax_name": "Fruit fly"
        },
        {
            "uniprot_canonical_ac": "P55089-1",
            "protein_name": "Urocortin",
            "gene_name": "UCN",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9GZT5-1",
            "protein_name": "Protein Wnt-10a",
            "gene_name": "WNT10A",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P56706-1",
            "protein_name": "Protein Wnt-7b",
            "gene_name": "WNT7B",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9H1J5-1",
            "protein_name": "Protein Wnt-8a",
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        },
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            "uniprot_canonical_ac": "P04628-1",
            "protein_name": "Proto-oncogene Wnt-1",
            "gene_name": "WNT1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O00755-1",
            "protein_name": "Protein Wnt-7a",
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            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P01270-1",
            "protein_name": "Parathyroid hormone",
            "gene_name": "PTH",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9UHX3-1",
            "protein_name": "Adhesion G protein-coupled receptor E2",
            "gene_name": "ADGRE2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q969E3-1",
            "protein_name": "Urocortin-3",
            "gene_name": "UCN3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P06850-1",
            "protein_name": "Corticoliberin",
            "gene_name": "CRH",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q03431-1",
            "protein_name": "Parathyroid hormone/parathyroid hormone-related peptide receptor",
            "gene_name": "PTH1R",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q93098-1",
            "protein_name": "Protein Wnt-8b",
            "gene_name": "WNT8B",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O60353-1",
            "protein_name": "Frizzled-6",
            "gene_name": "FZD6",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q61090-1",
            "protein_name": "Frizzled-7",
            "gene_name": "Fzd7",
            "tax_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q14332-1",
            "protein_name": "Frizzled-2",
            "gene_name": "FZD2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P48960-1",
            "protein_name": "Adhesion G protein-coupled receptor E5",
            "gene_name": "ADGRE5",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q13635-1",
            "protein_name": "Protein patched homolog 1",
            "gene_name": "PTCH1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9Y6F9-1",
            "protein_name": "Protein Wnt-6",
            "gene_name": "WNT6",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q14623-1",
            "protein_name": "Indian hedgehog protein",
            "gene_name": "IHH",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q61089-1",
            "protein_name": "Frizzled-6",
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            "tax_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q93097-1",
            "protein_name": "Protein Wnt-2b",
            "gene_name": "WNT2B",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q96RP3-1",
            "protein_name": "Urocortin-2",
            "gene_name": "UCN2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O00744-1",
            "protein_name": "Protein Wnt-10b",
            "gene_name": "WNT10B",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q61091-1",
            "protein_name": "Frizzled-8",
            "gene_name": "Fzd8",
            "tax_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q9ULW2-1",
            "protein_name": "Frizzled-10",
            "gene_name": "FZD10",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P34998-2",
            "protein_name": "Corticotropin-releasing factor receptor 1",
            "gene_name": "CRHR1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q15465-1",
            "protein_name": "Sonic hedgehog protein",
            "gene_name": "SHH",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9UP38-1",
            "protein_name": "Frizzled-1",
            "gene_name": "FZD1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P56703-1",
            "protein_name": "Proto-oncogene Wnt-3",
            "gene_name": "WNT3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O96014-1",
            "protein_name": "Protein Wnt-11",
            "gene_name": "WNT11",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O43323-1",
            "protein_name": "Desert hedgehog protein",
            "gene_name": "DHH",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q61088-1",
            "protein_name": "Frizzled-4",
            "gene_name": "Fzd4",
            "tax_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q13467-1",
            "protein_name": "Frizzled-5",
            "gene_name": "FZD5",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O75084-1",
            "protein_name": "Frizzled-7",
            "gene_name": "FZD7",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P09544-1",
            "protein_name": "Protein Wnt-2",
            "gene_name": "WNT2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9BY15-1",
            "protein_name": "Adhesion G protein-coupled receptor E3",
            "gene_name": "ADGRE3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P08174-1",
            "protein_name": "Complement decay-accelerating factor",
            "gene_name": "CD55",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O14905-1",
            "protein_name": "Protein Wnt-9b",
            "gene_name": "WNT9B",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P56705-1",
            "protein_name": "Protein Wnt-4",
            "gene_name": "WNT4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9UBV4-1",
            "protein_name": "Protein Wnt-16",
            "gene_name": "WNT16",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9H461-1",
            "protein_name": "Frizzled-8",
            "gene_name": "FZD8",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P49190-1",
            "protein_name": "Parathyroid hormone 2 receptor",
            "gene_name": "PTH2R",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q99835-1",
            "protein_name": "Protein smoothened",
            "gene_name": "SMO",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q14246-1",
            "protein_name": "Adhesion G protein-coupled receptor E1",
            "gene_name": "ADGRE1",
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        },
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            "uniprot_canonical_ac": "Q9Y6C5-1",
            "protein_name": "Protein patched homolog 2",
            "gene_name": "PTCH2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P12272-1",
            "protein_name": "Parathyroid hormone-related protein",
            "gene_name": "PTHLH",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O00144-1",
            "protein_name": "Frizzled-9",
            "gene_name": "FZD9",
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            "name": "Homo sapiens",
            "taxid": 9606,
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                    "database": "UniProtKB",
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            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
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    "record_id": "pubmed.10097073",
    "abstract": "",
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