{
    "title": "Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry.",
    "journal": "Cell",
    "date": "1999",
    "authors": "Farzan M, Mirzabekov T, Kolchinsky P, Wyatt R, Cayabyab M, Gerard NP, Gerard C, Sodroski J, Choe H",
    "reference": {
        "type": "PubMed",
        "id": "10089882",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10089882"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P61073-1",
            "protein_name": "C-X-C chemokine receptor type 4",
            "gene_name": "CXCR4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P51681-1",
            "protein_name": "C-C chemokine receptor type 5",
            "gene_name": "CCR5",
            "tax_name": "Human"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P61073",
                    "url": "https://www.uniprot.org/uniprot/P61073"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 10,
            "end_pos": 10,
            "sequence_org": "Y",
            "sequence_mut": "F",
            "comment": "No sulfation and greatly decreases binding of CCL4 and CCL5; when associated with F-3; F-14 and F-15. Small loss of sulfation; when associated with F-14 and F-15.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P51681",
                    "url": "https://www.uniprot.org/uniprot/P51681"
                },
                {
                    "database": "PubMed",
                    "id": "11733580",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11733580"
                },
                {
                    "database": "PubMed",
                    "id": "10089882",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10089882"
                }
            ],
            "uniprot_canonical_ac": "P51681-1"
        },
        {
            "start_pos": 14,
            "end_pos": 14,
            "sequence_org": "Y",
            "sequence_mut": "D",
            "comment": "No sulfation and greatly decreased binding of CCL4 and CCL5; when associated with D-3; D-10 and D-14. No restoration of CCL4 binding; when associated with D-10 and D-15.",
            "evidence": [
                {
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                    "id": "P51681",
                    "url": "https://www.uniprot.org/uniprot/P51681"
                },
                {
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                },
                {
                    "database": "PubMed",
                    "id": "10089882",
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            ],
            "uniprot_canonical_ac": "P51681-1"
        },
        {
            "start_pos": 14,
            "end_pos": 14,
            "sequence_org": "Y",
            "sequence_mut": "F",
            "comment": "No sulfation and greatly decreases binding of CCL4 and CCL5; when associated with F-3; F-10; and F-15. Small loss of sulfation; when associated with F-10 and F-15.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P51681",
                    "url": "https://www.uniprot.org/uniprot/P51681"
                },
                {
                    "database": "PubMed",
                    "id": "11733580",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11733580"
                },
                {
                    "database": "PubMed",
                    "id": "10089882",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10089882"
                }
            ],
            "uniprot_canonical_ac": "P51681-1"
        },
        {
            "start_pos": 15,
            "end_pos": 15,
            "sequence_org": "Y",
            "sequence_mut": "D",
            "comment": "No sulfation and greatly decreased binding of CCL4 and CCL5; when associated with D-3; D-10 and D-14. Restored most CCL4 binding; when associated with D-3 and D-10.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P51681",
                    "url": "https://www.uniprot.org/uniprot/P51681"
                },
                {
                    "database": "PubMed",
                    "id": "11733580",
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        },
        {
            "start_pos": 15,
            "end_pos": 15,
            "sequence_org": "Y",
            "sequence_mut": "F",
            "comment": "No sulfation and greatly decreases binding of CCL4 and CCL5; when associated with F-3; F-10 and F-14. Small loss of sulfation; when associated with F-10 and F-14.",
            "evidence": [
                {
                    "database": "UniProtKB",
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            "start_pos": 3,
            "end_pos": 3,
            "sequence_org": "Y",
            "sequence_mut": "D",
            "comment": "No sulfation and strongly decreases binding with CCL4 and CCL5; when associated with D-10; D-14 and D-15. Restores most CCL4 binding; when associated with D-10 and D-15.",
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            "start_pos": 3,
            "end_pos": 3,
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            "sequence_mut": "F",
            "comment": "No sulfation and strongly decreases binding with CCL4 and CCL5; when associated with F-10; F-14 and F-15.",
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    "abstract": "",
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