{
    "title": "Turn scanning by site-directed mutagenesis: application to the protein folding problem using the intestinal fatty acid binding protein.",
    "journal": "Protein science : a publication of the Protein Society",
    "date": "1998",
    "authors": "Kim K, Frieden C",
    "reference": {
        "type": "PubMed",
        "id": "10082380",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10082380"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P02693-1",
            "protein_name": "Fatty acid-binding protein, intestinal",
            "gene_name": "Fabp2",
            "tax_name": "Rat"
        }
    ],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
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                    "database": "UniProtKB",
                    "id": "P02693",
                    "url": "https://www.uniprot.org/uniprot/P02693"
                }
            ],
            "common_name": "Rat",
            "glygen_name": "Rat",
            "reference_species": "Rattus norvegicus [10116]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 100,
            "end_pos": 100,
            "sequence_org": "G",
            "sequence_mut": "V",
            "comment": "Large reduction in stability.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P02693",
                    "url": "https://www.uniprot.org/uniprot/P02693"
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            ],
            "uniprot_canonical_ac": "P02693-1"
        },
        {
            "start_pos": 111,
            "end_pos": 111,
            "sequence_org": "G",
            "sequence_mut": "V",
            "comment": "Small reduction in stability, impaired ligand binding.",
            "evidence": [
                {
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                    "id": "P02693",
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            "uniprot_canonical_ac": "P02693-1"
        },
        {
            "start_pos": 122,
            "end_pos": 122,
            "sequence_org": "G",
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            "comment": "Large reduction in stability.",
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            ],
            "uniprot_canonical_ac": "P02693-1"
        },
        {
            "start_pos": 45,
            "end_pos": 45,
            "sequence_org": "G",
            "sequence_mut": "V",
            "comment": "Small reduction in stability, impaired ligand binding.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P02693",
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            ],
            "uniprot_canonical_ac": "P02693-1"
        },
        {
            "start_pos": 55,
            "end_pos": 55,
            "sequence_org": "N",
            "sequence_mut": "V",
            "comment": "No reduction in stability.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P02693",
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            ],
            "uniprot_canonical_ac": "P02693-1"
        },
        {
            "start_pos": 66,
            "end_pos": 66,
            "sequence_org": "G",
            "sequence_mut": "V",
            "comment": "Large reduction in stability.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P02693",
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            "comment": "Reduced stability.",
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            "start_pos": 81,
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            "comment": "Large reduction in stability.",
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            "start_pos": 87,
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            "comment": "No reduction in stability, impaired ligand binding.",
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    "abstract": "",
    "glycosylation": [],
    "snv": [],
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