{
    "title": "The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop.",
    "journal": "The EMBO journal",
    "date": "1999",
    "authors": "Yasukawa H, Misawa H, Sakamoto H, Masuhara M, Sasaki A, Wakioka T, Ohtsuka S, Imaizumi T, Matsuda T, Ihle JN, Yoshimura A",
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        "id": "10064597",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10064597"
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        {
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            "protein_name": "Suppressor of cytokine signaling 1",
            "gene_name": "SOCS1",
            "tax_name": "Human"
        },
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            "uniprot_canonical_ac": "P38484-1",
            "protein_name": "Interferon gamma receptor 2",
            "gene_name": "IFNGR2",
            "tax_name": "Human"
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            "tax_name": "Human"
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            "uniprot_canonical_ac": "O35716-1",
            "protein_name": "Suppressor of cytokine signaling 1",
            "gene_name": "Socs1",
            "tax_name": "Mouse"
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        {
            "uniprot_canonical_ac": "P01579-1",
            "protein_name": "Interferon gamma",
            "gene_name": "IFNG",
            "tax_name": "Human"
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        {
            "uniprot_canonical_ac": "O14543-1",
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            "tax_name": "Human"
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            "uniprot_canonical_ac": "P15260-1",
            "protein_name": "Interferon gamma receptor 1",
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            "tax_name": "Human"
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        {
            "uniprot_canonical_ac": "P29350-1",
            "protein_name": "Tyrosine-protein phosphatase non-receptor type 6",
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            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q06124-2",
            "protein_name": "Tyrosine-protein phosphatase non-receptor type 11",
            "gene_name": "PTPN11",
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        {
            "uniprot_canonical_ac": "O60674-1",
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            "uniprot_canonical_ac": "Q62120-1",
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        },
        {
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            "gene_name": "PIAS1",
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        },
        {
            "uniprot_canonical_ac": "P18031-1",
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            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P63165-1",
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        {
            "name": "Homo sapiens",
            "taxid": 9606,
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            "glygen_name": "Human",
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        {
            "start_pos": 105,
            "end_pos": 105,
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            "sequence_mut": "K",
            "comment": "Loss of LIF signal transduction suppression. Loss of binding to KIT. No effect on binding to VAV.",
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        {
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        {
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        {
            "start_pos": 56,
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            "comment": "No effect on JAK signal transduction inhibition nor on binding to JH1.",
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                    "database": "UniProtKB",
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        {
            "start_pos": 56,
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                    "database": "PubMed",
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        {
            "start_pos": 57,
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            "sequence_mut": "A",
            "comment": "No effect on JAK signal transduction suppression.",
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                {
                    "database": "UniProtKB",
                    "id": "O35716",
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        {
            "start_pos": 57,
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            "comment": "No effect on JAK signal transduction suppression.",
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                    "database": "PubMed",
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            "comment": "No effect on LIF signal transduction suppression.",
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        {
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            "comment": "No effect on JAK signal transduction suppression.",
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