{
    "title": "p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2.",
    "journal": "Science (New York, N.Y.)",
    "date": "1999",
    "authors": "Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T",
    "reference": {
        "type": "PubMed",
        "id": "10037601",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10037601"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P06899-1",
            "protein_name": "Histone H2B type 1-J",
            "gene_name": "H2BC11",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q16777-1",
            "protein_name": "Histone H2A type 2-C",
            "gene_name": "H2AC20",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q13315-1",
            "protein_name": "Serine-protein kinase ATM",
            "gene_name": "ATM",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q96AP0-3",
            "protein_name": "Adrenocortical dysplasia protein homolog",
            "gene_name": "ACD",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q16778-1",
            "protein_name": "Histone H2B type 2-E",
            "gene_name": "H2BC21",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q71UI9-1",
            "protein_name": "Histone H2A.V",
            "gene_name": "H2AZ2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P54274-1",
            "protein_name": "Telomeric repeat-binding factor 1",
            "gene_name": "TERF1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q6FI13-1",
            "protein_name": "Histone H2A type 2-A",
            "gene_name": "H2AC18; H2AC19",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q99879-1",
            "protein_name": "Histone H2B type 1-M",
            "gene_name": "H2BC14",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O60814-1",
            "protein_name": "Histone H2B type 1-K",
            "gene_name": "H2BC12",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P0C5Y9-1",
            "protein_name": "Histone H2A-Bbd type 1",
            "gene_name": "H2AB1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q92993-1",
            "protein_name": "Histone acetyltransferase KAT5",
            "gene_name": "KAT5",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q93079-1",
            "protein_name": "Histone H2B type 1-H",
            "gene_name": "H2BC9",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q15554-3",
            "protein_name": "Telomeric repeat-binding factor 2",
            "gene_name": "TERF2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O96020-1",
            "protein_name": "G1/S-specific cyclin-E2",
            "gene_name": "CCNE2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P62805-1",
            "protein_name": "Histone H4",
            "gene_name": "H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P20248-1",
            "protein_name": "Cyclin-A2",
            "gene_name": "CCNA2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P38936-1",
            "protein_name": "Cyclin-dependent kinase inhibitor 1",
            "gene_name": "CDKN1A",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P46527-1",
            "protein_name": "Cyclin-dependent kinase inhibitor 1B",
            "gene_name": "CDKN1B",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P62807-1",
            "protein_name": "Histone H2B type 1-C/E/F/G/I",
            "gene_name": "H2BC10; H2BC4; H2BC6; H2BC7; H2BC8",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q96A08-1",
            "protein_name": "Histone H2B type 1-A",
            "gene_name": "H2BC1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9NUX5-1",
            "protein_name": "Protection of telomeres protein 1",
            "gene_name": "POT1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9BTM1-1",
            "protein_name": "Histone H2A.J",
            "gene_name": "H2AJ",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P20671-1",
            "protein_name": "Histone H2A type 1-D",
            "gene_name": "H2AC7",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P04637-1",
            "protein_name": "Cellular tumor antigen p53",
            "gene_name": "TP53",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P33778-1",
            "protein_name": "Histone H2B type 1-B",
            "gene_name": "H2BC3",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P23527-1",
            "protein_name": "Histone H2B type 1-O",
            "gene_name": "H2BC17",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "O60934-1",
            "protein_name": "Nibrin",
            "gene_name": "NBN",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q8N257-1",
            "protein_name": "Histone H2B type 3-B",
            "gene_name": "H2BC26",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q93077-1",
            "protein_name": "Histone H2A type 1-C",
            "gene_name": "H2AC6",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P49959-1",
            "protein_name": "Double-strand break repair protein MRE11",
            "gene_name": "MRE11",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q16695-1",
            "protein_name": "Histone H3.1t",
            "gene_name": "H3-4",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P78396-1",
            "protein_name": "Cyclin-A1",
            "gene_name": "CCNA1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q92878-1",
            "protein_name": "DNA repair protein RAD50",
            "gene_name": "RAD50",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q99877-1",
            "protein_name": "Histone H2B type 1-N",
            "gene_name": "H2BC15",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9NYB0-1",
            "protein_name": "Telomeric repeat-binding factor 2-interacting protein 1",
            "gene_name": "TERF2IP",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9BSI4-1",
            "protein_name": "TERF1-interacting nuclear factor 2",
            "gene_name": "TINF2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q99880-1",
            "protein_name": "Histone H2B type 1-L",
            "gene_name": "H2BC13",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P57053-1",
            "protein_name": "Histone H2B type F-S",
            "gene_name": "H2BC12L",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P58876-1",
            "protein_name": "Histone H2B type 1-D",
            "gene_name": "H2BC5",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q99878-1",
            "protein_name": "Histone H2A type 1-J",
            "gene_name": "H2AC14",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q96L91-1",
            "protein_name": "E1A-binding protein p400",
            "gene_name": "EP400",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P24941-1",
            "protein_name": "Cyclin-dependent kinase 2",
            "gene_name": "CDK2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P16104-1",
            "protein_name": "Histone H2AX",
            "gene_name": "H2AX",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P24864-1",
            "protein_name": "G1/S-specific cyclin-E1",
            "gene_name": "CCNE1",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P04908-1",
            "protein_name": "Histone H2A type 1-B/E",
            "gene_name": "H2AC4; H2AC8",
            "tax_name": "Human"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P06899",
                    "url": "https://www.uniprot.org/uniprot/P06899"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "record_id": "pubmed.10037601",
    "abstract": "",
    "glycosylation": [],
    "mutagenesis": [],
    "snv": [],
    "phosphorylation": [],
    "glycation": [],
    "section_stats": [
        {
            "table_id": "referenced_proteins",
            "table_stats": [
                {
                    "field": "total",
                    "count": 46
                }
            ],
            "sort_fields": [
                "uniprot_canonical_ac",
                "protein_name",
                "gene_name",
                "tax_name"
            ]
        },
        {
            "table_id": "referenced_glycans",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}