{
    "title": "Identification of three distinct receptor binding sites of murine interleukin-11.",
    "journal": "The Journal of biological chemistry",
    "date": "1999",
    "authors": "Barton VA, Hudson KR, Heath JK",
    "reference": {
        "type": "PubMed",
        "id": "10026196",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10026196"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P47873-1",
            "protein_name": "Interleukin-11",
            "gene_name": "Il11",
            "tax_name": "Mouse"
        }
    ],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P47873",
                    "url": "https://www.uniprot.org/uniprot/P47873"
                }
            ],
            "common_name": "Mouse",
            "glygen_name": "Mouse",
            "reference_species": "Mus musculus [10090]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 168,
            "end_pos": 168,
            "sequence_org": "W",
            "sequence_mut": "A",
            "comment": "Slightly increases IL11RA binding. Abolishes interaction with IL6ST. Abolishes stimulation of cell proliferation.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P47873",
                    "url": "https://www.uniprot.org/uniprot/P47873"
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            "uniprot_canonical_ac": "P47873-1"
        },
        {
            "start_pos": 172,
            "end_pos": 172,
            "sequence_org": "R",
            "sequence_mut": "A",
            "comment": "No effect on IL11RA binding. Decreases stimulation of cell proliferation.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P47873",
                    "url": "https://www.uniprot.org/uniprot/P47873"
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                {
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                }
            ],
            "uniprot_canonical_ac": "P47873-1"
        },
        {
            "start_pos": 190,
            "end_pos": 190,
            "sequence_org": "R",
            "sequence_mut": "A",
            "comment": "Srongly reduces IL11RA binding and stimulation of cell proliferation.",
            "evidence": [
                {
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                    "id": "P47873",
                    "url": "https://www.uniprot.org/uniprot/P47873"
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            "start_pos": 193,
            "end_pos": 193,
            "sequence_org": "L",
            "sequence_mut": "A",
            "comment": "Impairs IL11RA binding and mildly reduces stimulation of cell proliferation.",
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    ],
    "record_id": "pubmed.10026196",
    "abstract": "",
    "glycosylation": [],
    "snv": [],
    "phosphorylation": [],
    "glycation": [],
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