{
    "title": "Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation.",
    "journal": "Oncogene",
    "date": "1999",
    "authors": "Elly C, Witte S, Zhang Z, Rosnet O, Lipkowitz S, Altman A, Liu YC",
    "reference": {
        "type": "PubMed",
        "id": "10022120",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10022120"
    },
    "referenced_glycans": [],
    "referenced_proteins": [
        {
            "uniprot_canonical_ac": "P62993-1",
            "protein_name": "Growth factor receptor-bound protein 2",
            "gene_name": "GRB2",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P46109-1",
            "protein_name": "Crk-like protein",
            "gene_name": "CRKL",
            "tax_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q13191-1",
            "protein_name": "E3 ubiquitin-protein ligase CBL-B",
            "gene_name": "CBLB",
            "tax_name": "Human"
        }
    ],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P62993",
                    "url": "https://www.uniprot.org/uniprot/P62993"
                }
            ],
            "common_name": "Human",
            "glygen_name": "Human",
            "reference_species": "Homo sapiens [9606]"
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 298,
            "end_pos": 298,
            "sequence_org": "G",
            "sequence_mut": "E",
            "comment": "Inhibits interaction with SYK. No effect on E3 activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q13191",
                    "url": "https://www.uniprot.org/uniprot/Q13191"
                },
                {
                    "database": "PubMed",
                    "id": "10022120",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10022120"
                },
                {
                    "database": "PubMed",
                    "id": "11087752",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/11087752"
                }
            ],
            "uniprot_canonical_ac": "Q13191-1"
        },
        {
            "start_pos": 665,
            "end_pos": 665,
            "sequence_org": "Y",
            "sequence_mut": "F",
            "comment": "Slightly inhibits interaction with CRKL. Abolishes interaction with CRKL; when associated with F-709.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q13191",
                    "url": "https://www.uniprot.org/uniprot/Q13191"
                },
                {
                    "database": "PubMed",
                    "id": "10022120",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10022120"
                }
            ],
            "uniprot_canonical_ac": "Q13191-1"
        },
        {
            "start_pos": 709,
            "end_pos": 709,
            "sequence_org": "Y",
            "sequence_mut": "F",
            "comment": "Inhibits interaction with CRKL. Abolishes interaction with CRKL; when associated with F-665.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q13191",
                    "url": "https://www.uniprot.org/uniprot/Q13191"
                },
                {
                    "database": "PubMed",
                    "id": "10022120",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10022120"
                }
            ],
            "uniprot_canonical_ac": "Q13191-1"
        }
    ],
    "phosphorylation": [
        {
            "start_pos": 665,
            "end_pos": 665,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Tyr",
            "comment": "Phosphotyrosine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q13191",
                    "url": "https://www.uniprot.org/uniprot/Q13191"
                },
                {
                    "database": "PubMed",
                    "id": "10022120",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10022120"
                },
                {
                    "database": "IntAct",
                    "id": "Q13191",
                    "url": "https://www.ebi.ac.uk/intact/interactors/id:Q13191*"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q13191",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q13191"
                },
                {
                    "database": "PubMed",
                    "id": "12842890",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/12842890"
                }
            ],
            "site_lbl": "Tyr665",
            "uniprot_canonical_ac": "Q13191-1"
        },
        {
            "start_pos": 709,
            "end_pos": 709,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Tyr",
            "comment": "Phosphotyrosine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q13191",
                    "url": "https://www.uniprot.org/uniprot/Q13191"
                },
                {
                    "database": "PubMed",
                    "id": "10022120",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/10022120"
                },
                {
                    "database": "IntAct",
                    "id": "Q13191",
                    "url": "https://www.ebi.ac.uk/intact/interactors/id:Q13191*"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q13191",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q13191"
                },
                {
                    "database": "PubMed",
                    "id": "12842890",
                    "url": "https://pubmed.ncbi.nlm.nih.gov/12842890"
                }
            ],
            "site_lbl": "Tyr709",
            "uniprot_canonical_ac": "Q13191-1"
        }
    ],
    "record_id": "pubmed.10022120",
    "abstract": "",
    "glycosylation": [],
    "snv": [],
    "glycation": [],
    "section_stats": [
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