{
    "uniprot_canonical_ac": "A0A1P8AVS2-1",
    "uniprot_ac": "A0A1P8AVS2",
    "uniprot_id": "A0A1P8AVS2_ARATH",
    "mass": {
        "chemical_mass": 45592.0,
        "monoisotopic_mass": 45592.0
    },
    "refseq": {
        "ac": "NP_565041",
        "name": "NagB/RpiA/CoA transferase-like superfamily protein",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_565041"
    },
    "gene_names": [
        {
            "name": "T10D10.19; T10D10_19",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_565041",
            "id": "NP_565041"
        },
        {
            "name": "T10D10.19",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1P8AVS2",
            "id": "A0A1P8AVS2"
        },
        {
            "name": "T10D10_19",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1P8AVS2",
            "id": "A0A1P8AVS2"
        }
    ],
    "protein_names": [
        {
            "name": "Translation initiation factor eIF2B subunit alpha",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprotkb/A0A1P8AVS2/entry#names_and_taxonomy",
            "id": "A0A1P8AVS2"
        },
        {
            "name": "NagB/RpiA/CoA transferase-like superfamily protein",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_565041",
            "id": "NP_565041"
        },
        {
            "name": "eIF2B GDP-GTP exchange factor subunit alpha",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A0A1P8AVS2/entry#names_and_taxonomy",
            "id": "A0A1P8AVS2"
        }
    ],
    "function": [],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Arabidopsis thaliana",
            "taxid": 3702,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1P8AVS2",
                    "url": "https://www.uniprot.org/uniprot/A0A1P8AVS2"
                }
            ],
            "common_name": "Mouse-ear cress",
            "glygen_name": "Arabidopsis",
            "reference_species": "Arabidopsis thaliana [3702]"
        }
    ],
    "gene": [
        {
            "name": "",
            "url": "https://www.uniprot.org/uniprot/A0A1P8AVS2",
            "locus": {}
        }
    ],
    "crossref": [
        {
            "id": "A0A1P8AVS2",
            "url": "https://alphafold.ebi.ac.uk/entry/A0A1P8AVS2",
            "database": "AlphaFoldDB",
            "categories": []
        },
        {
            "id": "AT1G72340",
            "url": "https://bar.utoronto.ca/thalemine/portal.do?externalids=AT1G72340",
            "database": "Araport",
            "categories": [
                "Organism-specific",
                "Protein"
            ]
        },
        {
            "id": "843566",
            "url": "https://www.ncbi.nlm.nih.gov/gene/843566",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "A0A1P8AVS2",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A0A1P8AVS2*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "Q8W4G0",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q8W4G0*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR000649",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000649",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR037171",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR037171",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR042528",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR042528",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR042529",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR042529",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR051501",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR051501",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "ath:AT1G72340",
            "url": "https://www.genome.jp/dbget-bin/www_bget?ath:AT1G72340",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "A0A1P8AVS2",
            "url": "https://www.orthodb.org/?gene=A0A1P8AVS2",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR45860",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45860",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR45860:SF3",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45860:SF3",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF01008",
            "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01008",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_565041",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_565041",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "AT1G72340",
            "url": "https://www.arabidopsis.org/servlets/TairObject?type=locus&name=AT1G72340",
            "database": "TAIR",
            "categories": [
                "Organism-specific",
                "Protein"
            ]
        },
        {
            "id": "A0A1P8AVQ1",
            "url": "https://www.uniprot.org/uniprot/A0A1P8AVQ1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1P8AVQ1-1",
            "url": "https://www.uniprot.org/uniprot/A0A1P8AVQ1-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1P8AVS2",
            "url": "https://www.uniprot.org/uniprot/A0A1P8AVS2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1P8AVS2-1",
            "url": "https://www.uniprot.org/uniprot/A0A1P8AVS2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8W4G0",
            "url": "https://www.uniprot.org/uniprot/Q8W4G0",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8W4G0-1",
            "url": "https://www.uniprot.org/uniprot/Q8W4G0-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
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        "sequence": "MIFLEKATVYYLQFFHFEEFSQEKKKSMWRRSPSFILDERRSSNSPPMADTTRGPFQNPDSISAYYQTRAAHHGVITSDWLAQAQAAVGGVSGDAQHDLSVTDLGNEKSFNVIEEFNNWRKQPDLAEAVAAIRALAAVIRASEASTMMELEIELKKASDTLKSWDKTSISLTAGCDLFIRYVTRTSALEYEDFNSAKSRLLERAEKFGEISCKARRIIAMLSQDFIFDGCTILVHGLSRVVLEILKTAAQNNKLFRVLCTEGRPDGTGVLLSSELSKLDIPVKLLLDSAVAYSMDEVDMVFVGADGVVESGGIINMMGTYQIALVAHSMNKPVYVAAESYKFARLYPLDQKDMAPALRPIEFGVKIPTKVEVERSARDYTPPQYLTLLFTDLGVLSPSVVSDELIQLYL",
        "length": 409,
        "header": "tr|A0A1P8AVS2-1|A0A1P8AVS2_ARATH Isoform 1 of Translation initiation factor eIF2B subunit alpha  OS=Arabidopsis thaliana OX=3702 GN= PE=1 SV=1 CANONICAL=A0A1P8AVS2-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A1P8AVQ1-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A1P8AVS2/entry#A0A1P8AVQ1-1",
            "sequence": {
                "sequence": "MWRRSPSFILDERRSSNSPPMADTTRGPFQNPDSISAYYQTRAAHHGVITSDWLAQAQAAVGGVSGDAQHDLSVTDLGNEKSFNVIEEFNNWRKQPDLAEAVAAIRALAAVIRASEASTMMELEIELKKASDTLKSWDKTSISLTAGCDLFIRYVTRTSALEYEDFNSAKSRLLERAEKFGEISCKARRIIAMLSQDFIFDGCTILVHGLSRVVLEILKTAAQNNKLFRVLCTEGRPDGTGVLLSSELSKLDIPVKLLLDSAVAYSMDEVDMVFVGADGVVESGGIINMMGTYQIALVAHSMNKPVYVAAESYKVIETVL",
                "length": 320,
                "header": "tr|A0A1P8AVQ1-1|A0A1P8AVS2_ARATH Computationally mapped isoform of Translation initiation factor eIF2B subunit alpha  OS=Arabidopsis thaliana OX=3702 GN= PE=1 SV=1 CANONICAL=A0A1P8AVS2-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 27238223,
                "end_pos": 27236898,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "AT1G72340.3",
                        "url": "https://www.ensemblgenomes.org/id/AT1G72340.3"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "AT1G72340.3",
                        "url": "https://www.ensemblgenomes.org/id/AT1G72340.3"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A1P8AVS2-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A1P8AVS2/entry#A0A1P8AVS2-1",
            "sequence": {
                "sequence": "MIFLEKATVYYLQFFHFEEFSQEKKKSMWRRSPSFILDERRSSNSPPMADTTRGPFQNPDSISAYYQTRAAHHGVITSDWLAQAQAAVGGVSGDAQHDLSVTDLGNEKSFNVIEEFNNWRKQPDLAEAVAAIRALAAVIRASEASTMMELEIELKKASDTLKSWDKTSISLTAGCDLFIRYVTRTSALEYEDFNSAKSRLLERAEKFGEISCKARRIIAMLSQDFIFDGCTILVHGLSRVVLEILKTAAQNNKLFRVLCTEGRPDGTGVLLSSELSKLDIPVKLLLDSAVAYSMDEVDMVFVGADGVVESGGIINMMGTYQIALVAHSMNKPVYVAAESYKFARLYPLDQKDMAPALRPIEFGVKIPTKVEVERSARDYTPPQYLTLLFTDLGVLSPSVVSDELIQLYL",
                "length": 409,
                "header": "tr|A0A1P8AVS2-1|A0A1P8AVS2_ARATH Isoform 1 of Translation initiation factor eIF2B subunit alpha  OS=Arabidopsis thaliana OX=3702 GN= PE=1 SV=1 CANONICAL=A0A1P8AVS2-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 27238479,
                "end_pos": 27236817,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "AT1G72340.2",
                        "url": "https://www.ensemblgenomes.org/id/AT1G72340.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "AT1G72340.2",
                        "url": "https://www.ensemblgenomes.org/id/AT1G72340.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8W4G0-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A1P8AVS2/entry#Q8W4G0-1",
            "sequence": {
                "sequence": "MWRRSPSFILDERRSSNSPPMADTTRGPFQNPDSISAYYQTRAAHHGVITSDWLAQAQAAVGGVSGDAQHDLSVTDLGNEKSFNVIEEFNNWRKQPDLAEAVAAIRALAAVIRASEASTMMELEIELKKASDTLKSWDKTSISLTAGCDLFIRYVTRTSALEYEDFNSAKSRLLERAEKFGEISCKARRIIAMLSQDFIFDGCTILVHGLSRVVLEILKTAAQNNKLFRVLCTEGRPDGTGVLLSSELSKLDIPVKLLLDSAVAYSMDEVDMVFVGADGVVESGGIINMMGTYQIALVAHSMNKPVYVAAESYKFARLYPLDQKDMAPALRPIEFGVKIPTKVEVERSARDYTPPQYLTLLFTDLGVLSPSVVSDELIQLYL",
                "length": 382,
                "header": "tr|Q8W4G0-1|A0A1P8AVS2_ARATH Computationally mapped isoform of Translation initiation factor eIF2B subunit alpha  OS=Arabidopsis thaliana OX=3702 GN= PE=1 SV=1 CANONICAL=A0A1P8AVS2-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 27238479,
                "end_pos": 27236898,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "AT1G72340.1",
                        "url": "https://www.ensemblgenomes.org/id/AT1G72340.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "AT1G72340.1",
                        "url": "https://www.ensemblgenomes.org/id/AT1G72340.1"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 34,
            "end_pos": 34,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "Q8W4G0",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8W4G0"
                },
                {
                    "database": "PubMed",
                    "id": "19376835",
                    "url": "https://glygen.org/publication/PubMed/19376835"
                }
            ],
            "site_lbl": "Ser34"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.",
            "journal": "Nature",
            "date": "2000",
            "authors": "Theologis A, Ecker J R, Palm C J, Federspiel N A, Kaul S, White O, Alonso J, Altafi H, Araujo R, Bowman C L, Brooks S Y, Buehler E, Chan A, Chao Q, Chen H, Cheuk R F, Chin C W, Chung M K, Conn L, Conway A B, Conway A R, Creasy T H, Dewar K, Dunn P, Etgu P, Feldblyum T V, Feng J, Fong B, Fujii C Y, Gill J E, Goldsmith A D, Haas B, Hansen N F, Hughes B, Huizar L, Hunter J L, Jenkins J, Johnson-Hopson C, Khan S, Khaykin E, Kim C J, Koo H L, Kremenetskaia I, Kurtz D B, Kwan A, Lam B, Langin-Hooper S, Lee A, Lee J M, Lenz C A, Li J H, Li Y, Lin X, Liu S X, Liu Z A, Luros J S, Maiti R, Marziali A, Militscher J, Miranda M, Nguyen M, Nierman W C, Osborne B I, Pai G, Peterson J, Pham P K, Rizzo M, Rooney T, Rowley D, Sakano H, Salzberg S L, Schwartz J R, Shinn P, Southwick A M, Sun H, Tallon L J, Tambunga G, Toriumi M J, Town C D, Utterback T, Van Aken S, Vaysberg M, Vysotskaia V S, Walker M, Wu D, Yu G, Fraser C M, Venter J C, Davis R W",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1P8AVQ1",
                    "url": "https://www.uniprot.org/uniprot/A0A1P8AVQ1"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11130712",
                    "url": "https://glygen.org/publication/PubMed/11130712"
                }
            ]
        },
        {
            "title": "Full-length messenger RNA sequences greatly improve genome annotation.",
            "journal": "Genome Biol.",
            "date": "2002",
            "authors": "Haas Brian J, Volfovsky Natalia, Town Christopher D, Troukhan Maxim, Alexandrov Nickolai, Feldmann Kenneth A, Flavell Richard B, White Owen, Salzberg Steven L",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8W4G0",
                    "url": "https://www.uniprot.org/uniprot/Q8W4G0"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12093376",
                    "url": "https://glygen.org/publication/PubMed/12093376"
                }
            ]
        },
        {
            "title": "Features of Arabidopsis genes and genome discovered using full-length cDNAs.",
            "journal": "Plant Mol. Biol.",
            "date": "2006",
            "authors": "Alexandrov Nickolai N, Troukhan Maxim E, Brover Vyacheslav V, Tatarinova Tatiana, Flavell Richard B, Feldmann Kenneth A",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8W4G0",
                    "url": "https://www.uniprot.org/uniprot/Q8W4G0"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16463100",
                    "url": "https://glygen.org/publication/PubMed/16463100"
                }
            ]
        },
        {
            "title": "Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks.",
            "journal": "Plant Physiol.",
            "date": "2009",
            "authors": "Reiland Sonja, Messerli Ga\u00eblle, Baerenfaller Katja, Gerrits Bertran, Endler Anne, Grossmann Jonas, Gruissem Wilhelm, Baginsky Sacha",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1P8AVQ1",
                    "url": "https://www.uniprot.org/uniprot/A0A1P8AVQ1"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q8W4G0",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8W4G0"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19376835",
                    "url": "https://glygen.org/publication/PubMed/19376835"
                }
            ]
        },
        {
            "title": "Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.",
            "journal": "Plant J.",
            "date": "2017",
            "authors": "Cheng Chia-Yi, Krishnakumar Vivek, Chan Agnes P, Thibaud-Nissen Fran\u00e7oise, Schobel Seth, Town Christopher D",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1P8AVQ1",
                    "url": "https://www.uniprot.org/uniprot/A0A1P8AVQ1"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "27862469",
                    "url": "https://glygen.org/publication/PubMed/27862469"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "ath:AT1G72340",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/www_bget?ath:AT1G72340",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
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                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1P8AVS2",
                                "url": "https://www.uniprot.org/uniprot/A0A1P8AVS2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "eukaryotic translation initiation factor 2B complex",
                        "id": "GO:0005851",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005851",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1P8AVS2",
                                "url": "https://www.uniprot.org/uniprot/A0A1P8AVS2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "transferase activity",
                        "id": "GO:0016740",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016740",
                        "evidence": [
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                                "database": "UniProtKB",
                                "id": "A0A1P8AVS2",
                                "url": "https://www.uniprot.org/uniprot/A0A1P8AVS2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "translation initiation factor activity",
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                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1P8AVS2",
                                "url": "https://www.uniprot.org/uniprot/A0A1P8AVS2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 1,
                "go_terms": [
                    {
                        "name": "translational initiation",
                        "id": "GO:0006413",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006413",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1P8AVS2",
                                "url": "https://www.uniprot.org/uniprot/A0A1P8AVS2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "structures": [
        {
            "pdb_id": "AF-A0A1P8AVS2-F1",
            "pdb_chain": "global",
            "start_pos": 1,
            "end_pos": 409,
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