{
    "uniprot_canonical_ac": "A0A1P8ASY1-1",
    "uniprot_ac": "A0A1P8ASY1",
    "uniprot_id": "JHS1_ARATH",
    "mass": {
        "chemical_mass": 147286.0,
        "monoisotopic_mass": 147286.0
    },
    "refseq": {
        "ac": "NP_001184943",
        "name": "DNA replication helicase",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184943"
    },
    "gene_names": [
        {
            "name": "EMB2411",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1",
            "id": "A0A1P8ASY1"
        },
        {
            "name": "JHS1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1",
            "id": "A0A1P8ASY1"
        },
        {
            "name": "EMB2411",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1",
            "id": "A0A1P8ASY1"
        },
        {
            "name": "F7G19.26",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1",
            "id": "A0A1P8ASY1"
        },
        {
            "name": "emb2411",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184943",
            "id": "NP_001184943"
        },
        {
            "name": "emb2411",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1",
            "id": "A0A1P8ASY1"
        },
        {
            "name": "embryo defective 2411",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184943",
            "id": "NP_001184943"
        },
        {
            "name": "embryo defective 2411",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1",
            "id": "A0A1P8ASY1"
        }
    ],
    "protein_names": [
        {
            "name": "DNA replication ATP-dependent helicase/nuclease JHS1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprotkb/A0A1P8ASY1/entry#names_and_taxonomy",
            "id": "A0A1P8ASY1"
        },
        {
            "name": "DNA replication helicase",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184943",
            "id": "NP_001184943"
        },
        {
            "name": "Protein EMBRYO DEFECTIVE 2411",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A0A1P8ASY1/entry#names_and_taxonomy",
            "id": "A0A1P8ASY1"
        },
        {
            "name": "Protein JING HE SHENG 1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A0A1P8ASY1/entry#names_and_taxonomy",
            "id": "A0A1P8ASY1"
        }
    ],
    "function": [
        {
            "annotation": "Essential protein required during embryogenesis (PubMed:15266054). Key enzyme involved in DNA replication and damage repair, shoot apical meristem (SAM) maintenance, and development (PubMed:26951435). Involved in Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is atypical: it cannot load onto its tracking strand internally and has an absolute free 5'-end requirement (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1P8ASY1",
                    "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1#function"
                },
                {
                    "database": "PubMed",
                    "id": "26951435",
                    "url": "https://glygen.org/publication/PubMed/26951435"
                },
                {
                    "database": "PubMed",
                    "id": "15266054",
                    "url": "https://glygen.org/publication/PubMed/15266054"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q9URU2",
                    "url": "https://www.uniprot.org/uniprot/Q9URU2#function"
                }
            ]
        },
        {
            "annotation": "Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "F4HXR5",
                    "url": "https://www.uniprot.org/uniprot/F4HXR5#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "RU367041",
                    "url": "https://www.uniprot.org/uniprot/RU367041#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Arabidopsis thaliana",
            "taxid": 3702,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1P8ASY1",
                    "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1"
                }
            ],
            "common_name": "Mouse-ear cress",
            "glygen_name": "Arabidopsis",
            "reference_species": "Arabidopsis thaliana [3702]"
        }
    ],
    "gene": [
        {
            "name": "JHS1",
            "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1",
            "locus": {}
        }
    ],
    "crossref": [
        {
            "id": "A0A1P8ASY1",
            "url": "https://alphafold.ebi.ac.uk/entry/A0A1P8ASY1",
            "database": "AlphaFoldDB",
            "categories": []
        },
        {
            "id": "AT1G08840",
            "url": "https://bar.utoronto.ca/thalemine/portal.do?externalids=AT1G08840",
            "database": "Araport",
            "categories": [
                "Organism-specific",
                "Protein"
            ]
        },
        {
            "id": "cd18041",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18041",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd18808",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18808",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd22318",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22318",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "837406",
            "url": "https://www.ncbi.nlm.nih.gov/gene/837406",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR011604",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011604",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR014808",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR014808",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR026851",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR026851",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR027417",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR041677",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR041677",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR041679",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR041679",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR045055",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR045055",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR047187",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR047187",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR051827",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR051827",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "ath:AT1G08840",
            "url": "https://www.genome.jp/dbget-bin/www_bget?ath:AT1G08840",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "NYCEAAI",
            "url": "https://omabrowser.org/oma/group/NYCEAAI/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "A0A1P8ASY1",
            "url": "https://www.orthodb.org/?gene=A0A1P8ASY1",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10887",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10887",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10887:SF433",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10887:SF433",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR36531",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36531",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR36531:SF6",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36531:SF6",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF08696",
            "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08696",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF13086",
            "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13086",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF13087",
            "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13087",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_A0A1P8ASY1",
            "url": "http://purl.obolibrary.org/obo/PR_A0A1P8ASY1",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_001184943",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184943",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "13065",
            "url": "https://www.rhea-db.org/rhea/13065",
            "database": "Rhea",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "AT1G08840",
            "url": "https://www.arabidopsis.org/servlets/TairObject?type=locus&name=AT1G08840",
            "database": "TAIR",
            "categories": [
                "Organism-specific",
                "Protein"
            ]
        },
        {
            "id": "A0A1P8ASU0",
            "url": "https://www.uniprot.org/uniprot/A0A1P8ASU0",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1P8ASU0-1",
            "url": "https://www.uniprot.org/uniprot/A0A1P8ASU0-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1P8ASY1",
            "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1P8ASY1-1",
            "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1P8ASY1-2",
            "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1P8ASY1-3",
            "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1-3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F4HXR5",
            "url": "https://www.uniprot.org/uniprot/F4HXR5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F4HXR5-1",
            "url": "https://www.uniprot.org/uniprot/F4HXR5-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MPPRKKPKSSALKSNKQSSANHSSQPSTFGIQQLFLRHIQNSQSTSNSHTSTADPVDQQNVNGLASDTAVLTPQNPLGTSNEKPDESKDMDQQLTEASPKISKNLKRFSPGMLIKQSQDDCGGEITWKISPVNERLRAAAKNIPKMMDLTENSLGVKSSTIRPCSLNKLVQKQCPTSGITSKVEQWLSSPSKKASKRPAFATNRVMERVNPSPDAEFEIVNTSSSGNSPFQTPPSLSCPHNKLPCTVTCSGACGSMGAGQHKKALLELLDQVEDVIAVDDKTTDDVGIVMPQARVKDDIISSVVDCAVDEGPVSLPKMQNSINPDSYFLVLEVSEKRGSGSSSKGQCPYKVLRLLDEHTGVECALYLWDEWFYSTVSPGDSINVIGEFDGDGKCDVDRQNNFLIVHPDTLVAGTRVAASFGCPRRTVLDERLRSNEHATVALLGTLQHQVFQAGLSQESPSVDGLQEYASTVIEKSIESLYACGVHEGDVRSTLFKAIPKMLNWIEHFRYSKDSEVSKVDFGSTIGKKAVKVSEVIDIEEMSWAPKYGLKGMIDASVRVIVESDMNTVNEKIMPLEFKSGKAPSGQSSIEHSAQVILYTLLMSERYLKHIDNGLLYYLQSDQTQGISVQRSDLVGLIIRRNELANDILVASTTQQLPPMLRNPNICRNCRHLDVCTIYHKADGGNTESSGLGDVFDTHVSHLSTLHFNFLRHWDRLIDLEGREMQLLRKDIAHPHGSKGSHSASYLSSMVLDVTNGFQHHNSHKETRFIYRFVRQKSSESRERVTSEDMIRTGNLATDDLDCKLRTGDRVILRTEVSHLTVANGIIADISRTHISVSLSKRLRLPWSEPSSEVSNLSHELWRIYKDEFMTSFSVMRFNLMQLFVQNGHNIRKMIVDLEPPRFDNGSILSQDPAISYIWSEKSLNNDQRQAILKILTAKDYALILGMPGTGKTSTMVHAVKALLIRGSSILLASYTNSAVDNLLIKLKAQGIEFLRIGRDEAVHEEVRESCFSAMNMCSVEDIKKKLDQVKVVASTCLGINSPLLVNRRFDVCIIDEAGQIALPVSIGPLLFASTFVLVGDHYQLPPLVQSTEARENGMGISLFRRLSEAHPQAISVLQNQYRMCRGIMELSNALIYGDRLCCGSAEVADATLVLSTSSSTSPWLKKVLEPTRTVVFVNTDMLRAFEARDQNAINNPVEASIIAEIVEELVNNGVDSKDIGIITPYNSQASLIQHAIPTTPVEIHTIDKYQGRDKDCILVSFVRSREKPRSSASSLLGDWHRINVALTRAKKKLIMVGSQRTLSRVPLLMLLLNKVKEQSGILNLLPGDLKP",
        "length": 1331,
        "header": "sp|A0A1P8ASY1-1|JHS1_ARATH Isoform 1 of DNA replication ATP-dependent helicase/nuclease JHS1  OS=Arabidopsis thaliana OX=3702 GN=JHS1 PE=2 SV=1 CANONICAL=A0A1P8ASY1-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A1P8ASU0-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A1P8ASY1/entry#A0A1P8ASU0-1",
            "sequence": {
                "sequence": "MPPRKKPKSSALKSNKQSSANHSSQPSTFGIQQLFLRHIQNSQSTSNSHTSTADPVDQQNVNGLASDTAVLTPQNPLGTSNEKPDESKDMDQQLTEASPKISKNLKRFSPGMLIKQSQDDCGGEITWKISPVNERLRAAAKNIPKMMDLTENSLGKQCPTSGITSKVEQWLSSPSKKASKRPAFATNRVMERVNPSPDAEFEIVNTSSSGNSPFQTPPSLSCPHNKLPCTVTCSGACGSMGAGQHKKALLELLDQVEDVIAVDDKTTDDVGIVMPQARVKDDIISSVVDCAVDEGPVSLPKMQNSINPDSYFLVLEVSEKRGSGSSSKGQCPYKVLRLLDEHTGVECALYLWDEWFYSTVSPGDSINVIGEFDGDGKCDVDRQNNFLIVHPDTLVAGTRVAASFGCPRRTVLDERLRSNEHATVALLGTLQHQVFQAGLSQESPSVDGLQEYASTVIEKSIESLYACGVHEGDVRSTLFKAIPKMLNWIEHFRYSKDSEVSKVDFGSTIGKKAVKVSEVIDIEEMSWAPKYGLKGMIDASVRVIVESDMNTVNEKIMPLEFKSGKAPSGQSSIEHSAQVILYTLLMSERYLKHIDNGLLYYLQSDQTQGISVQRSDLVGLIIRRNELANDILVASTTQQLPPMLRNPNICRNCRHLDVCTIYHKADGGNTESSGLGDVFDTHVSHLSTLHFNFLRHWDRLIDLEGREMQLLRKDIAHPHGSKGSHSASYLSSMVLDVTNGFQHHNSHKETRFIYRFVRQKSSESRERVTSEDMIRTGNLATDDLDCKLRTGDRVILRTEVSHLTVANGIIADISRTHISVSLSKRLRLPWSEPSSEVSNLSHELWRIYKDEFMTSFSVMRFNLMQLFVQNGHNIRKMIVDLEPPRFDNGSILSQDPAISYIWSEKSLNNDQRQAILKILTAKDYALILGMPGTGKTSTMVHAVKALLIRGSSILLASYTNSAVDNLLIKLKAQGIEFLRIGRDEAVHEEVRESCFSAMNMCSVEDIKKKLDQVKVVASTCLGINSPLLVNRRFDVCIIDEAGQIALPV",
                "length": 1048,
                "header": "tr|A0A1P8ASU0-1|A0A1P8ASU0_ARATH Computationally mapped isoform of DNA helicase  OS=Arabidopsis thaliana OX=3702 GN=EMB2411 PE=1 SV=1 CANONICAL=A0A1P8ASY1-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 2838369,
                "end_pos": 2831466,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "AT1G08840.5",
                        "url": "https://www.ensemblgenomes.org/id/AT1G08840.5"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "AT1G08840.5",
                        "url": "https://www.ensemblgenomes.org/id/AT1G08840.5"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A1P8ASY1-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A1P8ASY1/entry#A0A1P8ASY1-1",
            "sequence": {
                "sequence": "MPPRKKPKSSALKSNKQSSANHSSQPSTFGIQQLFLRHIQNSQSTSNSHTSTADPVDQQNVNGLASDTAVLTPQNPLGTSNEKPDESKDMDQQLTEASPKISKNLKRFSPGMLIKQSQDDCGGEITWKISPVNERLRAAAKNIPKMMDLTENSLGVKSSTIRPCSLNKLVQKQCPTSGITSKVEQWLSSPSKKASKRPAFATNRVMERVNPSPDAEFEIVNTSSSGNSPFQTPPSLSCPHNKLPCTVTCSGACGSMGAGQHKKALLELLDQVEDVIAVDDKTTDDVGIVMPQARVKDDIISSVVDCAVDEGPVSLPKMQNSINPDSYFLVLEVSEKRGSGSSSKGQCPYKVLRLLDEHTGVECALYLWDEWFYSTVSPGDSINVIGEFDGDGKCDVDRQNNFLIVHPDTLVAGTRVAASFGCPRRTVLDERLRSNEHATVALLGTLQHQVFQAGLSQESPSVDGLQEYASTVIEKSIESLYACGVHEGDVRSTLFKAIPKMLNWIEHFRYSKDSEVSKVDFGSTIGKKAVKVSEVIDIEEMSWAPKYGLKGMIDASVRVIVESDMNTVNEKIMPLEFKSGKAPSGQSSIEHSAQVILYTLLMSERYLKHIDNGLLYYLQSDQTQGISVQRSDLVGLIIRRNELANDILVASTTQQLPPMLRNPNICRNCRHLDVCTIYHKADGGNTESSGLGDVFDTHVSHLSTLHFNFLRHWDRLIDLEGREMQLLRKDIAHPHGSKGSHSASYLSSMVLDVTNGFQHHNSHKETRFIYRFVRQKSSESRERVTSEDMIRTGNLATDDLDCKLRTGDRVILRTEVSHLTVANGIIADISRTHISVSLSKRLRLPWSEPSSEVSNLSHELWRIYKDEFMTSFSVMRFNLMQLFVQNGHNIRKMIVDLEPPRFDNGSILSQDPAISYIWSEKSLNNDQRQAILKILTAKDYALILGMPGTGKTSTMVHAVKALLIRGSSILLASYTNSAVDNLLIKLKAQGIEFLRIGRDEAVHEEVRESCFSAMNMCSVEDIKKKLDQVKVVASTCLGINSPLLVNRRFDVCIIDEAGQIALPVSIGPLLFASTFVLVGDHYQLPPLVQSTEARENGMGISLFRRLSEAHPQAISVLQNQYRMCRGIMELSNALIYGDRLCCGSAEVADATLVLSTSSSTSPWLKKVLEPTRTVVFVNTDMLRAFEARDQNAINNPVEASIIAEIVEELVNNGVDSKDIGIITPYNSQASLIQHAIPTTPVEIHTIDKYQGRDKDCILVSFVRSREKPRSSASSLLGDWHRINVALTRAKKKLIMVGSQRTLSRVPLLMLLLNKVKEQSGILNLLPGDLKP",
                "length": 1331,
                "header": "sp|A0A1P8ASY1-1|JHS1_ARATH Isoform 1 of DNA replication ATP-dependent helicase/nuclease JHS1  OS=Arabidopsis thaliana OX=3702 GN=JHS1 PE=2 SV=1 CANONICAL=A0A1P8ASY1-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 2838369,
                "end_pos": 2829582,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "AT1G08840.3",
                        "url": "https://www.ensemblgenomes.org/id/AT1G08840.3"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "AT1G08840.3",
                        "url": "https://www.ensemblgenomes.org/id/AT1G08840.3"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A1P8ASY1-2",
            "url": "https://www.uniprot.org/uniprotkb/A0A1P8ASY1/entry#A0A1P8ASY1-2",
            "sequence": {
                "sequence": "MPPRKKPKSSALKSNKQSSANHSSQPSTFGIQQLFLRHIQNSQSTSNSHTSTADPVDQQNVNGLASDTAVLTPQNPLGTSNEKPDESKDMDQQLTEASPKISKNLKRFSPGMLIKQSQDDCGGEITWKISPVNERLRAAAKNIPKMMDLTENSLGKQCPTSGITSKVEQWLSSPSKKASKRPAFATNRVMERVNPSPDAEFEIVNTSSSGNSPFQTPPSLSCPHNKLPCTVTCSGACGSMGAGQHKKALLELLDQVEDVIAVDDKTTDDVGIVMPQARVKDDIISSVVDCAVDEGPVSLPKMQNSINPDSYFLVLEVSEKRGSGSSSKGQCPYKVLRLLDEHTGVECALYLWDEWFYSTVSPGDSINVIGEFDGDGKCDVDRQNNFLIVHPDTLVAGTRVAASFGCPRRTVLDERLRSNEHATVALLGTLQHQVFQAGLSQESPSVDGLQEYASTVIEKSIESLYACGVHEGDVRSTLFKAIPKMLNWIEHFRYSKDSEVSKVDFGSTIGKKAVKVSEVIDIEEMSWAPKYGLKGMIDASVRVIVESDMNTVNEKIMPLEFKSGKAPSGQSSIEHSAQVILYTLLMSERYLKHIDNGLLYYLQSDQTQGISVQRSDLVGLIIRRNELANDILVASTTQQLPPMLRNPNICRNCRHLDVCTIYHKADGGNTESSGLGDVFDTHVSHLSTLHFNFLRHWDRLIDLEGREMQLLRKDIAHPHGSKGSHSASYLSSMVLDVTNGFQHHNSHKETRFIYRFVRQKSSESRERVTSEDMIRTGNLATDDLDCKLRTGDRVILRTEVSHLTVANGIIADISRTHISVSLSKRLRLPWSEPSSEVSNLSHELWRIYKDEFMTSFSVMRFNLMQLFVQNGHNIRKMIVDLEPPRFDNGSILSQDPAISYIWSEKSLNNDQRQAILKILTAKDYALILGMPGTGKTSTMVHAVKALLIRGSSILLASYTNSAVDNLLIKLKAQGIEFLRIGRDEAVHEEVRESCFSAMNMCSVEDIKKKLDQVKVVASTCLGINSPLLVNRRFDVCIIDEAGQIALPVSIGPLLFASTFVLVGDHYQLPPLVQSTEARENGMGISLFRRLSEAHPQAISVLQNQYRMCRGIMELSNALIYGDRLCCGSAEVADATLVLSTSSSTSPWLKKVLEPTRTVVFVNTDMLRAFEARDQNAINNPVEASIIAEIVEELVNNGVDSKDIGIITPYNSQASLIQHAIPTTPVEIHTIDKYQGRDKDCILVSFVRSREKPRSSASSLLGDWHRINVALTRAKKKLIMVGSQRTLSRVPLLMLLLNKVKEQSGILNLLPGDLKP",
                "length": 1315,
                "header": "sp|A0A1P8ASY1-2|JHS1_ARATH Isoform 2 of DNA replication ATP-dependent helicase/nuclease JHS1  OS=Arabidopsis thaliana OX=3702 GN=JHS1 PE=2 SV=1 CANONICAL=A0A1P8ASY1-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 2838369,
                "end_pos": 2829582,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "AT1G08840.2",
                        "url": "https://www.ensemblgenomes.org/id/AT1G08840.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "AT1G08840.2",
                        "url": "https://www.ensemblgenomes.org/id/AT1G08840.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A1P8ASY1-3",
            "url": "https://www.uniprot.org/uniprotkb/A0A1P8ASY1/entry#A0A1P8ASY1-3",
            "sequence": {
                "sequence": "MPPRKKPKSSALKSNKQSSANHSSQPSTFGIQQLFLRHIQNSQSTSNSHTSTADPVDQQNVNGLASDTAVLTPQNPLGTSNEKPDESKDMDQQLTEASPKISKNLKRFSPGMLIKQSQDDCGGEITWKISPVNERLRAAAKNIPKMMDLTENSLGVKSSTIRPCSLNKKQCPTSGITSKVEQWLSSPSKKASKRPAFATNRVMERVNPSPDAEFEIVNTSSSGNSPFQTPPSLSCPHNKLPCTVTCSGACGSMGAGQHKKALLELLDQVEDVIAVDDKTTDDVGIVMPQARVKDDIISSVVDCAVDEGPVSLPKMQNSINPDSYFLVLEVSEKRGSGSSSKGQCPYKVLRLLDEHTGVECALYLWDEWFYSTVSPGDSINVIGEFDGDGKCDVDRQNNFLIVHPDTLVAGTRVAASFGCPRRTVLDERLRSNEHATVALLGTLQHQVFQAGLSQESPSVDGLQEYASTVIEKSIESLYACGVHEGDVRSTLFKAIPKMLNWIEHFRYSKDSEVSKVDFGSTIGKKAVKVSEVIDIEEMSWAPKYGLKGMIDASVRVIVESDMNTVNEKIMPLEFKSGKAPSGQSSIEHSAQVILYTLLMSERYLKHIDNGLLYYLQSDQTQGISVQRSDLVGLIIRRNELANDILVASTTQQLPPMLRNPNICRNCRHLDVCTIYHKADGGNTESSGLGDVFDTHVSHLSTLHFNFLRHWDRLIDLEGREMQLLRKDIAHPHGSKGSHSASYLSSMVLDVTNGFQHHNSHKETRFIYRFVRQKSSESRERVTSEDMIRTGNLATDDLDCKLRTGDRVILRTEVSHLTVANGIIADISRTHISVSLSKRLRLPWSEPSSEVSNLSHELWRIYKDEFMTSFSVMRFNLMQLFVQNGHNIRKMIVDLEPPRFDNGSILSQDPAISYIWSEKSLNNDQRQAILKILTAKDYALILGMPGTGKTSTMVHAVKALLIRGSSILLASYTNSAVDNLLIKLKAQGIEFLRIGRDEAVHEEVRESCFSAMNMCSVEDIKKKLDQVKVVASTCLGINSPLLVNRRFDVCIIDEAGQIALPVSIGPLLFASTFVLVGDHYQLPPLVQSTEARENGMGISLFRRLSEAHPQAISVLQNQYRMCRGIMELSNALIYGDRLCCGSAEVADATLVLSTSSSTSPWLKKVLEPTRTVVFVNTDMLRAFEARDQNAINNPVEASIIAEIVEELVNNGVDSKDIGIITPYNSQASLIQHAIPTTPVEIHTIDKYQGRDKDCILVSFVRSREKPRSSASSLLGDWHRINVALTRAKKKLIMVGSQRTLSRVPLLMLLLNKVKEQSGILNLLPGDLKP",
                "length": 1328,
                "header": "sp|A0A1P8ASY1-3|JHS1_ARATH Isoform 3 of DNA replication ATP-dependent helicase/nuclease JHS1  OS=Arabidopsis thaliana OX=3702 GN=JHS1 PE=2 SV=1 CANONICAL=A0A1P8ASY1-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 2838369,
                "end_pos": 2829582,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "AT1G08840.4",
                        "url": "https://www.ensemblgenomes.org/id/AT1G08840.4"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "AT1G08840.4",
                        "url": "https://www.ensemblgenomes.org/id/AT1G08840.4"
                    }
                ]
            }
        },
        {
            "isoform_ac": "F4HXR5-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A1P8ASY1/entry#F4HXR5-1",
            "sequence": {
                "sequence": "MPPRKKPKSSALKSNKQSSANHSSQPSTFGIQQLFLRHIQNSQSTSNSHTSTADPVDQQNVNGLASDTAVLTPQNPLGTSNEKPDESKDMDQQLTEASPKISKNLKRFSPGMLIKQSQDDCGGEITWKISPVNERLRAAAKNIPKMMDLTENSLGKQCPTSGITSKVEQWLSSPSKKASKRPAFATNRVMERVNPSPDAEFEIVNTSSSGNSPFQTPPSLSCPHNKLPCTVTCSGACGSMGAGQHKKALLELLDQVEDVIAVDDKTTDDVGIVMPQARVKDDIISSVVDCAVDEGPVSLPKMQNSINPDSYFLVLEVSEKRGSGSSSKGQCPYKVLRLLDEHTGVECALYLWDEWFYSTVSPGDSINVIGEFDGDGKCDVDRQNNFLIVHPDTLVAGTRVAASFGCPRRTVLDERLRSNEHATVALLGTLQHQVFQAGLSQESPSVDGLQEYASTVIEKSIESLYACGVHEGDVRSTLFKAIPKMLNWIEHFRYSKDSEVSKVDFGSTIGKKAVKVSEVIDIEEMSWAPKYGLKGMIDASVRVIVESDMNTVNEKIMPLEFKSGKAPSGQSSIEHSAQVILYTLLMSERYLKHIDNGLLYYLQSDQTQGISVQRSDLVGLIIRRNELANDILVASTTQQLPPMLRADGGNTESSGLGDVFDTHVSHLSTLHFNFLRHWDRLIDLEGREMQLLRKDIAHPHGSKGSHSASYLSSMVLDVTNGFQHHNSHKETRFIYRFVRQKSSESRERVTSEDMIRTGNLATDDLDCKLRTGDRVILRTEVSHLTVANGIIADISRTHISVSLSKRLRLPWSEPSSEVSNLSHELWRIYKDEFMTSFSVMRFNLMQLFVQNGHNIRKMIVDLEPPRFDNGSILSQDPAISYIWSEKSLNNDQRQAILKILTAKDYALILGMPGTGKTSTMVHAVKALLIRGSSILLASYTNSAVDNLLIKLKAQGIEFLRIGRDEAVHEEVRESCFSAMNMCSVEDIKKKLDQVKVVASTCLGINSPLLVNRRFDVCIIDEAGQIALPVSIGPLLFASTFVLVGDHYQLPPLVQSTEARENGMGISLFRRLSEAHPQAISVLQNQYRMCRGIMELSNALIYGDRLCCGSAEVADATLVLSTSSSTSPWLKKVLEPTRTVVFVNTDMLRAFEARDQNAINNPVEASIIAEIVEELVNNGVDSKDIGIITPYNSQASLIQHAIPTTPVEIHTIDKYQGRDKDCILVSFVRSREKPRSSASSLLGDWHRINVALTRAKKKLIMVGSQRTLSRVPLLMLLLNKVKEQSGILNLLPGDLKP",
                "length": 1296,
                "header": "tr|F4HXR5-1|F4HXR5_ARATH Computationally mapped isoform of DNA replication ATP-dependent helicase/nuclease  OS=Arabidopsis thaliana OX=3702 GN=EMB2411 PE=1 SV=1 CANONICAL=A0A1P8ASY1-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 2838369,
                "end_pos": 2829582,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "AT1G08840.1",
                        "url": "https://www.ensemblgenomes.org/id/AT1G08840.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "AT1G08840.1",
                        "url": "https://www.ensemblgenomes.org/id/AT1G08840.1"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 321,
            "end_pos": 321,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "A0A1P8ASY1",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0A1P8ASY1"
                }
            ],
            "site_lbl": "Ser321"
        },
        {
            "start_pos": 326,
            "end_pos": 326,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "A0A1P8ASY1",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0A1P8ASY1"
                }
            ],
            "site_lbl": "Ser326"
        },
        {
            "start_pos": 426,
            "end_pos": 426,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "A0A1P8ASY1",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0A1P8ASY1"
                },
                {
                    "database": "PubMed",
                    "id": "18463617",
                    "url": "https://glygen.org/publication/PubMed/18463617"
                },
                {
                    "database": "PubMed",
                    "id": "20466843",
                    "url": "https://glygen.org/publication/PubMed/20466843"
                }
            ],
            "site_lbl": "Thr426"
        }
    ],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [
        {
            "title": "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.",
            "journal": "Nature",
            "date": "2000",
            "authors": "Theologis A, Ecker J R, Palm C J, Federspiel N A, Kaul S, White O, Alonso J, Altafi H, Araujo R, Bowman C L, Brooks S Y, Buehler E, Chan A, Chao Q, Chen H, Cheuk R F, Chin C W, Chung M K, Conn L, Conway A B, Conway A R, Creasy T H, Dewar K, Dunn P, Etgu P, Feldblyum T V, Feng J, Fong B, Fujii C Y, Gill J E, Goldsmith A D, Haas B, Hansen N F, Hughes B, Huizar L, Hunter J L, Jenkins J, Johnson-Hopson C, Khan S, Khaykin E, Kim C J, Koo H L, Kremenetskaia I, Kurtz D B, Kwan A, Lam B, Langin-Hooper S, Lee A, Lee J M, Lenz C A, Li J H, Li Y, Lin X, Liu S X, Liu Z A, Luros J S, Maiti R, Marziali A, Militscher J, Miranda M, Nguyen M, Nierman W C, Osborne B I, Pai G, Peterson J, Pham P K, Rizzo M, Rooney T, Rowley D, Sakano H, Salzberg S L, Schwartz J R, Shinn P, Southwick A M, Sun H, Tallon L J, Tambunga G, Toriumi M J, Town C D, Utterback T, Van Aken S, Vaysberg M, Vysotskaia V S, Walker M, Wu D, Yu G, Fraser C M, Venter J C, Davis R W",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1P8ASY1",
                    "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11130712",
                    "url": "https://glygen.org/publication/PubMed/11130712"
                }
            ]
        },
        {
            "title": "Identification of genes required for embryo development in Arabidopsis.",
            "journal": "Plant physiology",
            "date": "2004-07",
            "authors": "Tzafrir Iris, Pena-Muralla Rosanna, Dickerman Allan, Berg Michael, Rogers Rebecca, Hutchens Steven, Sweeney T Colleen, McElver John, Aux George, Patton David, Meinke David",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1P8ASY1",
                    "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15266054",
                    "url": "https://glygen.org/publication/PubMed/15266054"
                }
            ]
        },
        {
            "title": "Large-scale phosphorylation mapping reveals the extent of tyrosine phosphorylation in Arabidopsis.",
            "journal": "Molecular systems biology",
            "date": "2008",
            "authors": "Sugiyama Naoyuki, Nakagami Hirofumi, Mochida Keiichi, Daudi Arsalan, Tomita Masaru, Shirasu Ken, Ishihama Yasushi",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "A0A1P8ASY1",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0A1P8ASY1"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "18463617",
                    "url": "https://glygen.org/publication/PubMed/18463617"
                }
            ]
        },
        {
            "title": "Large-scale comparative phosphoproteomics identifies conserved phosphorylation sites in plants.",
            "journal": "Plant physiology",
            "date": "2010-07",
            "authors": "Nakagami Hirofumi, Sugiyama Naoyuki, Mochida Keiichi, Daudi Arsalan, Yoshida Yuko, Toyoda Tetsuro, Tomita Masaru, Ishihama Yasushi, Shirasu Ken",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "A0A1P8ASY1",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A0A1P8ASY1"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "20466843",
                    "url": "https://glygen.org/publication/PubMed/20466843"
                }
            ]
        },
        {
            "title": "A DNA2 Homolog Is Required for DNA Damage Repair, Cell Cycle Regulation, and Meristem Maintenance in Plants.",
            "journal": "Plant physiology",
            "date": "2016-05",
            "authors": "Jia Ning, Liu Xiaomin, Gao Hongbo",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1P8ASY1",
                    "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "26951435",
                    "url": "https://glygen.org/publication/PubMed/26951435"
                }
            ]
        },
        {
            "title": "Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.",
            "journal": "Plant J.",
            "date": "2017",
            "authors": "Cheng Chia-Yi, Krishnakumar Vivek, Chan Agnes P, Thibaud-Nissen Fran\u00e7oise, Schobel Seth, Town Christopher D",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A1P8ASY1",
                    "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "27862469",
                    "url": "https://glygen.org/publication/PubMed/27862469"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "ath:AT1G08840",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/www_bget?ath:AT1G08840",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "E1BMP7-1",
            "protein_name": "DNA replication ATP-dependent helicase/nuclease DNA2",
            "gene_name": "DNA2",
            "tax_id": 9913,
            "organism": "Bos taurus",
            "sequence": {
                "sequence": "MERVDELELLMEKSFWQEAEPSAELFQKKKVEASFSKIVLSRGMDNRYLVLAVDIVQSEEGNHEKHLIITASQSLEYKELCILRNDWCSVPVEPGDIIHLEGDCISNTWIIDEDFGYLILYPDMLISGTSIASSIRCMRRAVLSETFRSSDPATRQMLIGTVLHEVFQKAVSDSFAPEKLQELASQTIQEIRHLKEMYRLKLNQDEIKQEVEEYLPSFSKWAGDFMHKHTSTDFPQMQLSLPSDGSNSNSTCNIEVTNSLDIEESIWSPRFGLKGKIDVTVGVKIHRGCKTKYKIMPLELKTGKESNSIEHRSQLVLYTLLSQERRADPEAGLLLYLKTGQMYPVPAKHLDKRELLRLRNQMAFSLFHRINKSTGEKTELAPLPQIIEEQQTCKYCSQMGNCALYSRAVEQQMEDSSVPTSMWPKIKEETQHLKPIHLEYFSLWCLMLTLESQSKDNKRNYQHIWLMPASEMEESGSCIGSLIRIEHVKTVCDGQYLHNFQRKNGAIPITNLMAGDRIILSGEERTLFALSRGYVKEINSTTVTCSLDRNLSGLPESTLFRLDQEEKNCDIDTPLGNLSKLMENTRASQKLRDLIIDFREPQFISYLSSVLPHEAKDTVACILKGLNKPQRQAMKKVLLSKDYTLIVGMPGTGKTTTICTLVRILYACGFSVLLTSYTHSAVDNILLKLAKFKIGFLRLGQIQKVHPDIQKFTEEEICRSKSIKSLALLEELYNSQLIVATTCMGINHPIFSRKTFDFCIVDEASQISQPVCLGPLFFSRRFVLVGDHQQLPPLVLNREARALGMSESLFKRLEQNKNAVVQLTVQYRMNSKIMSLSNKLTYEGKLECGSDKVANAVINLPNFKDVKLELEFYADYSENPWLIAAFEPNNPVCFLNTHKVPAPEQVEKGGVSNIMEAKLVVFLTSVFIKAGCKPSDIGIIAPYRQQLKVISDLLAQSSVGMVEVNTVDRYQGRDKSIVVVSFVRSNEDGTLGELLKDWRRLNVAITRAKHKLILLGCVPSLSRYPPLRKLLNHLNSEKLIIDLPSGEHESLFHLLGDFQRK",
                "length": 1061
            },
            "evidence": [
                {
                    "id": "A0A1P8ASY1",
                    "url": "https://omabrowser.org/oma/group/A0A1P8ASY1/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Bovine",
            "common_name": "Bovine"
        },
        {
            "uniprot_canonical_ac": "P38859-1",
            "protein_name": "DNA replication ATP-dependent helicase/nuclease DNA2",
            "gene_name": "DNA2",
            "tax_id": 559292,
            "organism": "Saccharomyces cerevisiae S288C",
            "sequence": {
                "sequence": "MPGTPQKNKRSASISVSPAKKTEEKEIIQNDSKAILSKQTKRKKKYAFAPINNLNGKNTKVSNASVLKSIAVSQVRNTSRTKDINKAVSKSVKQLPNSQVKPKREMSNLSRHHDFTQDEDGPMEEVIWKYSPLQRDMSDKTTSAAEYSDDYEDVQNPSSTPIVPNRLKTVLSFTNIQVPNADVNQLIQENGNEQVRPKPAEISTRESLRNIDDILDDIEGDLTIKPTITKFSDLPSSPIKAPNVEKKAEVNAEEVDKMDSTGDSNDGDDSLIDILTQKYVEKRKSESQITIQGNTNQKSGAQESCGKNDNTKSRGEIEDHENVDNQAKTGNAFYENEEDSNCQRIKKNEKIEYNSSDEFSDDSLIELLNETQTQVEPNTIEQDLDKVEKMVSDDLRIATDSTLSAYALRAKSGAPRDGVVRLVIVSLRSVELPKIGTQKILECIDGKGEQSSVVVRHPWVYLEFEVGDVIHIIEGKNIENKRLLSDDKNPKTQLANDNLLVLNPDVLFSATSVGSSVGCLRRSILQMQFQDPRGEPSLVMTLGNIVHELLQDSIKYKLSHNKISMEIIIQKLDSLLETYSFSIIICNEEIQYVKELVMKEHAENILYFVNKFVSKSNYGCYTSISGTRRTQPISISNVIDIEENIWSPIYGLKGFLDATVEANVENNKKHIVPLEVKTGKSRSVSYEVQGLIYTLLLNDRYEIPIEFFLLYFTRDKNMTKFPSVLHSIKHILMSRNRMSMNFKHQLQEVFGQAQSRFELPPLLRDSSCDSCFIKESCMVLNKLLEDGTPEESGLVEGEFEILTNHLSQNLANYKEFFTKYNDLITKEESSITCVNKELFLLDGSTRESRSGRCLSGLVVSEVVEHEKTEGAYIYCFSRRRNDNNSQSMLSSQIAANDFVIISDEEGHFCLCQGRVQFINPAKIGISVKRKLLNNRLLDKEKGVTTIQSVVESELEQSSLIATQNLVTYRIDKNDIQQSLSLARFNLLSLFLPAVSPGVDIVDERSKLCRKTKRSDGGNEILRSLLVDNRAPKFRDANDDPVIPYKLSKDTTLNLNQKEAIDKVMRAEDYALILGMPGTGKTTVIAEIIKILVSEGKRVLLTSYTHSAVDNILIKLRNTNISIMRLGMKHKVHPDTQKYVPNYASVKSYNDYLSKINSTSVVATTCLGINDILFTLNEKDFDYVILDEASQISMPVALGPLRYGNRFIMVGDHYQLPPLVKNDAARLGGLEESLFKTFCEKHPESVAELTLQYRMCGDIVTLSNFLIYDNKLKCGNNEVFAQSLELPMPEALSRYRNESANSKQWLEDILEPTRKVVFLNYDNCPDIIEQSEKDNITNHGEAELTLQCVEGMLLSGVPCEDIGVMTLYRAQLRLLKKIFNKNVYDGLEILTADQFQGRDKKCIIISMVRRNSQLNGGALLKELRRVNVAMTRAKSKLIIIGSKSTIGSVPEIKSFVNLLEERNWVYTMCKDALYKYKFPDRSNAIDEARKGCGKRTGAKPITSKSKFVSDKPIIKEILQEYES",
                "length": 1522
            },
            "evidence": [
                {
                    "id": "A0A1P8ASY1",
                    "url": "https://omabrowser.org/oma/group/A0A1P8ASY1/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Yeast",
            "common_name": "Baker's yeast"
        },
        {
            "uniprot_canonical_ac": "P51530-1",
            "protein_name": "DNA replication ATP-dependent helicase/nuclease DNA2",
            "gene_name": "DNA2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MEQLNELELLMEKSFWEEAELPAELFQKKVVASFPRTVLSTGMDNRYLVLAVNTVQNKEGNCEKRLVITASQSLENKELCILRNDWCSVPVEPGDIIHLEGDCTSDTWIIDKDFGYLILYPDMLISGTSIASSIRCMRRAVLSETFRSSDPATRQMLIGTVLHEVFQKAINNSFAPEKLQELAFQTIQEIRHLKEMYRLNLSQDEIKQEVEDYLPSFCKWAGDFMHKNTSTDFPQMQLSLPSDNSKDNSTCNIEVVKPMDIEESIWSPRFGLKGKIDVTVGVKIHRGYKTKYKIMPLELKTGKESNSIEHRSQVVLYTLLSQERRADPEAGLLLYLKTGQMYPVPANHLDKRELLKLRNQMAFSLFHRISKSATRQKTQLASLPQIIEEEKTCKYCSQIGNCALYSRAVEQQMDCSSVPIVMLPKIEEETQHLKQTHLEYFSLWCLMLTLESQSKDNKKNHQNIWLMPASEMEKSGSCIGNLIRMEHVKIVCDGQYLHNFQCKHGAIPVTNLMAGDRVIVSGEERSLFALSRGYVKEINMTTVTCLLDRNLSVLPESTLFRLDQEEKNCDIDTPLGNLSKLMENTFVSKKLRDLIIDFREPQFISYLSSVLPHDAKDTVACILKGLNKPQRQAMKKVLLSKDYTLIVGMPGTGKTTTICTLVRILYACGFSVLLTSYTHSAVDNILLKLAKFKIGFLRLGQIQKVHPAIQQFTEQEICRSKSIKSLALLEELYNSQLIVATTCMGINHPIFSRKIFDFCIVDEASQISQPICLGPLFFSRRFVLVGDHQQLPPLVLNREARALGMSESLFKRLEQNKSAVVQLTVQYRMNSKIMSLSNKLTYEGKLECGSDKVANAVINLRHFKDVKLELEFYADYSDNPWLMGVFEPNNPVCFLNTDKVPAPEQVEKGGVSNVTEAKLIVFLTSIFVKAGCSPSDIGIIAPYRQQLKIINDLLARSIGMVEVNTVDKYQGRDKSIVLVSFVRSNKDGTVGELLKDWRRLNVAITRAKHKLILLGCVPSLNCYPPLEKLLNHLNSEKLIIDLPSREHESLCHILGDFQRE",
                "length": 1060
            },
            "evidence": [
                {
                    "id": "A0A1P8ASY1",
                    "url": "https://omabrowser.org/oma/group/A0A1P8ASY1/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Human",
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q6ZQJ5-1",
            "protein_name": "DNA replication ATP-dependent helicase/nuclease DNA2",
            "gene_name": "Dna2",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MEPLDELDLLLLEEDGGAEAVPRVELLRKKADALFPETVLSRGVDNRYLVLAVETSQNERGAEEKRLHVTASQDREHEVLCILRNGWSSVPVEPGDIVHLEGDCTSEPWIIDDDFGYFILYPDMMISGTSVASSIRCLRRAVLSETFRGSDPATRQMLIGTILHEVFQKAISESFAPERLQELALQTLREVRHLKEMYRLNLSQDEILCEVEEYLPSFSKWAEDFMRKGPSSEFPQMQLSLPSDGSNRSSPCNIEVVKSLDIEESIWSPRFGLKGKIDVTVGVKIHRDCKMKYKVMPLELKTGKESNSIEHRSQVVLYTLLSQERREDPEAGWLLYLKTGQMYPVPANHLDKRELLKLRNWLAASLLHRVSRAAPGEEARLSALPQIIEEEKTCKYCSQIGNCALYSRAVEEQGDDASIPEAMLSKIQEETRHLQLAHLKYFSLWCLMLTLESQSKDNRKTHQSIWLTPASELEESGNCVGNLVRTEPVSRVCDGQYLHNFQRKNGPMPATNLMAGDRIILSGEERKLFALSKGYVKKMNKAAVTCLLDRNLSTLPATTVFRLDREERHGDISTPLGNLSKLMESTDPSKRLRELIIDFREPQFIAYLSSVLPHDAKDTVANILKGLNKPQRQAMKRVLLSKDYTLIVGMPGTGKTTTICALVRILSACGFSVLLTSYTHSAVDNILLKLAKFKVGFLRLGQSHKVHPDIQKFTEEEICRSRSIASLAHLEELYNSHPIVATTCMGINHPIFSRKTFDFCIVDEASQISQPVCLGPLFFSRRFVLVGDHQQLPPLVVNREARALGMSESLFKRLERNESAVVQLTVQYRMNRKIMSLSNKLTYAGKLECGSDRVANAVLALPNLKDARLSLQLYADYSDSPWLAGVLEPDNPVCFLNTDKVPAPEQVENGGVSNVTEARLIVFLTSTFIKAGCSPSDIGVIAPYRQQLRIISDLLARSSVGMVEVNTVDKYQGRDKSLILVSFVRSNEDGTLGELLKDWRRLNVALTRAKHKLILLGSVSSLKRFPPLGTLFDHLNAEQLILDLPSREHESLSHILGDCQRD",
                "length": 1062
            },
            "evidence": [
                {
                    "id": "A0A1P8ASY1",
                    "url": "https://omabrowser.org/oma/group/A0A1P8ASY1/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Mouse",
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q8IRL9-1",
            "protein_name": "DNA replication ATP-dependent helicase/nuclease",
            "gene_name": "Dna2",
            "tax_id": 7227,
            "organism": "Drosophila melanogaster",
            "sequence": {
                "sequence": "MATKRVLTPNILENDNTDVTSSNPQKKFKEQLDFSSDEVENIDWGDNDDFDLALIAAMDSISNHRLELTKWQRCEVVRLEQLPNRKGLKVHVKRISGGDPETADCQLLPPWNCMPMQVGDTVSLLGKWDPSAGCYVVDKEQGYCVSHPDFLISGTTVTGSLFCKRKSVLQERFRGLDSGNSVMVIGTLVHELLQKVLRQKLFDKKHIQSALQEMLASSSLAHLLYASNLIQVEMEDHLMKFIDPIVSFVAQYVKGEPPSVLLPEVYRGQIHEICDIEENLWVPQLGLKGKVDVSVKVKNQRQREEIIPLELKTGRASFSMEHKGQLLLYQLMHSAQGRDTQSGLLLYLKEGLLREVASGRNEQRDLLMLRNDLAYWLTREVAIPASKEDPLEQLPLPEPVYHHSACGNCAYNTICSSFAQKDSSLQLSDSHPLKKLMPQLLEHLSEADHAYVQHWCGLLALEEQHNRQSSHVRSFWTKDPAEREKEGIAIRHLKLVKGQEVILEEGRYRQTLELGEEADPSRDLSLSGFDLGEYVVISSTSRLAVAAGFIVSIEARRLDLRLERDLSQRYSEETFIIDKHDSQSFATFNFTNLGMLLSEGERFQELRDIIVAKKPPEQHKVLPKIILTKGAPILLNLNKVQQNAALRALTTSSHLLIKGLPGTGKTQTLVALVRLLHLLGKSVLITAQTHSAVDNLIMRLLPFGLPMMRLGSGSRIHKQLEEISEERLTKDCKTVEELEKALGQPSIVGVTCLGCGHPLFQRRQFDYCIVDEATQVLQPTVLRPLIHCSKFVLVGDPEQLPPIVRSKEARQRGADETLFQRLDSEKATAVLSLQYRMNKTITRLANELTYGGDLKCASDEVSGARFEVELLNEAPRWVQRALTTHLEQAVTLINTGDCLERCQEFVYASQRLVDTCSSIEQSFSEDKDEIRKLTSKKRVSKYTNYCEAGIVMHLLRYLLKSGYEASRIGVIAPYRAQVELFKKLASKLDTDLECNTVDQFQGRDKNLIIYSCSKTGGDFSDMERSREAEILEDQRRLTVAITRAKNKLILLGDIKCLEQYGPFRQLFKHIPDRCRLKLEEGRMEFGWQRIQEDLVGLMDT",
                "length": 1100
            },
            "evidence": [
                {
                    "id": "A0A1P8ASY1",
                    "url": "https://omabrowser.org/oma/group/A0A1P8ASY1/",
                    "database": "OMA"
                }
            ],
            "glygen_name": "Fruit fly",
            "common_name": "Fruit fly"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 9,
                "go_terms": [
                    {
                        "name": "DNA binding",
                        "id": "GO:0003677",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1P8ASY1",
                                "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ATP binding",
                        "id": "GO:0005524",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1P8ASY1",
                                "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "metal ion binding",
                        "id": "GO:0046872",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1P8ASY1",
                                "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "4 iron, 4 sulfur cluster binding",
                        "id": "GO:0051539",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051539",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1P8ASY1",
                                "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ATP hydrolysis activity",
                        "id": "GO:0016887",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1P8ASY1",
                                "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nuclease activity",
                        "id": "GO:0004518",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004518",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1P8ASY1",
                                "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "single-stranded DNA helicase activity",
                        "id": "GO:0017116",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017116",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1P8ASY1",
                                "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "5'-flap endonuclease activity",
                        "id": "GO:0017108",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017108",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1P8ASY1",
                                "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "helicase activity",
                        "id": "GO:0004386",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004386",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1P8ASY1",
                                "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1P8ASY1",
                                "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "chromosome",
                        "id": "GO:0005694",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1P8ASY1",
                                "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 5,
                "go_terms": [
                    {
                        "name": "DNA repair",
                        "id": "GO:0006281",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1P8ASY1",
                                "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA replication",
                        "id": "GO:0006260",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006260",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1P8ASY1",
                                "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA damage response",
                        "id": "GO:0006974",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1P8ASY1",
                                "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "meristem maintenance",
                        "id": "GO:0010073",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010073",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1P8ASY1",
                                "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA replication, Okazaki fragment processing",
                        "id": "GO:0033567",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033567",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A1P8ASY1",
                                "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 21,
            "end_pos": 23,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 221,
            "end_pos": 223,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 855,
            "end_pos": 857,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 904,
            "end_pos": 906,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [
        {
            "id": "13065",
            "name": "",
            "equation": "ATP + H2O = ADP + H(+) + phosphate",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "O80786-1",
                "P0CJ46-1",
                "P53492-1",
                "A0A1P8ASY1-1",
                "B5X582-1",
                "B9DFG3-1",
                "D1KF50-1",
                "F4HQE2-1",
                "F4IDQ6-1",
                "F4IE66-1",
                "F4J9M5-1",
                "F4JAA5-1",
                "F4K128-1",
                "F4K2E9-1",
                "F4KAB8-1",
                "Q6EVK6-1",
                "P41376-1",
                "P42762-1",
                "P43299-1",
                "Q0WVF5-1",
                "Q0WVW7-1",
                "Q38861-1",
                "Q7X9V2-1",
                "Q8GYD9-1",
                "Q8H0U8-1",
                "Q8H136-1",
                "Q8L7S8-1",
                "Q8L840-1",
                "Q8RXK6-1",
                "Q8RXS6-1",
                "Q8VY00-1",
                "Q8VZG2-1",
                "Q8W4E1-1",
                "Q93ZG7-1",
                "Q96292-1",
                "Q9FT69-1",
                "Q96293-1",
                "Q9FJI1-1",
                "Q9FJR0-1",
                "Q9FL33-1",
                "Q9FMR9-1",
                "Q9FNP1-1",
                "Q9FT70-1",
                "Q9FT72-1",
                "Q9FT74-1",
                "Q9FUG4-1",
                "Q5D892-1",
                "Q9FT73-1",
                "Q94A52-1",
                "Q9CAI7-1",
                "Q9FLD5-1",
                "Q9FQ08-1",
                "Q9FQ09-1",
                "Q56XG6-1",
                "Q9LPD9-1",
                "Q9LT02-1",
                "Q9LUW6-1",
                "Q9M0Y8-1",
                "Q9SF37-1",
                "Q9SIY3-1",
                "Q9SL02-1",
                "Q9SMX1-1",
                "Q9SXJ7-1",
                "Q9SYP1-1",
                "Q9XFH4-1",
                "Q9XIF2-1",
                "Q9ZNT0-1",
                "F4IJV4-1",
                "F4INA9-1",
                "F4JEX5-1",
                "F4KFV7-1",
                "I3XHK1-1",
                "P0CJ47-1",
                "P41377-1",
                "P53494-1",
                "P53496-1",
                "P53497-1",
                "P93008-1",
                "Q38953-1",
                "Q39189-1",
                "Q56X76-1",
                "Q9ZVW2-1",
                "Q8GY84-1",
                "Q94BV4-1",
                "Q84W89-1",
                "Q8GUG7-1",
                "Q8LA13-1",
                "Q8RY16-1",
                "Q8W4R3-1",
                "Q94C75-1",
                "F4HYJ7-1",
                "Q7XJN0-1",
                "F4I9Q5-1",
                "F4IFF3-1",
                "F4IJ77-1",
                "F4ILR7-1",
                "F4IM84-1",
                "F4INY4-1",
                "F4IQG2-1",
                "Q9LYJ9-1",
                "Q9M2E0-1",
                "Q9SA27-1",
                "Q9SB89-1",
                "Q9LFN6-1",
                "Q9FNM7-1",
                "Q9LUW5-1",
                "F4JRJ6-1",
                "O22243-1",
                "Q84TG1-1",
                "F4JFJ3-1",
                "F4JMJ3-1",
                "F4KGU4-1",
                "O22899-1",
                "O22907-1",
                "O48534-1",
                "O49289-1",
                "P0CE10-1",
                "Q3E9C3-1",
                "Q3EBD3-1",
                "Q7FGZ2-1",
                "Q8GW96-1",
                "Q8GXD6-1",
                "Q9LZQ9-1",
                "Q9LH83-1",
                "Q93Y16-1",
                "Q93Y39-1",
                "Q944S1-1",
                "Q9C551-1",
                "Q9C6G0-1",
                "Q9C718-1",
                "Q9C813-1",
                "Q9C8J1-1",
                "Q9C8S9-1",
                "Q9FFQ1-1",
                "Q9FFT9-1",
                "Q9FJW0-1",
                "Q9FLB0-1",
                "Q9FN75-1",
                "Q9FNQ1-1",
                "Q9FVV4-1",
                "Q9FZ92-1",
                "Q9LH82-1",
                "Q9LH84-1",
                "Q9LIH9-1",
                "Q9LJJ7-1",
                "Q9LP11-1",
                "Q9SF41-1",
                "Q9LU46-1",
                "Q9M2F9-1",
                "Q9M2X5-1",
                "Q9SQV1-1",
                "Q9SW44-1",
                "Q9SZB4-1",
                "Q9ZRZ8-1",
                "Q9CA92-1",
                "F4JPK8-1",
                "Q147F9-1",
                "Q8RY66-1",
                "Q9FF84-1",
                "F4J0C0-1",
                "F4J0B7-1",
                "Q9LFR5-1",
                "F4KFX5-1",
                "F4KID5-1",
                "O80792-1",
                "Q9FN78-1",
                "Q9FKM3-1",
                "Q9FN77-1",
                "Q9LJJ5-1",
                "Q8W4M7-1"
            ],
            "evidence": [
                {
                    "id": "13065",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/13065"
                }
            ]
        }
    ],
    "reaction_participants": [],
    "reaction_enzymes": [
        {
            "uniprot_ac": "A0A1P8ASY1",
            "gene_name": "JHS1",
            "activity": [
                {
                    "ec_number": "3.1.-.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "A0A1P8ASY1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.4.12",
                    "activity": "ATP + H2O = ADP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "A0A1P8ASY1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.4.12",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "A0A1P8ASY1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A0A1P8ASY1"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "B5X582",
            "gene_name": "",
            "activity": [
                {
                    "ec_number": "2.7.7.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "B5X582",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/B5X582"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.4.12",
                    "activity": "ATP + H2O = ADP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "B5X582",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/B5X582"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "B9DFG3",
            "gene_name": "ISE2",
            "activity": [
                {
                    "ec_number": "3.6.4.13",
                    "activity": "ATP + H2O = ADP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "B9DFG3",
                            "database": "UniProtKB",
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                    "ec_number": "3.6.4.13",
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                    "ec_number": "3.6.4.13",
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                {
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                            "id": "Q9FJI1",
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                    "ec_number": "3.6.4.13",
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                            "id": "Q9FVV4",
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                    "ec_number": "3.6.4.13",
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                            "id": "Q9FVV4",
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                    "ec_number": "3.6.4.13",
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