{ "uniprot_canonical_ac": "A0A1F4-1", "uniprot_ac": "A0A1F4", "uniprot_id": "EYS_DROME", "mass": { "chemical_mass": 234104.0, "monoisotopic_mass": 234104.0 }, "refseq": { "ac": "NP_001027571", "name": "eyes shut, isoform F", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027571" }, "gene_names": [ { "name": "eys", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A1F4", "id": "A0A1F4" }, { "name": "21A6; CG15388; CG15389; CG33955; CG7245; CT35437; Dmel\\CG33955; Eyes Shut; Eys; EYS; mAb 21A6; mAb21A6; MAb21A6; spacemaker; spam; Spam; SPAM", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027571", "id": "NP_001027571" }, { "name": "21A6", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A1F4", "id": "A0A1F4" }, { "name": "CG15388", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A1F4", "id": "A0A1F4" }, { "name": "CG15389", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A1F4", "id": "A0A1F4" }, { "name": "CG33955", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A1F4", "id": "A0A1F4" }, { "name": "CG7245", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A1F4", "id": "A0A1F4" }, { "name": "CT35437", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A1F4", "id": "A0A1F4" }, { "name": "Dmel\\CG33955", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A1F4", "id": "A0A1F4" }, { "name": "Dmel_CG33955", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A1F4", "id": "A0A1F4" }, { "name": "EYS", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A1F4", "id": "A0A1F4" }, { "name": "Eyes Shut", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A1F4", "id": "A0A1F4" }, { "name": "Eys", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A1F4", "id": "A0A1F4" }, { "name": "MAb21A6", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A1F4", "id": "A0A1F4" }, { "name": "SPAM", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A1F4", "id": "A0A1F4" }, { "name": "Spam", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A1F4", "id": "A0A1F4" }, { "name": "eys", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027571", "id": "NP_001027571" }, { "name": "mAb 21A6", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A1F4", "id": "A0A1F4" }, { "name": "mAb21A6", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A1F4", "id": "A0A1F4" }, { "name": "spacemaker", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A1F4", "id": "A0A1F4" }, { "name": "spam", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A1F4", "id": "A0A1F4" } ], "protein_names": [ { "name": "Protein eyes shut", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A1F4/entry#names_and_taxonomy", "id": "A0A1F4" }, { "name": "CG33955-PF; eys-PF; agrin-like; eyes shut; fibropellin; spacemaker; spam; eyeshut; Eye shut", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027571", "id": "NP_001027571" }, { "name": "Protein spacemaker", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1F4/entry#names_and_taxonomy", "id": "A0A1F4" }, { "name": "eyes shut, isoform F", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027571", "id": "NP_001027571" } ], "function": [ { "annotation": "Essential for the formation of matrix-filled interrhabdomeral space: critical for the formation of epithelial lumina in the retina. Acts together with prominin (prom) and the cell adhesion molecule chaoptin (chp) to choreograph the partitioning of rhabdomeres into an open system.", "evidence": [ { "database": "UniProtKB", "id": "A0A1F4", "url": "https://www.uniprot.org/uniprot/A0A1F4#function" }, { "database": "PubMed", "id": "17036004", "url": "https://glygen.org/publication/PubMed/17036004" }, { "database": "PubMed", "id": "17011488", "url": "https://glygen.org/publication/PubMed/17011488" } ] } ], "disease": [ { "disease_id": "DOID:0050572", "recommended_name": { "id": "DOID:0050572", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050572", "name": "cone-rod dystrophy", "description": "A retinal degeneration that characterized by progressive deterioration of the cone and rod photoreceptor cells." }, "synonyms": [ { "id": "DOID:0050572", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050572", "name": "cone-rod retinal dystrophy", "description": "" } ], "evidence": [ { "id": "0050572", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050572" } ] }, { "disease_id": "DOID:0110384", "recommended_name": { "id": "DOID:0110384", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110384", "name": "retinitis pigmentosa 25", "description": "A retinitis pigmentosa that has_material_basis_in mutation in the EYS gene on chromosome 6q12." }, "synonyms": [ { "id": "DOID:0110384", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110384", "name": "RP25", "description": "" }, { "id": "MONDO:0011272", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011272", "name": "retinitis pigmentosa 25", "description": "Any retinitis pigmentosa in which the cause of the disease is a mutation in the EYS gene." }, { "id": "MONDO:0011272", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011272", "name": "EYS retinitis pigmentosa", "description": "" }, { "id": "MONDO:0011272", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011272", "name": "RP25", "description": "" }, { "id": "MONDO:0011272", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011272", "name": "retinitis pigmentosa 25", "description": "" }, { "id": "MONDO:0011272", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011272", "name": "retinitis pigmentosa caused by mutation in EYS", "description": "" }, { "id": "MONDO:0011272", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011272", "name": "retinitis pigmentosa type 25", "description": "" }, { "id": "MONDO:0011272", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011272", "name": "RP 25", "description": "" }, { "id": "MIM:602772", "resource": "MIM", "url": "https://www.omim.org/entry/602772", "name": "Retinitis pigmentosa 25", "description": "Retinitis pigmentosa 25" } ], "evidence": [ { "id": "0110384", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0110384" } ] }, { "disease_id": "DOID:10584", "recommended_name": { "id": "DOID:10584", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10584", "name": "retinitis pigmentosa", "description": "A retinal degeneration characterized by the gradual deterioration of the photoreceptors or the retinal pigment epithelium of the retina leading to progressive sight loss." }, "synonyms": [ { "id": "DOID:10584", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10584", "name": "pericentral pigmentary retinopathy", "description": "" }, { "id": "MONDO:0019200", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019200", "name": "retinitis pigmentosa", "description": "Retinitis pigmentosa (RP) is an inherited retinal dystrophy leading to progressive loss of the photoreceptors and retinal pigment epithelium and resulting in blindness usually after several decades." }, { "id": "MONDO:0019200", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019200", "name": "retinitis pigmentosa", "description": "" }, { "id": "MONDO:0019200", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019200", "name": "pericentral pigmentary retinopathy", "description": "" }, { "id": "MONDO:0019200", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019200", "name": "Rod-cone dystrophy", "description": "" }, { "id": "MIM:268000", "resource": "MIM", "url": "https://www.omim.org/entry/268000", "name": "Retinitis pigmentosa", "description": "Retinitis pigmentosa" } ], "evidence": [ { "id": "10584", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10584" } ] }, { "disease_id": "DOID:8466", "recommended_name": { "id": "DOID:8466", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8466", "name": "retinal degeneration", "description": "A retinal disease that is characterized by deterioration of the retina caused by the progressive and eventual death of the cells of the retina." }, "synonyms": [ { "id": "DOID:8466", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8466", "name": "degeneration of retina", "description": "" } ], "evidence": [ { "id": "8466", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:8466" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 521, "end_pos": 521, "sequence_org": "E", "sequence_mut": "K", "comment": "In eys(734); fails to form an interrhabdomeral space.", "evidence": [ { "database": "UniProtKB", "id": "A0A1F4", "url": "https://www.uniprot.org/uniprot/A0A1F4" }, { "database": "PubMed", "id": "17011488", "url": "https://glygen.org/publication/PubMed/17011488" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "A0A1F4", "url": "https://www.uniprot.org/uniprot/A0A1F4" } ], "common_name": "Fruit fly", "glygen_name": "Fruit fly", "reference_species": "Drosophila melanogaster [7227]" } ], "gene": [ { "name": "eys", "url": "https://www.uniprot.org/uniprot/A0A1F4", "locus": { "chromosome": "2L", "start_pos": 2358944, "end_pos": 2311680, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0031414", "url": "https://www.ensemblgenomes.org/id/FBgn0031414" } ] } } ], "crossref": [ { "id": "A0A1F4", "url": "https://alphafold.ebi.ac.uk/entry/A0A1F4", "database": "AlphaFoldDB", "categories": [] }, { "id": "FBgn0031414", "url": "https://bgee.org/?page=gene&gene_id=FBgn0031414", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00110", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00110", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "FBgn0031414", "url": "https://flybase.org/reports/FBgn0031414", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "3771890", "url": "https://www.ncbi.nlm.nih.gov/gene/3771890", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001791", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001791", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013032", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013032", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051830", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051830", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG33955", "url": "https://www.genome.jp/dbget-bin/www_bget?dme:Dmel_CG33955", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FYCEIAL", "url": "https://omabrowser.org/oma/group/FYCEIAL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A1F4", "url": "https://www.orthodb.org/?gene=A0A1F4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "M9PBU9", "url": "https://www.orthodb.org/?gene=M9PBU9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24033", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24033", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24033:SF235", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24033:SF235", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00008", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00008", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02210", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02210", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12661", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12661", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_A0A1F4", "url": "http://purl.obolibrary.org/obo/PR_A0A1F4", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001027571", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027571", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A1F4", "url": "https://www.uniprot.org/uniprot/A0A1F4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1F4-1", "url": "https://www.uniprot.org/uniprot/A0A1F4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M9PBU9", "url": "https://www.uniprot.org/uniprot/M9PBU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M9PBU9-1", "url": "https://www.uniprot.org/uniprot/M9PBU9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSNVHQFDTQTMAESPQIRRDMGRLCATWPSKDSEDGAGTALRAATPLTANGATTTGLSVTLAPKDMQRNHLLKMPTATIEKPTITATIASSSSTSTSTTRKSVTATRSLKLNPNILLPTLRILARGLLLPALILAILVGSSQAGFACLSNPCVFGVCIDGLNSSYSCYCIDGYTGIQCQTNWDECWSSPCQNGGTCVDGVAYYNCTCPEGFSGSNCEENVDECMSNPCQNGGLCRDRTNGYICTCQPGYLGSHCELDVAVCETGTGARCQHGGECIEGPGLEFTCDCPAGWHGRICQEEINECASSPCQNGGVCVDKLAAYACACPMGYTGINCEEEILICADNPCQNNALCLMEEGVPTCYCVPDYHGEKCEFQYDECQLGPRCMNGGVCIDGVDTFSCSCPPLLTGMLCECLMVGEESLDCNYTAPATQSPPRRTTTTSTMAPPTVRPVTPPETTVSPSRASEEVEIIVVTTSAPAEVVTSVLSPSSSSSSSEEGVSVEIKTPTVAPPESGSHSISVEQTTAVPAQPEPESEQEPESKPHPESESASESETETEEEIIPGTTARPPTSRSSSSSEESPSIFTTLPPLPGKPQTSASSESSGEVVTSEEYTTVPHFEVSGSKSESGSEEVTTVRPTAAPSITISVDITSSGSSSSSSESVEVFTTPAPVFVQRVTTIETSISIDYVTPTPLPETTTPRVVPVPRPTFAPEPPLDVVETTASTHHLWTEVPTTAAPFFTEYPAEVLITTHRTSAGRFTTVQPPAGVTTTSPTEDSSVELPTPHTPQIVVTILDSNEVIPSLITTTGSPTTHHHHHHHPHHEAEGTTLQPLEEDEHHHHHHHDEFTTPQPVEITTGHPLQTEDLIGVQEPAVVTTESPFAPAETTVVPVVVPATIAPLGTAAPPATPAPVPPATTTPPPSPPSLATETPTLPPTLPPVTLPPVTQPPPTIPPTPPSTQSAQTLPPPTSAINVYTTPDGPPTASQTKPSVTESSEEVEGTNTVSTGGRGSGGVPEEKAGDVDCIKLGCYNGGTCVTTSEGSRCVCRFDRQGPLCELPIIIRNAAFSGDSYVSHRIYKDIGGHESLDAVLPMHIQLKVRTRATNGLIMLAAAQGTKGGHYMALFLQKGLMQFQFSCGLQTMLLSELETPVNTGHEITIRAELDFSRNYTHCNASLLVNDTLAMSGDQPTWLKLLPPRLHTPEAILNTWLHLGGAPQAPIGLIIELPPAQSGSGFTGCLHTLRINGQAREIFGDALDGFGITECGSLACLSSPCRNGAACIKIETNDLDENGEKAEKWKCKCPTGYMGPTCEISVCEDNPCQYGGTCVQFPGSGYLCLCPLGKHGHYCEHNLEVALPSFSGSVNGLSSFVAYTVPIPLEYSLELSFKILPQTMSQISLLAFFGQSGYHDEKSDHLAVSFIQGYIMLTWNLGAGPRRIFTQKPIDFRLDAPRVPYEIKVGRIGRQAWLSVDGKFNITGRSPGSGSRMDVLPILYLGGHEIANFNTLPHDLPLHSGFQGCIYDVQLKAGQVTVPLQETRGVRGRGVGQCGTRECHRHACQHDGACLQHGATFTCICQEGWYGPLCAQPTNPCDSFNNKCYEDATCVPLVNGYECDCPVGRTGKNCEEVIRSLSDVSLTGRRSYLAVRWPYLYDGGDKLGAKRSQMVSYRNFTKKLMPPKPITTPSSHFVMKLLNEVEKQRSFSPVPLMGSKSFEEHHRVQFFFIEFQLRPLSERGLLLYFGTLNNNQDKKIGFVSLSLQGGVVEFRISGPSNHVTVVRSVRMLAIGEWHKIKMAQRGRWLTLWVEGSASSALAPSAEVLVEPDSLLYIGGLKDVSKLPHNAISGFPIPFRGCVRGLVVSGTRIVLNETNIVESRNIRDCDGTACGGDSCESGGHCWLDEKLQPHCICPEYAKGDRCEYSETCKLIPCKNNGRCLRSGRCSCPNGWGGFYCEIAMSKPTTPSFRGNSYLILPPPRIPMKDKRRGPSLYVRPREAIQVSLNFSTIEPDGLLLWSEHERSKFLGLGLEAGHLKLASNLLGSTNDTVRAPASGFIADGAWHWTSVLLDRSRLELQLDGEVIFTERLPEGGRSLGSTTPRSTLAGRRKNSSKEPTISYEDVFYLGGFPNSDSVSRRTKGRFFDPFKGCLQDIQFGAEPTAIISDFSTYQGENIGSCDLHGDEPLTV", "length": 2176, "header": "sp|A0A1F4-1|EYS_DROME Isoform 1 of Protein eyes shut OS=Drosophila melanogaster OX=7227 GN=eys PE=1 SV=1 CANONICAL=A0A1F4-1" }, "isoforms": [ { "isoform_ac": "A0A1F4-1", "url": "https://www.uniprot.org/uniprotkb/A0A1F4/entry#A0A1F4-1", "sequence": { "sequence": "MSNVHQFDTQTMAESPQIRRDMGRLCATWPSKDSEDGAGTALRAATPLTANGATTTGLSVTLAPKDMQRNHLLKMPTATIEKPTITATIASSSSTSTSTTRKSVTATRSLKLNPNILLPTLRILARGLLLPALILAILVGSSQAGFACLSNPCVFGVCIDGLNSSYSCYCIDGYTGIQCQTNWDECWSSPCQNGGTCVDGVAYYNCTCPEGFSGSNCEENVDECMSNPCQNGGLCRDRTNGYICTCQPGYLGSHCELDVAVCETGTGARCQHGGECIEGPGLEFTCDCPAGWHGRICQEEINECASSPCQNGGVCVDKLAAYACACPMGYTGINCEEEILICADNPCQNNALCLMEEGVPTCYCVPDYHGEKCEFQYDECQLGPRCMNGGVCIDGVDTFSCSCPPLLTGMLCECLMVGEESLDCNYTAPATQSPPRRTTTTSTMAPPTVRPVTPPETTVSPSRASEEVEIIVVTTSAPAEVVTSVLSPSSSSSSSEEGVSVEIKTPTVAPPESGSHSISVEQTTAVPAQPEPESEQEPESKPHPESESASESETETEEEIIPGTTARPPTSRSSSSSEESPSIFTTLPPLPGKPQTSASSESSGEVVTSEEYTTVPHFEVSGSKSESGSEEVTTVRPTAAPSITISVDITSSGSSSSSSESVEVFTTPAPVFVQRVTTIETSISIDYVTPTPLPETTTPRVVPVPRPTFAPEPPLDVVETTASTHHLWTEVPTTAAPFFTEYPAEVLITTHRTSAGRFTTVQPPAGVTTTSPTEDSSVELPTPHTPQIVVTILDSNEVIPSLITTTGSPTTHHHHHHHPHHEAEGTTLQPLEEDEHHHHHHHDEFTTPQPVEITTGHPLQTEDLIGVQEPAVVTTESPFAPAETTVVPVVVPATIAPLGTAAPPATPAPVPPATTTPPPSPPSLATETPTLPPTLPPVTLPPVTQPPPTIPPTPPSTQSAQTLPPPTSAINVYTTPDGPPTASQTKPSVTESSEEVEGTNTVSTGGRGSGGVPEEKAGDVDCIKLGCYNGGTCVTTSEGSRCVCRFDRQGPLCELPIIIRNAAFSGDSYVSHRIYKDIGGHESLDAVLPMHIQLKVRTRATNGLIMLAAAQGTKGGHYMALFLQKGLMQFQFSCGLQTMLLSELETPVNTGHEITIRAELDFSRNYTHCNASLLVNDTLAMSGDQPTWLKLLPPRLHTPEAILNTWLHLGGAPQAPIGLIIELPPAQSGSGFTGCLHTLRINGQAREIFGDALDGFGITECGSLACLSSPCRNGAACIKIETNDLDENGEKAEKWKCKCPTGYMGPTCEISVCEDNPCQYGGTCVQFPGSGYLCLCPLGKHGHYCEHNLEVALPSFSGSVNGLSSFVAYTVPIPLEYSLELSFKILPQTMSQISLLAFFGQSGYHDEKSDHLAVSFIQGYIMLTWNLGAGPRRIFTQKPIDFRLDAPRVPYEIKVGRIGRQAWLSVDGKFNITGRSPGSGSRMDVLPILYLGGHEIANFNTLPHDLPLHSGFQGCIYDVQLKAGQVTVPLQETRGVRGRGVGQCGTRECHRHACQHDGACLQHGATFTCICQEGWYGPLCAQPTNPCDSFNNKCYEDATCVPLVNGYECDCPVGRTGKNCEEVIRSLSDVSLTGRRSYLAVRWPYLYDGGDKLGAKRSQMVSYRNFTKKLMPPKPITTPSSHFVMKLLNEVEKQRSFSPVPLMGSKSFEEHHRVQFFFIEFQLRPLSERGLLLYFGTLNNNQDKKIGFVSLSLQGGVVEFRISGPSNHVTVVRSVRMLAIGEWHKIKMAQRGRWLTLWVEGSASSALAPSAEVLVEPDSLLYIGGLKDVSKLPHNAISGFPIPFRGCVRGLVVSGTRIVLNETNIVESRNIRDCDGTACGGDSCESGGHCWLDEKLQPHCICPEYAKGDRCEYSETCKLIPCKNNGRCLRSGRCSCPNGWGGFYCEIAMSKPTTPSFRGNSYLILPPPRIPMKDKRRGPSLYVRPREAIQVSLNFSTIEPDGLLLWSEHERSKFLGLGLEAGHLKLASNLLGSTNDTVRAPASGFIADGAWHWTSVLLDRSRLELQLDGEVIFTERLPEGGRSLGSTTPRSTLAGRRKNSSKEPTISYEDVFYLGGFPNSDSVSRRTKGRFFDPFKGCLQDIQFGAEPTAIISDFSTYQGENIGSCDLHGDEPLTV", "length": 2176, "header": "sp|A0A1F4-1|EYS_DROME Isoform 1 of Protein eyes shut OS=Drosophila melanogaster OX=7227 GN=eys PE=1 SV=1 CANONICAL=A0A1F4-1" }, "locus": { "chromosome": "2L", "start_pos": 2357874, "end_pos": 2323766, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0344662", "url": "https://www.ensemblgenomes.org/id/FBtr0344662" }, { "database": "Ensembl Peptide", "id": "FBpp0311004", "url": "https://www.ensemblgenomes.org/id/FBpp0311004" } ] } }, { "isoform_ac": "M9PBU9-1", "url": "https://www.uniprot.org/uniprotkb/A0A1F4/entry#M9PBU9-1", "sequence": { "sequence": "MSNVHQFDTQTMAESPQIRRDMGRLCATWPSKDSEDGAGTALRAATPLTANGATTTGLSVTLAPKDMQRNHLLKMPTATIEKPTITATIASSSSTSTSTTRKSVTATRSLKLNPNILLPTLRILARGLLLPALILAILVGSSQAGFACLSNPCVFGVCIDGLNSSYSCYCIDGYTGIQCQTNWDECWSSPCQNGGTCVDGVAYYNCTCPEGFSGSNCEENVDECMSNPCQNGGLCRDRTNGYICTCQPGYLGSHCELDVAVCETGTGARCQHGGECIEGPGLEFTCDCPAGWHGRICQEEINECASSPCQNGGVCVDKLAAYACACPMGYTGINCEEEILICADNPCQNNALCLMEEGVPTCYCVPDYHGEKCEFQYDECQLGPRCMNGGVCIDGVDTFSCSCPPLLTGMLCECLMVGEESLDCNYTAPATQSPPRRTTTTSTMAPPTVRPVTPPETTVSPSRASEEVEIIVVTTSAPAEVVTSVLSPSSSSSSSEEGVSVEIKTPTVAPPESGSHSISVEQTTAVPAQPEPESEQEPESKPHPESESASESETETEEEIIPGTTARPPTSRSSSSSEESPSIFTTLPPLPGKPQTSASSESSGEVVTSEEYTTVPHFEVSGSKSESGSEEVTTVRPTAAPSITISVDITSSGSSSSSSESVEVFTTPAPVFVQRVTTIETSISIDYVTPTPLPETTTPRVVPVPRPTFAPEPPLDVVETTASTHHLWTEVPTTAAPFFTEYPAEVLITTHRTSAGRFTTVQPPAGVTTTSPTEDSSVELPTPHTPQIVVTILDSNEVIPSLITTTGSPTTHHHHHHHPHHEAEGTTLQPLEEDEHHHHHHHDEFTTPQPVEITTGHPLQTEDLIGVQEPAVVTTESPFAPAETTVVPVVVPATIAPLGTAAPPATPAPVPPATTTPPPSPPSLATETPTLPPTLPPVTLPPVTQPPPTIPPTPPSTQSAQTLPPPTSAINVYTTPDGPPTASQTKPSVTESSEEVEGTNTVSTGGRGSGGVPEEKAGDVDCIKLGCYNGGTCVTTSEGSRCVCRFDRQGPLCELPIIIRNAAFSGDSYVSHRIYKDIGGHESLDAVLPMHIQLKVRTRATNGLIMLAAAQGTKGGHYMALFLQKGLMQFQFSCGLQTMLLSELETPVNTGHEITIRAELDFSRNYTHCNASLLVNDTLAMSGDQPTWLKLLPPRLHTPEAILNTWLHLGGAPQAPIGLIIELPPAQSGSGFTGCLHTLRINGQAREIFGDALDGFGITECGSLACLSSPCRNGAACIKIETNDLDENGEKAEKWKCKCPTGYMGPTCEISVCEDNPCQYGGTCVQFPGSGYLCLCPLGKHGHYCEHNLEVALPSFSGSVNGLSSFVAYTVPIPLEYSLELSFKILPQTMSQISLLAFFGQSGYHDEKSDHLAVSFIQGYIMLTWNLGAGPRRIFTQKPIDFRLDAPRVPYEIKVGRIGRQAWLSVDGKFNITGRSPGSGSRMDVLPILYLGGHEIANFNTLPHDLPLHSGFQGCIYDVQLKAGQVTVPLQETRGVRGRGVGQCGTRECHRHACQHDGACLQHGATFTCICQEGWYGPLCAQPTNPCDSFNNKCYEDATCVPLVNGYECDCPVGRTGKNCEEVIRSLSDVSLTGRRSYLAVRWPYLYDGGDKLGAKRSQMVSYRNFTKKLMPPKPITTPSSHFVMKLLNEVEKQRSFSPVPLMGSKSFEEHHRVQFFFIEFQLRPLSERGLLLYFGTLNNNQDKKIGFVSLSLQGGVVEFRISGPSNHVTVVRSVRMLAIGEWHKIKMAQRGRWLTLWVEGSASSALAPSAEVLVEPDSLLYIGGLKDVSKLPHNAISGFPIPFRGCVRGLVVSGTRIVLNETNIVESRNIRDCDGTACGGDSCESGGHCWLDEKLQPHCICPEYAKGDRCEYSETCKLIPCKNNGRCLRSGRCSCPNGWGGFYCEIAMSKPTTPSFRGNSYLILPPPRIPMKDKRRGPSLYVRPREAIQVSLNFSTIEPDGLLLWSEHERSKFLGLGLEAGHLKLASNLLGSTNDTVRAPASGFIADGAWHWTSVLLDRSRLELQLDGEVIFTERLPEGGRSLGSTTPRSTLAGRRKNSSKEPTISYEDVFYLGGFPNSDSVSRRTKGRFFDPFKGCLQDIQFGAEPTAIISDFSTYQGENIGSCDLHGDEPLTV", "length": 2176, "header": "tr|M9PBU9-1|EYS_DROME Computationally mapped isoform of Protein eyes shut OS=Drosophila melanogaster OX=7227 GN=eys PE=1 SV=2 CANONICAL=A0A1F4-1" }, "locus": { "chromosome": "2L", "start_pos": 2357874, "end_pos": 2323766, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0344662", "url": "https://www.ensemblgenomes.org/id/FBtr0344662" }, { "database": "Ensembl Peptide", "id": "FBpp0311004", "url": "https://www.ensemblgenomes.org/id/FBpp0311004" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool": "", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1165, "start_aa": "Asn", "end_pos": 1165, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1165", "evidence": [ { "id": "A0A1F4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1F4#ptm_processing" } ], "filter_code": "00100000000000000000.00010000000000.0.01000" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool": "", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1170, "start_aa": "Asn", "end_pos": 1170, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1170", "evidence": [ { "id": "A0A1F4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1F4#ptm_processing" } ], "filter_code": "00100000000000000000.00010000000000.0.01000" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool": "", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1176, "start_aa": "Asn", "end_pos": 1176, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1176", "evidence": [ { "id": "A0A1F4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1F4#ptm_processing" } ], "filter_code": "00100000000000000000.00010000000000.0.01000" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool": "", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1471, "start_aa": "Asn", "end_pos": 1471, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1471", "evidence": [ { "id": "A0A1F4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1F4#ptm_processing" }, { "id": "17893096", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/17893096" } ], "filter_code": "00100000000000000000.00010000000000.0.01000" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool": "", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 163, "start_aa": "Asn", "end_pos": 163, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn163", "evidence": [ { "id": "A0A1F4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1F4#ptm_processing" } ], "filter_code": "00100000000000000000.00010000000000.0.01000" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool": "", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1665, "start_aa": "Asn", "end_pos": 1665, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1665", "evidence": [ { "id": "A0A1F4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1F4#ptm_processing" } ], "filter_code": "00100000000000000000.00010000000000.0.01000" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool": "", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1861, "start_aa": "Asn", "end_pos": 1861, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1861", "evidence": [ { "id": "A0A1F4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1F4#ptm_processing" } ], "filter_code": "00100000000000000000.00010000000000.0.01000" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool": "", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1994, "start_aa": "Asn", "end_pos": 1994, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1994", "evidence": [ { "id": "A0A1F4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1F4#ptm_processing" } ], "filter_code": "00100000000000000000.00010000000000.0.01000" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool": "", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 2035, "start_aa": "Asn", "end_pos": 2035, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn2035", "evidence": [ { "id": "A0A1F4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1F4#ptm_processing" } ], "filter_code": "00100000000000000000.00010000000000.0.01000" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool": "", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 205, "start_aa": "Asn", "end_pos": 205, "end_aa": "Asn", 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(GlcNAc...) asparagine", "start_pos": 425, "start_aa": "Asn", "end_pos": 425, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn425", "evidence": [ { "id": "A0A1F4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1F4#ptm_processing" } ], "filter_code": "00100000000000000000.00010000000000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool": "isoglyp", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 453, "start_aa": "T", "end_pos": 453, "end_aa": "T", "residue": "Thr", "site_lbl": "Thr453", "evidence": [ { "id": "GLY_001163", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001163" } ], "filter_code": "00000000000000001000.00000000001000.1.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool": "isoglyp", "site_category": "predicted", "site_category_dict": { "predicted": true }, 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