{ "uniprot_canonical_ac": "A0A1D5PWN4-1", "uniprot_ac": "A0A1D5PWN4", "uniprot_id": "A0A1D5PWN4_CHICK", "mass": { "chemical_mass": 55230.0, "monoisotopic_mass": 55230.0 }, "refseq": {}, "gene_names": [ { "name": "ATG4C", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A1D5PWN4", "id": "A0A1D5PWN4" } ], "protein_names": [ { "name": "Cysteine protease", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PWN4/entry#names_and_taxonomy", "id": "A0A1D5PWN4" }, { "name": "3.4.22.-", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PWN4/entry#names_and_taxonomy", "id": "A0A1D5PWN4" } ], "function": [ { "annotation": "Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.", "evidence": [ { "database": "UniProtKB", "id": "A0A8V1A079", "url": "https://www.uniprot.org/uniprot/A0A8V1A079#function" }, { "database": "UniProtKB", "id": "RU363115", "url": "https://www.uniprot.org/uniprot/RU363115#function" }, { "database": "UniProtKB", "id": "A0A1D5PWN4", "url": "https://www.uniprot.org/uniprot/A0A1D5PWN4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Gallus gallus", "taxid": 9031, "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PWN4", "url": "https://www.uniprot.org/uniprot/A0A1D5PWN4" } ], "common_name": "Chicken", "glygen_name": "Chicken", "reference_species": "Gallus gallus [9031]" } ], "gene": [ { "name": "ATG4C", "url": "https://www.uniprot.org/uniprot/A0A1D5PWN4", "locus": { "chromosome": "8", "start_pos": 27304071, "end_pos": 27282096, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSGALG00010024179", "url": "https://www.ensembl.org/id/ENSGALG00010024179" } ] } } ], "crossref": [ { "id": "A0A1D5PWN4", "url": "https://alphafold.ebi.ac.uk/entry/A0A1D5PWN4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSGALG00000010985", "url": "https://bgee.org/?page=gene&gene_id=ENSGALG00000010985", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR005078", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005078", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046792", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046792", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "KMAGDWY", "url": "https://omabrowser.org/oma/group/KMAGDWY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A1D5PWN4", "url": "https://www.orthodb.org/?gene=A0A1D5PWN4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22624", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22624", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22624:SF38", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22624:SF38", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03416", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03416", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-GGA-1632852", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-1632852", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "67548", "url": "https://www.rhea-db.org/rhea/67548", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A1D5PWN4", "url": "https://www.uniprot.org/uniprot/A0A1D5PWN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1D5PWN4-1", "url": "https://www.uniprot.org/uniprot/A0A1D5PWN4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V1A079", "url": "https://www.uniprot.org/uniprot/A0A8V1A079", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V1A079-1", "url": "https://www.uniprot.org/uniprot/A0A8V1A079-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEATGTDEVEKIKSKFMSAWNNMKYSWVLKTKTYFSRNSPVFLLGKCYHFKSDESGELSTEGSNFDKINTEISGNVEEFRKDFISRIWLTYREEFPQIKGSALTTDCGWGCTLRTGQMLLAQGLMLHFLGRAWVWPDALDIENSDSESWTAHTVKKLTASLEASLTAEREPKILSHHQERTLRRDCGDSEMRNEVYHRKIISWFGDSPLAAFGLHQLIEYGKKSGKIAGDWYGPAVVAHILRKAVEEARDPELQGVTVYVAQDCTVYSSDVIDRQCSFMDSGETDTKAVIILVPVRLGGERTNMDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDFPLESFHCPSPKKMSFKKMDPSCTIGFYCRTVQDFEKASEEITKVSPSKSVPSRPSTWKAQVEVYLGPKMLKSSSKEKYPLFTFVKGHSRDYDFASSPLHEENDLFSEDEKKRLKRFSTEEFVLL", "length": 484, "header": "tr|A0A1D5PWN4-1|A0A1D5PWN4_CHICK Isoform 1 of Cysteine protease OS=Gallus gallus OX=9031 GN=ATG4C PE=3 SV=1 CANONICAL=A0A1D5PWN4-1" }, "isoforms": [ { "isoform_ac": "A0A1D5PWN4-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PWN4/entry#A0A1D5PWN4-1", "sequence": { "sequence": "MEATGTDEVEKIKSKFMSAWNNMKYSWVLKTKTYFSRNSPVFLLGKCYHFKSDESGELSTEGSNFDKINTEISGNVEEFRKDFISRIWLTYREEFPQIKGSALTTDCGWGCTLRTGQMLLAQGLMLHFLGRAWVWPDALDIENSDSESWTAHTVKKLTASLEASLTAEREPKILSHHQERTLRRDCGDSEMRNEVYHRKIISWFGDSPLAAFGLHQLIEYGKKSGKIAGDWYGPAVVAHILRKAVEEARDPELQGVTVYVAQDCTVYSSDVIDRQCSFMDSGETDTKAVIILVPVRLGGERTNMDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDFPLESFHCPSPKKMSFKKMDPSCTIGFYCRTVQDFEKASEEITKVSPSKSVPSRPSTWKAQVEVYLGPKMLKSSSKEKYPLFTFVKGHSRDYDFASSPLHEENDLFSEDEKKRLKRFSTEEFVLL", "length": 484, "header": "tr|A0A1D5PWN4-1|A0A1D5PWN4_CHICK Isoform 1 of Cysteine protease OS=Gallus gallus OX=9031 GN=ATG4C PE=3 SV=1 CANONICAL=A0A1D5PWN4-1" }, "locus": { "chromosome": "8", "start_pos": 27303019, "end_pos": 27284329, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010058981.1", "url": "https://www.ensembl.org/id/ENSGALT00010058981.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010035946.1", "url": "https://www.ensembl.org/id/ENSGALP00010035946.1" } ] } }, { "isoform_ac": "A0A8V1A079-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PWN4/entry#A0A8V1A079-1", "sequence": { "sequence": "MEATGTDEVEKIKSKFMSAWNNMKYSWVLKTKTYFSRNSPVFLLGKCYHFKSDESGELSTEGSNFDKINTEISGNVEEFRKDFISRIWLTYREEFPQIKGSALTTDCGWGCTLRTGQMLLAQGLMLHFLGRAWVWPDALDIENSDSESWTAHTVKKLTASLEASLTAEREPKILSHHQERTLRRDCGDSEMRNEVYHRKIISWFGDSPLAAFGLHQLIEYGKKSGKIAGDWYGPAVVAHILSFVFVLRKAVEEARDPELQGVTVYVAQDCTVYSSDVIDRQCSFMDSGETDTKAVIILVPVRLGGERTNMDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDFPLESFHCPSPKKMSFKKMDPSCTIGFYCRTVQDFEKASEEITKMLKSSSKEKYPLFTFVKGHSRDYDFASSPLHEENDLFSEDEKKRLKRFSTEEFVLL", "length": 465, "header": "tr|A0A8V1A079-1|A0A1D5PWN4_CHICK Computationally mapped isoform of Cysteine protease OS=Gallus gallus OX=9031 GN=ATG4C PE=3 SV=1 CANONICAL=A0A1D5PWN4-1" }, "locus": { "chromosome": "8", "start_pos": 27303019, "end_pos": 27284329, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010058977.1", "url": "https://www.ensembl.org/id/ENSGALT00010058977.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010035942.1", "url": "https://www.ensembl.org/id/ENSGALP00010035942.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-GGA-1632852", "name": "Macroautophagy", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-1632852", "resource": "Reactome", "description": "Macroautophagy" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZXZ8-1", "protein_name": "Cysteine protease", "gene_name": "Atg4c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEASGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDESKVLPARSGCAIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEASALTTDCGWGCTLRTGQMLLAQGLILHFLGRAWTWPDALHIESSDSDSWTSNTIHKFTASFEASLSGERELRTPAVSLKETSGKHPDDHAVQSEIYHRQIISWFGDSPVAVFGLHRLIEFGKKSGKKAGDWYGPAVVAHILRKAVEEARHPDLQGLTIYVAQDCTVYNSDVIDKQTDSVTAGDARDKAVIILVPVRLGGERTNIDYLEFVKGVLSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDFPLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFERASEEITKMLKISSKEKYPLFTFVNGHSRDFDFTSTAASEEDLFLEDEKKNFKRFSTEEFVLL", "length": 458 }, "evidence": [ { "id": "A0A1D5PWN4", "url": "https://omabrowser.org/oma/group/A0A1D5PWN4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1MJ23-1", "protein_name": "Cysteine protease", "gene_name": "ATG4C", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MEATGTDDVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDENELLPARSGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLLAQGLILHFLGRAWTWPDALNIENSDSESWTSNTVKKFTASFEASLSGERELKTPTISLKEKMERYSDDREMQNEIYHRKIISWFGDSPLALFGLHQLIAYGKKSGKKAGDWYGPAVVAHILRKAVEEARHPDLKGITIYVAQDCTVYSSDVIDKQCTSMASDNTNDKAVIILVPVRLGGERTNADYLDFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDFPLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKISSKEKYPLFTFVNGHSRDYDFTSTTTNEEDLFSEDEKKRIKRFSTEEFVLL", "length": 458 }, "evidence": [ { "id": "A0A1D5PWN4", "url": "https://omabrowser.org/oma/group/A0A1D5PWN4/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "F1S810-1", "protein_name": "Cysteine protease", "gene_name": "ATG4C", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEATGTDEVDKLKTKFVSAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKLLPARSGCTIKDHVIAGNVEEFRKDFISRIWLTYREEFPQLEGSALTTDCGWGCTLRTGQMLLAQGLVLHFLGRAWTWPDALNIENSDSESWTSNTVKKFTASFEASLSGERELKTPTISLKETIGRYSDDREKQNEIYHRKIISWFGDSPLTLFGLHQLIECGKKSGKKAGDWYGPAVVAHILRKAVEEARHPDLQGITIYVAQDCTVYSSDVIDKQCASMAPDNTDDKAVIILVPVRLGGERTNADYLDFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDFPLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKSSSKEKYPLFTFVNAHSRDYDFTSTTTNKEDLFSEDEKKRLNRFSTEEFVLL", "length": 458 }, "evidence": [ { "id": "A0A1D5PWN4", "url": "https://omabrowser.org/oma/group/A0A1D5PWN4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q811C2-1", "protein_name": "Cysteine protease ATG4C", "gene_name": "Atg4c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEASGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDESKMLPARSGCAIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEASALTTDCGWGCTLRTGQMLLAQGLILHFLGRAWTWPDALHIENADSDSWTSNTVKKFTASFEASLSGDRELRTPAVSLKETSGKCPDDHAVRNEAYHRKIISWFGDSPVAVFGLHRLIEFGKKSGKKAGDWYGPAVVAHILRKAVEEARHPDLQGLTIYVAQDCTVYNSDVIDKQTDSVTAGDARDKAVIILVPVRLGGERTNTDYLEFVKGVLSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDFPLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFERASEEITKMLKISSKEKYPLFTFVNGHSKDFDFTSTAASEEDLFSEDERKNFKRFSTEEFVLL", "length": 458 }, "evidence": [ { "id": "A0A1D5PWN4", "url": "https://omabrowser.org/oma/group/A0A1D5PWN4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96DT6-1", "protein_name": "Cysteine protease ATG4C", "gene_name": "ATG4C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLPAESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLLAQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKETIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHILRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGERTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDFPLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVNGHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL", "length": 458 }, "evidence": [ { "id": "A0A1D5PWN4", "url": "https://omabrowser.org/oma/group/A0A1D5PWN4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PWN4", "url": "https://www.uniprot.org/uniprot/A0A1D5PWN4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PWN4", "url": "https://www.uniprot.org/uniprot/A0A1D5PWN4" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PWN4", "url": "https://www.uniprot.org/uniprot/A0A1D5PWN4" } ], "pmid": "" }, { "name": "autophagy", "id": "GO:0006914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PWN4", "url": "https://www.uniprot.org/uniprot/A0A1D5PWN4" } ], "pmid": "" }, { "name": "autophagosome assembly", "id": "GO:0000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000045", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PWN4", "url": "https://www.uniprot.org/uniprot/A0A1D5PWN4" } ], "pmid": "" }, { "name": "protein processing", "id": "GO:0016485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016485", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PWN4", "url": "https://www.uniprot.org/uniprot/A0A1D5PWN4" } ], "pmid": "" }, { "name": "mitophagy", "id": "GO:0000423", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000423", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PWN4", "url": "https://www.uniprot.org/uniprot/A0A1D5PWN4" } ], "pmid": "" }, { "name": "piecemeal microautophagy of the nucleus", "id": "GO:0034727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034727", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PWN4", "url": "https://www.uniprot.org/uniprot/A0A1D5PWN4" } ], "pmid": "" }, { "name": "aggrephagy", "id": "GO:0035973", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035973", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PWN4", "url": "https://www.uniprot.org/uniprot/A0A1D5PWN4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "cysteine-type peptidase activity", "id": "GO:0008234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008234", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PWN4", "url": "https://www.uniprot.org/uniprot/A0A1D5PWN4" } ], "pmid": "" }, { "name": "protein-phosphatidylethanolamide deconjugating activity", "id": "GO:0019786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019786", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PWN4", "url": "https://www.uniprot.org/uniprot/A0A1D5PWN4" } ], "pmid": "" }, { "name": "cysteine-type endopeptidase activity", "id": "GO:0004197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004197", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PWN4", "url": "https://www.uniprot.org/uniprot/A0A1D5PWN4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "67548", "name": "", "equation": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A8V1A343-1", "A0A1D5PWN4-1", "A0A1I7Q405-1", "Q5ZIW7-1", "Q6PZ02-1" ], "evidence": [ { "id": "67548", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67548" } ] }, { "id": "R-GGA-5681987", "name": "LC3 is cleaved by ATG4", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A1D5PWN4-1", "A0A1I7Q405-1", "Q6PZ02-1" ], "evidence": [ { "id": "R-GGA-5681987", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-5681987" } ] }, { "id": "R-GGA-5682377", "name": "LC3 de-lipidation by ATG4", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, phagophore assembly site membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A1D5PWN4-1", "A0A1I7Q405-1", "Q6PZ02-1" ], "evidence": [ { "id": "R-GGA-5682377", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-5682377" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A1D5PWN4", "gene_name": "ATG4C", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "A0A1D5PWN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1D5PWN4" } ] } ] }, { "uniprot_ac": "A0A1I7Q405", "gene_name": "ATG4A", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "A0A1I7Q405", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1I7Q405" } ] } ] }, { "uniprot_ac": "A0A8V1A343", "gene_name": "ATG4B", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "A0A8V1A343", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V1A343" } ] } ] }, { "uniprot_ac": "Q5ZIW7", "gene_name": "ATG4A", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "Q5ZIW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5ZIW7" } ] } ] }, { "uniprot_ac": "Q6PZ02", "gene_name": "ATG4B", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "Q6PZ02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PZ02" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A1D5PWN4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 484, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A1D5PWN4-F1.pdb" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }