{ "uniprot_canonical_ac": "A0A1D5PRR9-1", "uniprot_ac": "A0A1D5PRR9", "uniprot_id": "FANCM_CHICK", "mass": { "chemical_mass": 224006.0, "monoisotopic_mass": 224006.0 }, "refseq": {}, "gene_names": [ { "name": "FANCM", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A1D5PRR9", "id": "A0A1D5PRR9" } ], "protein_names": [ { "name": "Fanconi anemia group M protein", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PRR9/entry#names_and_taxonomy", "id": "A0A1D5PRR9" }, { "name": "3.6.4.13", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PRR9/entry#names_and_taxonomy", "id": "A0A1D5PRR9" }, { "name": "ATP-dependent RNA helicase FANCM", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PRR9/entry#names_and_taxonomy", "id": "A0A1D5PRR9" }, { "name": "FAAP250", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PRR9/entry#names_and_taxonomy", "id": "A0A1D5PRR9" }, { "name": "Fanconi anemia-associated polypeptide of 250 kDa", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PRR9/entry#names_and_taxonomy", "id": "A0A1D5PRR9" }, { "name": "Protein FACM", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PRR9/entry#names_and_taxonomy", "id": "A0A1D5PRR9" }, { "name": "Protein Hef ortholog", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PRR9/entry#names_and_taxonomy", "id": "A0A1D5PRR9" } ], "function": [ { "annotation": "DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116434, PubMed:19465393). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork (By similarity). This activity is strongly stimulated in the presence of CENPS and CENPX (By similarity). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (By similarity). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PRR9", "url": "https://www.uniprot.org/uniprot/A0A1D5PRR9#function" }, { "database": "PubMed", "id": "16116434", "url": "https://glygen.org/publication/PubMed/16116434" }, { "database": "PubMed", "id": "19465393", "url": "https://glygen.org/publication/PubMed/19465393" }, { "database": "UniProtKB", "id": "Q8IYD8", "url": "https://www.uniprot.org/uniprot/Q8IYD8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 207, "end_pos": 207, "sequence_org": "D", "sequence_mut": "A", "comment": "Increased sister chromatid exchanges. No effect on FANCD2 monoubiquitination, nor on cisplatin sensitivity.", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PRR9", "url": "https://www.uniprot.org/uniprot/A0A1D5PRR9" }, { "database": "PubMed", "id": "16116434", "url": "https://glygen.org/publication/PubMed/16116434" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Gallus gallus", "taxid": 9031, "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PRR9", "url": "https://www.uniprot.org/uniprot/A0A1D5PRR9" } ], "common_name": "Chicken", "glygen_name": "Chicken", "reference_species": "Gallus gallus [9031]" } ], "gene": [ { "name": "FANCM", "url": "https://www.uniprot.org/uniprot/A0A1D5PRR9", "locus": { "chromosome": "5", "start_pos": 58498352, "end_pos": 58557868, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSGALG00010018216", "url": "https://www.ensembl.org/id/ENSGALG00010018216" } ] } } ], "crossref": [ { "id": "A0A1D5PRR9", "url": "https://alphafold.ebi.ac.uk/entry/A0A1D5PRR9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd12091", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12091", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18033", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18033", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18801", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18801", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20077", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20077", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006166", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006166", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010994", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010994", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011335", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011335", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011545", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011545", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039686", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039686", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044749", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044749", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047418", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047418", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "gga:100857997", "url": "https://www.genome.jp/dbget-bin/www_bget?gga:100857997", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR14025", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14025", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14025:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14025:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "7DA2", "url": "https://www.rcsb.org/structure/7DA2", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00270", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00270", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00271", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02732", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02732", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16783", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16783", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_A0A1D5PRR9", "url": "http://purl.obolibrary.org/obo/PR_A0A1D5PRR9", "database": "PRO", "categories": [ "Protein" ] }, { "id": "XP_015132266", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015132266", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A1D5PRR9", "url": "https://www.uniprot.org/uniprot/A0A1D5PRR9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1D5PRR9-1", "url": "https://www.uniprot.org/uniprot/A0A1D5PRR9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGGRQRTLPEAWRRAAGPALQAGRDADGNDDDDDELLAAAAAELDPDPNPNVDPNPGPGPEAAAGGFCAAAGALWIYPTNRPERPYQLRMARAALFANTLLCLPTGLGKTFVAAVVMYNFYRWFPSGKVLFLAPTKALVAQQMEACAQLMGIPGRDMAEMTGGTQALSRRELWASRRVFFLTPQIMVNDLSRGTCPAVEVKCLVVDEAHKALGNHAYCQVVKELSRYTTQFRVLALTATPGSDTKAVQQVVSNLLIAQIELCSEDSPEIQPYSHERQVEKIVVPLGEELGGIQRAYIHVLETFAGRLIKLGVLARRDVPSLTKYQIILARDQYRKNPSPQNVGMQPGIIEGDFALCISLYHGYELLQQMGVRSLFIYLCGIMDGSKGLTRTKNELGRNEDFMRLYQQLTDMFSDTCQTSANGNLHKSRTVSENKKEFIYSHPKLKKLEEIVIEHFKSRKMGCSDQTTSGGTCVDTRVMIFSSFRDSVQEIAEMLSRFSPVVRVMTFVGHSTGKSTKGFTQKEQLEVVKRFREGGYNTLVSTCVGEEGLDIGEVDLIICFDAQKSPIRLVQRMGRTGRQRQGRVVVILAEGREERTYNQSQSNRRSIQKAISGNKMLHFYQHSPRMIPEGINPELHRMFITAEKYKPNDSGRLPKGRPSSLHHKSALFSCVTDPKEMHCHENWSLSPEEFEIWDRLYRLKENDGVKEPILPHTRFETLENLDKTSKPEEEAAHKLSLSEWSIWQSRPFPTSMVDHSDRCYHFISVMELIEVMRQEQGDCSYELELQPHLRIEDIHVRRNKGHLSTTSSAFAQKTHSSKRDMARTKRPFVPDVNDNEREFFSIFKTTNTKTPRTAPGLDLEEPELPTDTNGSEPCSARRLTLVASTDQGSPKEEEIEKVTFDLNEFNDLCDDGESTVAHESAAVKDLRLLDKHCSSVGLNHTDLGYSSFTAEKSPASSDLFYLPESHVDSFVLVSSSAELAGLEGAFSCVKGLLAHSPPPVSKLEGIEELLRHEETLCPLPKVSCRSYSGQLPHGDFPSSLAVDQSLLPAESPELEVTIGLSAAVNTCVSKPASTPTAAGGAEERPPGGGSFHSLLGKEGFTANHTDNPPNKHFVQGDEEDSEMKRDVTIDGEKSIHLFEDEHTYKVNDEMPSVDVEPLLRLGSGGHTARPSAGPASQQPPSGDSPRGDTACGEGAARGEMAPGGAWGRGSAAEQALHNSELCDYSQELFSVNFDLGFSIEECEEEIFEGDTDAMNTPKLNSASRSRADVQLTANRKSLNDGCRVQTPPKWDCKGLKGRNISTPLPLQSGHVRDTAVPGGTAGGRTGRGSPGASPPSPATPTGRRVSSAEATRRIRKKVFSTVREETPEVCPTDKVNPNSQRNSFGSSASDALHTTGGRTENLEGTNLHTSRVFPAEGTSSESEEEIVFQRKNRRNNVLRSPDVGSDSDFGSPVCAVRKRRHPLTVSDVSSDDGVDFHKNPNRGTRGCSAAGSKAQLRGVKRQKVRSKVTCKNAARQFLDEEAELSQQDESCVSSDETEDTDKELSSSLAQFLNDDAEVTQVLNDSEMRGVYLKSVRSPALGSRYRMVHREFNSTEIFSQIPEQDEAYAEDSFCVAEGDEETCNKSESSEEEEVCVNFDLLNNESFGGGGGRYLTRRRKKLHGANMEQNCSAPVQKKPSRIIVLSDSSGEETNVSNEKGTAAHCSRAGRENAELLTSMPSVSSVPHKKSAGDVSAHQSAESKSGMLLGLKASVSEVLDFHPGPRSGSGKEALQAAAQHLQLESSVKNSAGNAPGATKASPALLDGDTALCVLVDSREISSGADVISSLKAVHGLKVQVCSLGSGDYVVSNRMAVERKFQSELLSSVNRTKVTQRLQRLQGMFERVCVIVEKDRTRPGETSRFSQRTQHYDATLAALLQAGIRVLFSSCQEETAVLLKELALLEQRKNAAICVPTEVEGHKQEMLNFYLSLPNISYLAALNMCHHFSSVRTMVNSSPSDIAAGARVSLQRAEETYRYLRYGFDTQMLPESLCAKGKSNTATRS", "length": 2041, "header": "sp|A0A1D5PRR9-1|FANCM_CHICK Isoform 1 of Fanconi anemia group M protein OS=Gallus gallus OX=9031 GN=FANCM PE=1 SV=1 CANONICAL=A0A1D5PRR9-1" }, "isoforms": [ { "isoform_ac": "A0A1D5PRR9-1", "url": "https://www.uniprot.org/uniprotkb/A0A1D5PRR9/entry#A0A1D5PRR9-1", "sequence": { "sequence": "MSGGRQRTLPEAWRRAAGPALQAGRDADGNDDDDDELLAAAAAELDPDPNPNVDPNPGPGPEAAAGGFCAAAGALWIYPTNRPERPYQLRMARAALFANTLLCLPTGLGKTFVAAVVMYNFYRWFPSGKVLFLAPTKALVAQQMEACAQLMGIPGRDMAEMTGGTQALSRRELWASRRVFFLTPQIMVNDLSRGTCPAVEVKCLVVDEAHKALGNHAYCQVVKELSRYTTQFRVLALTATPGSDTKAVQQVVSNLLIAQIELCSEDSPEIQPYSHERQVEKIVVPLGEELGGIQRAYIHVLETFAGRLIKLGVLARRDVPSLTKYQIILARDQYRKNPSPQNVGMQPGIIEGDFALCISLYHGYELLQQMGVRSLFIYLCGIMDGSKGLTRTKNELGRNEDFMRLYQQLTDMFSDTCQTSANGNLHKSRTVSENKKEFIYSHPKLKKLEEIVIEHFKSRKMGCSDQTTSGGTCVDTRVMIFSSFRDSVQEIAEMLSRFSPVVRVMTFVGHSTGKSTKGFTQKEQLEVVKRFREGGYNTLVSTCVGEEGLDIGEVDLIICFDAQKSPIRLVQRMGRTGRQRQGRVVVILAEGREERTYNQSQSNRRSIQKAISGNKMLHFYQHSPRMIPEGINPELHRMFITAEKYKPNDSGRLPKGRPSSLHHKSALFSCVTDPKEMHCHENWSLSPEEFEIWDRLYRLKENDGVKEPILPHTRFETLENLDKTSKPEEEAAHKLSLSEWSIWQSRPFPTSMVDHSDRCYHFISVMELIEVMRQEQGDCSYELELQPHLRIEDIHVRRNKGHLSTTSSAFAQKTHSSKRDMARTKRPFVPDVNDNEREFFSIFKTTNTKTPRTAPGLDLEEPELPTDTNGSEPCSARRLTLVASTDQGSPKEEEIEKVTFDLNEFNDLCDDGESTVAHESAAVKDLRLLDKHCSSVGLNHTDLGYSSFTAEKSPASSDLFYLPESHVDSFVLVSSSAELAGLEGAFSCVKGLLAHSPPPVSKLEGIEELLRHEETLCPLPKVSCRSYSGQLPHGDFPSSLAVDQSLLPAESPELEVTIGLSAAVNTCVSKPASTPTAAGGAEERPPGGGSFHSLLGKEGFTANHTDNPPNKHFVQGDEEDSEMKRDVTIDGEKSIHLFEDEHTYKVNDEMPSVDVEPLLRLGSGGHTARPSAGPASQQPPSGDSPRGDTACGEGAARGEMAPGGAWGRGSAAEQALHNSELCDYSQELFSVNFDLGFSIEECEEEIFEGDTDAMNTPKLNSASRSRADVQLTANRKSLNDGCRVQTPPKWDCKGLKGRNISTPLPLQSGHVRDTAVPGGTAGGRTGRGSPGASPPSPATPTGRRVSSAEATRRIRKKVFSTVREETPEVCPTDKVNPNSQRNSFGSSASDALHTTGGRTENLEGTNLHTSRVFPAEGTSSESEEEIVFQRKNRRNNVLRSPDVGSDSDFGSPVCAVRKRRHPLTVSDVSSDDGVDFHKNPNRGTRGCSAAGSKAQLRGVKRQKVRSKVTCKNAARQFLDEEAELSQQDESCVSSDETEDTDKELSSSLAQFLNDDAEVTQVLNDSEMRGVYLKSVRSPALGSRYRMVHREFNSTEIFSQIPEQDEAYAEDSFCVAEGDEETCNKSESSEEEEVCVNFDLLNNESFGGGGGRYLTRRRKKLHGANMEQNCSAPVQKKPSRIIVLSDSSGEETNVSNEKGTAAHCSRAGRENAELLTSMPSVSSVPHKKSAGDVSAHQSAESKSGMLLGLKASVSEVLDFHPGPRSGSGKEALQAAAQHLQLESSVKNSAGNAPGATKASPALLDGDTALCVLVDSREISSGADVISSLKAVHGLKVQVCSLGSGDYVVSNRMAVERKFQSELLSSVNRTKVTQRLQRLQGMFERVCVIVEKDRTRPGETSRFSQRTQHYDATLAALLQAGIRVLFSSCQEETAVLLKELALLEQRKNAAICVPTEVEGHKQEMLNFYLSLPNISYLAALNMCHHFSSVRTMVNSSPSDIAAGARVSLQRAEETYRYLRYGFDTQMLPESLCAKGKSNTATRS", "length": 2041, "header": "sp|A0A1D5PRR9-1|FANCM_CHICK Isoform 1 of Fanconi anemia group M protein OS=Gallus gallus OX=9031 GN=FANCM PE=1 SV=1 CANONICAL=A0A1D5PRR9-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool": "isoglyp", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 1339, "start_aa": "T", "end_pos": 1339, "end_aa": "T", "residue": "Thr", "site_lbl": "Thr1339", "evidence": [ { "id": "GLY_001161", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001161" } ], "filter_code": "00000000000000001000.00000000001000.1.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool": "isoglyp", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 240, "start_aa": "T", "end_pos": 240, "end_aa": "T", "residue": "Thr", "site_lbl": "Thr240", "evidence": [ { "id": "GLY_001161", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001161" } ], "filter_code": "00000000000000001000.00000000001000.1.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution.", "journal": "Nature", "date": "2004", "authors": "", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PRR9", "url": "https://www.uniprot.org/uniprot/A0A1D5PRR9" } ], "reference": [ { "type": "PubMed", "id": "15592404", "url": "https://glygen.org/publication/PubMed/15592404" } ] }, { "title": "The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway.", "journal": "Nature structural & molecular biology", "date": "2005", "authors": "Mosedale G, Niedzwiedz W, Alpi A, Perrina F, Pereira-Leal JB, Johnson M, Langevin F, Pace P, Patel KJ", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PRR9", "url": "https://www.uniprot.org/uniprot/A0A1D5PRR9" } ], "reference": [ { "type": "PubMed", "id": "16116434", "url": "https://glygen.org/publication/PubMed/16116434" } ] }, { "title": "The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair.", "journal": "Nucleic acids research", "date": "2009-07", "authors": "Rosado Ivan V, Niedzwiedz Wojciech, Alpi Arno F, Patel Ketan J", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PRR9", "url": "https://www.uniprot.org/uniprot/A0A1D5PRR9" } ], "reference": [ { "type": "PubMed", "id": "19465393", "url": "https://glygen.org/publication/PubMed/19465393" } ] } ], "pathway": [ { "id": "gga:100857997", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?gga:100857997", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "3'-5' DNA helicase activity", "id": "GO:0043138", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043138", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PRR9", "url": "https://www.uniprot.org/uniprot/A0A1D5PRR9" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PRR9", "url": "https://www.uniprot.org/uniprot/A0A1D5PRR9" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PRR9", "url": "https://www.uniprot.org/uniprot/A0A1D5PRR9" } ], "pmid": "" }, { "name": "nuclease activity", "id": "GO:0004518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004518", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PRR9", "url": "https://www.uniprot.org/uniprot/A0A1D5PRR9" } ], "pmid": "" }, { "name": "four-way junction DNA binding", "id": "GO:0000400", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000400", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PRR9", "url": "https://www.uniprot.org/uniprot/A0A1D5PRR9" } ], "pmid": "" }, { "name": "four-way junction helicase activity", "id": "GO:0009378", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009378", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PRR9", "url": "https://www.uniprot.org/uniprot/A0A1D5PRR9" } ], "pmid": "" }, { "name": "RNA helicase activity", "id": "GO:0003724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003724", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PRR9", "url": "https://www.uniprot.org/uniprot/A0A1D5PRR9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PRR9", "url": "https://www.uniprot.org/uniprot/A0A1D5PRR9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "interstrand cross-link repair", "id": "GO:0036297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036297", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PRR9", "url": "https://www.uniprot.org/uniprot/A0A1D5PRR9" } ], "pmid": "" }, { "name": "double-strand break repair via synthesis-dependent strand annealing", "id": "GO:0045003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045003", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PRR9", "url": "https://www.uniprot.org/uniprot/A0A1D5PRR9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1103, "end_pos": 1105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1299, "end_pos": 1301, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1563, "end_pos": 1565, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1592, "end_pos": 1594, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1623, "end_pos": 1625, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1642, "end_pos": 1644, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1668, "end_pos": 1670, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1692, "end_pos": 1694, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1866, "end_pos": 1868, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1971, "end_pos": 1973, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1992, "end_pos": 1994, "annotation": "n_glycosylation_sequon" }, { "start_pos": 598, "end_pos": 600, "annotation": "n_glycosylation_sequon" }, { "start_pos": 648, "end_pos": 650, "annotation": "n_glycosylation_sequon" }, { "start_pos": 682, "end_pos": 684, "annotation": "n_glycosylation_sequon" }, { "start_pos": 869, "end_pos": 871, "annotation": "n_glycosylation_sequon" }, { "start_pos": 939, "end_pos": 941, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Phosphorylated; hyperphosphorylated in response to genotoxic stress.", "evidence": [ { "database": "UniProtKB", "id": "A0A1D5PRR9", "url": "https://www.uniprot.org/uniprot/A0A1D5PRR9" }, { "database": "PubMed", "id": "19465393", "url": "https://glygen.org/publication/PubMed/19465393" } ] } ], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A8V0X2U4-1", "A0A1D5PHB6-1", "A0A8V0XT73-1", "A0A8V0XJV9-1", "A0A8V1AJ43-1", "A0A1D5PIN7-1", "A0A8V0ZC95-1", "A0A8V0ZVY2-1", "A0A8V0ZU49-1", "A0A8V0ZHE4-1", "A0A8V0ZFN9-1", "A0A8V0YHC8-1", "A0A8V0XZB8-1", "A0A8V0YMT9-1", "F1NTD6-1", "P53478-1", "Q5F485-1", "Q5ZHZ0-1", "Q5ZI74-1", "Q5ZIW1-1", "Q5ZKB9-1", "Q5ZKD7-1", "Q5ZM36-1", "Q5ZMN2-1", "A0A8V0XLC7-1", "A0A8V0YJ39-1", "F1NFJ0-1", "A0A8V0YT68-1", "A0A8V0YU49-1", "A0A8V0ZPN6-1", 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[ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A3S5ZPN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A3S5ZPN3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3S5ZPN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A3S5ZPN3" } ] } ] }, { "uniprot_ac": "A0A8V0X2U4", "gene_name": "LOC100857358", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8V0X2U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0X2U4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A8V0X2U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0X2U4" } ] } ] }, { "uniprot_ac": "A0A8V0X9Y7", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "A0A8V0X9Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0X9Y7" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "A0A8V0X9Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0X9Y7" } ] } ] }, { "uniprot_ac": "A0A8V0X9Z6", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8V0X9Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0X9Z6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A8V0X9Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0X9Z6" } ] } ] }, { "uniprot_ac": "A0A8V0XEC4", "gene_name": "DDX10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8V0XEC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0XEC4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A8V0XEC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0XEC4" } ] } ] }, { "uniprot_ac": "A0A8V0XI26", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8V0XI26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0XI26" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A8V0XI26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0XI26" } ] } ] }, { "uniprot_ac": "A0A8V0XJV9", "gene_name": "SPATA5", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8V0XJV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0XJV9" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0A8V0XJV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0XJV9" } ] } ] }, { "uniprot_ac": "A0A8V0XLC7", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8V0XLC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0XLC7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A8V0XLC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0XLC7" } ] } ] }, { "uniprot_ac": "A0A8V0XR90", "gene_name": "WRN", "activity": [ { "ec_number": "5.6.2.4", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.", "evidence": [ { "id": "A0A8V0XR90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0XR90" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A8V0XR90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0XR90" } ] } ] }, { "uniprot_ac": "A0A8V0XSI7", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A0A8V0XSI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0XSI7" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A0A8V0XSI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0XSI7" } ] } ] }, { "uniprot_ac": "A0A8V0XT73", "gene_name": "FBXO18", "activity": [ { "ec_number": "5.6.2.4", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.", "evidence": [ { "id": "A0A8V0XT73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0XT73" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A8V0XT73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0XT73" } ] } ] }, { "uniprot_ac": "A0A8V0XZB8", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": 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"activity": "", "evidence": [ { "id": "A0A8V0ZR10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0ZR10" } ] } ] }, { "uniprot_ac": "A0A8V0ZS56", "gene_name": "HFM1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8V0ZS56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0ZS56" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A8V0ZS56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0ZS56" } ] } ] }, { "uniprot_ac": "A0A8V0ZSJ1", "gene_name": "CHD6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8V0ZSJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0ZSJ1" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A8V0ZSJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8V0ZSJ1" } ] } ] }, 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