{ "uniprot_canonical_ac": "A0A1B0GS01-1", "uniprot_ac": "A0A1B0GS01", "uniprot_id": "A0A1B0GS01_MOUSE", "mass": { "chemical_mass": 25488.0, "monoisotopic_mass": 25488.0 }, "refseq": {}, "gene_names": [ { "name": "Pvrig", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A1B0GS01", "id": "A0A1B0GS01" } ], "protein_names": [ { "name": "Poliovirus receptor related immunoglobulin domain containing", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A1B0GS01/entry#names_and_taxonomy", "id": "A0A1B0GS01" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A0A1B0GS01", "url": "https://www.uniprot.org/uniprot/A0A1B0GS01" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "gene": [ { "name": "Pvrig", "url": "https://www.uniprot.org/uniprot/A0A1B0GS01", "locus": { "chromosome": "5", "start_pos": 138341819, "end_pos": 138340223, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000109713", "url": "https://www.ensembl.org/id/ENSMUSG00000109713" } ] } } ], "crossref": [ { "id": "A0A1B0GS01", "url": "https://alphafold.ebi.ac.uk/entry/A0A1B0GS01", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSMUSG00000109713", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000109713", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "GPDB0001522", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0001522", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "IPR034452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "5596028", "url": "http://www.informatics.jax.org/marker/MGI:5596028", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "GTQQWAP", "url": "https://omabrowser.org/oma/group/GTQQWAP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A1B0GS01", "url": "https://www.orthodb.org/?gene=A0A1B0GS01", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR39220", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR39220", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR39220:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR39220:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_011239268", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011239268", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A1B0GS01", "url": "https://www.uniprot.org/uniprot/A0A1B0GS01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1B0GS01-1", "url": "https://www.uniprot.org/uniprot/A0A1B0GS01-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRTGNTQAAHATNMGQMQTLVLFSTLLTLCVSEASPEVWVQVQMEATNLSSFSVHCGVLGYSLISLVTVSCEGFVDAGRTKLAVLHPEFGTQQWAPARQAHWETPNSVSVTLTMGQSKARSSLANTTFCCEFVTFPHGSRVACRDLHRSDPGLSAPTPALNLQADLVRILGTSGVFLFGFIFILCLRWQQRHWCLSKSQPSLTSTQAQVETQPPHLASTHSSFISMENGLYALA", "length": 234, "header": "tr|A0A1B0GS01-1|A0A1B0GS01_MOUSE Isoform 1 of Poliovirus receptor related immunoglobulin domain containing OS=Mus musculus OX=10090 GN=Pvrig PE=4 SV=1 CANONICAL=A0A1B0GS01-1" }, "isoforms": [ { "isoform_ac": "A0A1B0GS01-1", "url": "https://www.uniprot.org/uniprotkb/A0A1B0GS01/entry#A0A1B0GS01-1", "sequence": { "sequence": "MRTGNTQAAHATNMGQMQTLVLFSTLLTLCVSEASPEVWVQVQMEATNLSSFSVHCGVLGYSLISLVTVSCEGFVDAGRTKLAVLHPEFGTQQWAPARQAHWETPNSVSVTLTMGQSKARSSLANTTFCCEFVTFPHGSRVACRDLHRSDPGLSAPTPALNLQADLVRILGTSGVFLFGFIFILCLRWQQRHWCLSKSQPSLTSTQAQVETQPPHLASTHSSFISMENGLYALA", "length": 234, "header": "tr|A0A1B0GS01-1|A0A1B0GS01_MOUSE Isoform 1 of Poliovirus receptor related immunoglobulin domain containing OS=Mus musculus OX=10090 GN=Pvrig PE=4 SV=1 CANONICAL=A0A1B0GS01-1" }, "locus": { "chromosome": "5", "start_pos": 138341449, "end_pos": 138340231, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000211088.2", "url": "https://www.ensembl.org/id/ENSMUST00000211088.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000147735.2", "url": "https://www.ensembl.org/id/ENSMUSP00000147735.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool": "isoglyp", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 157, "start_aa": "T", "end_pos": 157, "end_aa": "T", "residue": "Thr", "site_lbl": "Thr157", "evidence": [ { "id": "GLY_001153", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001153" } ], "filter_code": "00000000000000001000.00000000001000.1.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K8H7-1", "protein_name": "PVR related immunoglobulin domain containing", "gene_name": "Pvrig", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRTNTQAVPATNMAQMQTLVLFSTLLILCVSAASPEVWVQVQMEATNLSFFSVHCGVLGCNHISLVTVSWKGFVDARETKLAVLHPEFGTQQWAPASQAHWETPISISVTLTLEQSKARSSLANTTFCCEFVTFPHGSRVACRDLHSSDPGLSALTPAPSLQADLAGILGTSGFFLFGFIFILCLRWWQRHRCSRKSQLSLSRTQAQMETPLPHLASIQGSFIFVDNGLYTLA", "length": 233 }, "evidence": [ { "id": "A0A1B0GS01", "url": "https://omabrowser.org/oma/group/A0A1B0GS01/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0AAA9SAK7-1", "protein_name": "PVR related immunoglobulin domain containing", "gene_name": "PVRIG", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MTVPLALAAGSQLPSAVGRKVQMEQSSAGRSQPSCAWQAPLPLPRFCHIPFREVGGVVCVSAFFLKTNQGVCPSPGKDIVSGPPAAYLPSEPPPTPGLIQRRKWGRFAESTQQLLPGPLILIRKTSCDDTGNTSAVPTTTAPWSPGQRGAMDRPRALGLLWVLLTLCLTAGTPEVWLQVQREATEASFTVRCGFLGSGSISLVTVSYGGPDSAGGTTLAVLHPTLGTKNWTAACRARWETSTSISLTLERAPTAAGDSSPNTTFCCKFTSFPEGSQEACGKLSASTDQELPAPSPASVLRADLAGILGVSGVLLSGCIYLLYLLCRQRHWSVMKLQPPRHGSPQTDGRTSAAGQASLTSFHVPYATAATTSNYFSPATLHPVPPPQPLPGWVPPLTHAARRPQSPGPWAPPPASARSSFVSVENRLYAQTEKRPLHAGADHISLPDRLGRKAALGPSGVR", "length": 460 }, "evidence": [ { "id": "A0A1B0GS01", "url": "https://omabrowser.org/oma/group/A0A1B0GS01/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "F1RNL9-1", "protein_name": "PVR related immunoglobulin domain containing", "gene_name": "PVRIG", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDRPRALGLLLALLTLCITAGTPEVWVQVRMEATESLSFTVRCGFLGSGSISLVTVSYGGPDGAGGTKLAVLHPTLGTQHWAPACQAHWETRSSISLTLEASEGRSSRHNTTFCCRFTSFPEGSQEACGNLSLSTDQGLAAPTPAPVLRADLAGILGVSGVFFFGSIYLLYLLRRQRHWSVTKLQPPRQNSPQTQRRASAAGQASLTSLHGPCATISTSYLCPASLHPVLPPQPLPKWATLPAHPARRPQSLARWAPPPGSVRSSFVSMENWLYAQAGTRPLHARATPSPLLGPLGPRATKEDLAAR", "length": 307 }, "evidence": [ { "id": "A0A1B0GS01", "url": "https://omabrowser.org/oma/group/A0A1B0GS01/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6DKI7-1", "protein_name": "Transmembrane protein PVRIG", "gene_name": "PVRIG", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRTEAQVPALQPPEPGLEGAMGHRTLVLPWVLLTLCVTAGTPEVWVQVRMEATELSSFTIRCGFLGSGSISLVTVSWGGPNGAGGTTLAVLHPERGIRQWAPARQARWETQSSISLILEGSGASSPCANTTFCCKFASFPEGSWEACGSLPPSSDPGLSAPPTPAPILRADLAGILGVSGVLLFGCVYLLHLLRRHKHRPAPRLQPSRTSPQAPRARAWAPSQASQAALHVPYATINTSCRPATLDTAHPHGGPSWWASLPTHAAHRPQGPAAWASTPIPARGSFVSVENGLYAQAGERPPHTGPGLTLFPDPRGPRAMEGPLGVR", "length": 326 }, "evidence": [ { "id": "A0A1B0GS01", "url": "https://omabrowser.org/oma/group/A0A1B0GS01/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A1B0GS01", "url": "https://www.uniprot.org/uniprot/A0A1B0GS01" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of T cell receptor signaling pathway", "id": "GO:0050860", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050860", "evidence": [ { "database": "UniProtKB", "id": "A0A1B0GS01", "url": "https://www.uniprot.org/uniprot/A0A1B0GS01" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "signaling receptor activity", "id": "GO:0038023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038023", "evidence": [ { "database": "UniProtKB", "id": "A0A1B0GS01", "url": "https://www.uniprot.org/uniprot/A0A1B0GS01" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 125, "end_pos": 127, "annotation": "n_glycosylation_sequon" }, { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A1B0GS01-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 234, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A1B0GS01-F1.pdb" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 157 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 125, "end_pos": 127 }, { "start_pos": 48, "end_pos": 50 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "prediction_tool", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "prediction_tool", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }