{ "uniprot_canonical_ac": "A0A167VDT2-1", "uniprot_ac": "A0A167VDT2", "uniprot_id": "A0A167VDT2_CHICK", "mass": { "chemical_mass": 76681.0, "monoisotopic_mass": 76681.0 }, "refseq": {}, "gene_names": [ { "name": "TP63", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A167VDT2", "id": "A0A167VDT2" } ], "protein_names": [ { "name": "Tumor protein 63 (p63)", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A167VDT2/entry#names_and_taxonomy", "id": "A0A167VDT2" } ], "function": [ { "annotation": "Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.", "evidence": [ { "database": "UniProtKB", "id": "A0A8V0YWX3", "url": "https://www.uniprot.org/uniprot/A0A8V0YWX3#function" }, { "database": "UniProtKB", "id": "RU003304", "url": "https://www.uniprot.org/uniprot/RU003304#function" }, { "database": "UniProtKB", "id": "A0A3Q2TZ71", "url": "https://www.uniprot.org/uniprot/A0A3Q2TZ71#function" }, { "database": "UniProtKB", "id": "F1NWD0", "url": "https://www.uniprot.org/uniprot/F1NWD0#function" }, { "database": "UniProtKB", "id": "A0A3Q3A2R8", "url": "https://www.uniprot.org/uniprot/A0A3Q3A2R8#function" }, { "database": "UniProtKB", "id": "A0A8V0YIP3", "url": "https://www.uniprot.org/uniprot/A0A8V0YIP3#function" }, { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2#function" } ] }, { "annotation": "Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.", "evidence": [ { "database": "UniProtKB", "id": "A0A8V0YWV8", "url": "https://www.uniprot.org/uniprot/A0A8V0YWV8#function" }, { "database": "UniProtKB", "id": "RU003304", "url": "https://www.uniprot.org/uniprot/RU003304#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Gallus gallus", "taxid": 9031, "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "common_name": "Chicken", "glygen_name": "Chicken", "reference_species": "Gallus gallus [9031]" } ], "gene": [ { "name": "TP63", "url": "https://www.uniprot.org/uniprot/A0A167VDT2", "locus": { "chromosome": "9", "start_pos": 13741157, "end_pos": 13853956, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSGALG00010014867", "url": "https://www.ensembl.org/id/ENSGALG00010014867" } ] } } ], "crossref": [ { "id": "ENSGALG00000007324", "url": "https://bgee.org/?page=gene&gene_id=ENSGALG00000007324", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08367", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08367", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09572", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09572", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002117", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002117", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008967", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008967", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010991", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010991", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011615", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011615", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012346", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012346", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036674", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036674", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IRMQDSE", "url": "https://omabrowser.org/oma/group/IRMQDSE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A167VDT2", "url": "https://www.orthodb.org/?gene=A0A167VDT2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11447", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11447", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11447:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11447:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00870", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00870", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07647", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07647", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07710", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07710", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-GGA-6804759", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-6804759", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_015146847", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015146847", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A167VDT2-1", "url": "https://www.uniprot.org/uniprot/A0A167VDT2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q2TZ71", "url": "https://www.uniprot.org/uniprot/A0A3Q2TZ71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q2TZ71-1", "url": "https://www.uniprot.org/uniprot/A0A3Q2TZ71-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q3A2R8", "url": "https://www.uniprot.org/uniprot/A0A3Q3A2R8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q3A2R8-1", "url": "https://www.uniprot.org/uniprot/A0A3Q3A2R8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0YIP3", "url": "https://www.uniprot.org/uniprot/A0A8V0YIP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0YIP3-1", "url": "https://www.uniprot.org/uniprot/A0A8V0YIP3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0YWV8", "url": "https://www.uniprot.org/uniprot/A0A8V0YWV8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0YWV8-1", "url": "https://www.uniprot.org/uniprot/A0A8V0YWV8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0YWX3", "url": "https://www.uniprot.org/uniprot/A0A8V0YWX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8V0YWX3-1", "url": "https://www.uniprot.org/uniprot/A0A8V0YWX3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1NWD0", "url": "https://www.uniprot.org/uniprot/F1NWD0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1NWD0-1", "url": "https://www.uniprot.org/uniprot/F1NWD0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNFEAAPFSTLQYYPDPCIPRFVETPSHFSWKESYYRSAMSQSSQPREFLSPEVIQHIWDFLEQPICSVQPIDLNFIDDPSENGPTNKIEISMDCVRLQDTELSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTEHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQGTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSQSSYGSNSPPLSKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGTNIPMMGTHMAMTGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCVDYFTTQGLTTIYQIEHYSMDDLVSLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDARRNKQQRIKEEGE", "length": 680, "header": "tr|A0A167VDT2-1|A0A167VDT2_CHICK Isoform 1 of Tumor protein 63 (p63) OS=Gallus gallus OX=9031 GN=TP63 PE=2 SV=1 CANONICAL=A0A167VDT2-1" }, "isoforms": [ { "isoform_ac": "A0A167VDT2-1", "url": "https://www.uniprot.org/uniprotkb/A0A167VDT2/entry#A0A167VDT2-1", "sequence": { "sequence": "MNFEAAPFSTLQYYPDPCIPRFVETPSHFSWKESYYRSAMSQSSQPREFLSPEVIQHIWDFLEQPICSVQPIDLNFIDDPSENGPTNKIEISMDCVRLQDTELSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTEHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQGTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSQSSYGSNSPPLSKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGTNIPMMGTHMAMTGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCVDYFTTQGLTTIYQIEHYSMDDLVSLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDARRNKQQRIKEEGE", "length": 680, "header": "tr|A0A167VDT2-1|A0A167VDT2_CHICK Isoform 1 of Tumor protein 63 (p63) OS=Gallus gallus OX=9031 GN=TP63 PE=2 SV=1 CANONICAL=A0A167VDT2-1" }, "locus": { "chromosome": "9", "start_pos": 13837557, "end_pos": 13743886, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010035859.1", "url": "https://www.ensembl.org/id/ENSGALT00010035859.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010020797.1", "url": "https://www.ensembl.org/id/ENSGALP00010020797.1" } ] } }, { "isoform_ac": "A0A3Q2TZ71-1", "url": "https://www.uniprot.org/uniprotkb/A0A167VDT2/entry#A0A3Q2TZ71-1", "sequence": { "sequence": "MSQSSQPREFLSPEVIQHIWDFLEQPICSVQPIDLNFIDDPSENGPTNKIEISMDCVRLQDTELSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTEHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDAFRQGTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSQSSYGSNSPPLSKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGTNIPMMGTHMAMTGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCVDYFTTQGLTTIYQIEHYSMDDLVSLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDARRNKQQRIKEEGE", "length": 637, "header": "tr|A0A3Q2TZ71-1|A0A167VDT2_CHICK Computationally mapped isoform of Tumor protein 63 (p63) OS=Gallus gallus OX=9031 GN=TP63 PE=2 SV=1 CANONICAL=A0A167VDT2-1" }, "locus": { "chromosome": "9", "start_pos": 13821140, "end_pos": 13743886, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010035854.1", "url": "https://www.ensembl.org/id/ENSGALT00010035854.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010020793.1", "url": "https://www.ensembl.org/id/ENSGALP00010020793.1" } ] } }, { "isoform_ac": "A0A3Q3A2R8-1", "url": "https://www.uniprot.org/uniprotkb/A0A167VDT2/entry#A0A3Q3A2R8-1", "sequence": { "sequence": "MSQSSQPREFLSPEVIQHIWDFLEQPICSVQPIDLNFIDDPSENGPTNKIEISMDCVRLQDTELSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTEHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQGTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSQSSYGSNSPPLSKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGTNIPMMGTHMAMTGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCVDYFTTQGLTTIYQIEHYSMDDLVSLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDARRNKQQRIKEEGE", "length": 641, "header": "tr|A0A3Q3A2R8-1|A0A3Q3A2R8_CHICK Computationally mapped isoform of Tumor protein 63 (p63) OS=Gallus gallus OX=9031 GN=TP63 PE=3 SV=1 CANONICAL=A0A167VDT2-1" }, "locus": { "chromosome": "9", "start_pos": 13821140, "end_pos": 13743886, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010035868.1", "url": "https://www.ensembl.org/id/ENSGALT00010035868.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010020806.1", "url": "https://www.ensembl.org/id/ENSGALP00010020806.1" } ] } }, { "isoform_ac": "A0A8V0YIP3-1", "url": "https://www.uniprot.org/uniprotkb/A0A167VDT2/entry#A0A8V0YIP3-1", "sequence": { "sequence": "MLYVLHHDGHPQYTNLGLLNSMDQQIQNGSSSTSPYNTEHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQGTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSQSSYGSNSPPLSKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGTNIPMMGTHMAMTGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCVDYFTTQGLTTIYQIEHYSMDDLVSLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDARRNKQQRIKEEGE", "length": 582, "header": "tr|A0A8V0YIP3-1|A0A8V0YIP3_CHICK Computationally mapped isoform of Tumor protein 63 (p63) OS=Gallus gallus OX=9031 GN=TP63 PE=3 SV=1 CANONICAL=A0A167VDT2-1" }, "locus": { "chromosome": "9", "start_pos": 13790081, "end_pos": 13743886, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010035834.1", "url": "https://www.ensembl.org/id/ENSGALT00010035834.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010020780.1", "url": "https://www.ensembl.org/id/ENSGALP00010020780.1" } ] } }, { "isoform_ac": "A0A8V0YWV8-1", "url": "https://www.uniprot.org/uniprotkb/A0A167VDT2/entry#A0A8V0YWV8-1", "sequence": { "sequence": "MLYLENNAQSQYSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTEHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQGTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKHLLSACFRSELVDSRRDSPKQTDTILKHSSPPKPSVYP", "length": 393, "header": "tr|A0A8V0YWV8-1|A0A167VDT2_CHICK Computationally mapped isoform of Tumor protein 63 (p63) OS=Gallus gallus OX=9031 GN=TP63 PE=2 SV=1 CANONICAL=A0A167VDT2-1" }, "locus": { "chromosome": "9", "start_pos": 13806687, "end_pos": 13754130, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010035842.1", "url": "https://www.ensembl.org/id/ENSGALT00010035842.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010020786.1", "url": "https://www.ensembl.org/id/ENSGALP00010020786.1" } ] } }, { "isoform_ac": "A0A8V0YWX3-1", "url": "https://www.uniprot.org/uniprotkb/A0A167VDT2/entry#A0A8V0YWX3-1", "sequence": { "sequence": "MLRGGEILAQKMPSWFVETPSHFSWKESYYRSAMSQSSQPREFLSPEVIQHIWDFLEQPICSVQPIDLNFIDDPSENGPTNKIEISMDCVRLQDTELSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTEHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQGTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSQSSYGSNSPPLSKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGTNIPMMGTHMAMTGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCVDYFTTQGLTTIYQIEHYSMDDLVSLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDARRNKQQRIKEEGE", "length": 674, "header": "tr|A0A8V0YWX3-1|A0A167VDT2_CHICK Computationally mapped isoform of Tumor protein 63 (p63) OS=Gallus gallus OX=9031 GN=TP63 PE=2 SV=1 CANONICAL=A0A167VDT2-1" }, "locus": { "chromosome": "9", "start_pos": 13837804, "end_pos": 13743886, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010035863.1", "url": "https://www.ensembl.org/id/ENSGALT00010035863.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010020801.1", "url": "https://www.ensembl.org/id/ENSGALP00010020801.1" } ] } }, { "isoform_ac": "F1NWD0-1", "url": "https://www.uniprot.org/uniprotkb/A0A167VDT2/entry#F1NWD0-1", "sequence": { "sequence": "MLYLENNAQSQYSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTEHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQGTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSQSSYGSNSPPLSKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGTNIPMMGTHMAMTGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCVDYFTTQGLTTIYQIEHYSMDDLVSLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDARRNKQQRIKEEGE", "length": 586, "header": "tr|F1NWD0-1|A0A167VDT2_CHICK Computationally mapped isoform of Tumor protein 63 (p63) OS=Gallus gallus OX=9031 GN=TP63 PE=2 SV=2 CANONICAL=A0A167VDT2-1" }, "locus": { "chromosome": "9", "start_pos": 13806687, "end_pos": 13743886, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSGALT00010035848.1", "url": "https://www.ensembl.org/id/ENSGALT00010035848.1" }, { "database": "Ensembl Peptide", "id": "ENSGALP00010020790.1", "url": "https://www.ensembl.org/id/ENSGALP00010020790.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool": "isoglyp", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 545, "start_aa": "T", "end_pos": 545, "end_aa": "T", "residue": "Thr", "site_lbl": "Thr545", "evidence": [ { "id": "GLY_001161", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001161" } ], "filter_code": "00000000000000001000.00000000001000.1.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-GGA-6804759", "name": "Regulation of TP53 Activity through Association with Co-factors", "url": "https://www.reactome.org/PathwayBrowser/#R-GGA-6804759", "resource": "Reactome", "description": "Regulation of TP53 Activity through Association with Co-factors" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1UD21-1", "protein_name": "Tumor protein 63 (p63)", "gene_name": "TP63", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTSEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSENGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSMQSQSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSLVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDARRNKQQRIKEEGE", "length": 680 }, "evidence": [ { "id": "A0A167VDT2", "url": "https://omabrowser.org/oma/group/A0A167VDT2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1MKA9-1", "protein_name": "Tumor protein 63 (p63)", "gene_name": "TP63", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTSEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSENGATNKIEISMDCIRMQDSDLGDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSMQSQSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSLVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDARRNKQQRIKEEGE", "length": 680 }, "evidence": [ { "id": "A0A167VDT2", "url": "https://omabrowser.org/oma/group/A0A167VDT2/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "O88898-1", "protein_name": "Tumor protein 63", "gene_name": "Tp63", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNFETSRCATLQYCPDPYIQRFIETPAHFSWKESYYRSAMSQSTQTSEFLSPEVFQHIWDFLEQPICSVQPIELNFVDEPSENGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSAKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSMQSQSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTMPEGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDSRRNKQQRIKEEGE", "length": 680 }, "evidence": [ { "id": "A0A167VDT2", "url": "https://omabrowser.org/oma/group/A0A167VDT2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H3D4-1", "protein_name": "Tumor protein 63", "gene_name": "TP63", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHEFSSPSHLLRTPSSASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDARRNKQQRIKEEGE", "length": 680 }, "evidence": [ { "id": "A0A167VDT2", "url": "https://omabrowser.org/oma/group/A0A167VDT2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JJP6-1", "protein_name": "Tumor protein 63", "gene_name": "Tp63", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNFETSRCATLQYCPDPYIQRFIETPSHFSWKESYYRSAMSQSTQTSEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSENGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNGMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSAKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSMQSQSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTMPEGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDSRRNKQQRIKEEGE", "length": 680 }, "evidence": [ { "id": "A0A167VDT2", "url": "https://omabrowser.org/oma/group/A0A167VDT2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 12, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "damaged DNA binding", "id": "GO:0003684", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003684", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "WW domain binding", "id": "GO:0050699", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050699", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "p53 binding", "id": "GO:0002039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002039", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "MDM2/MDM4 family protein binding", "id": "GO:0097371", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097371", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "promoter-specific chromatin binding", "id": "GO:1990841", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990841", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 43, "go_terms": [ { "name": "protein tetramerization", "id": "GO:0051262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051262", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "cranial skeletal system development", "id": "GO:1904888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904888", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "positive regulation of stem cell proliferation", "id": "GO:2000648", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000648", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "negative regulation of keratinocyte differentiation", "id": "GO:0045617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045617", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "Notch signaling pathway", "id": "GO:0007219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007219", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "neuron apoptotic process", "id": "GO:0051402", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051402", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "establishment of skin barrier", "id": "GO:0061436", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061436", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "positive regulation of apoptotic signaling pathway", "id": "GO:2001235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001235", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "keratinocyte differentiation", "id": "GO:0030216", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030216", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "skeletal system development", "id": "GO:0001501", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001501", "evidence": [ { "database": "UniProtKB", "id": "A0A167VDT2", "url": "https://www.uniprot.org/uniprot/A0A167VDT2" } ], "pmid": "" }, { "name": "intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator", "id": "GO:0042771", "url": 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