{ "uniprot_canonical_ac": "A0A0G2KB72-1", "uniprot_ac": "A0A0G2KB72", "uniprot_id": "A0A0G2KB72_RAT", "mass": { "chemical_mass": 71772.0, "monoisotopic_mass": 71772.0 }, "refseq": {}, "gene_names": [ { "name": "Phldb3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2KB72", "id": "A0A0G2KB72" } ], "protein_names": [ { "name": "Pleckstrin homology-like domain, family B, member 3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KB72/entry#names_and_taxonomy", "id": "A0A0G2KB72" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB72", "url": "https://www.uniprot.org/uniprot/A0A0G2KB72" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Phldb3", "url": "https://www.uniprot.org/uniprot/A0A0G2KB72", "locus": { "chromosome": "1", "start_pos": 80219534, "end_pos": 80201578, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000055259", "url": "https://www.ensembl.org/id/ENSRNOG00000055259" } ] } } ], "crossref": [ { "id": "A0A0G2KB72", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2KB72", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000055259", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000055259", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052212", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052212", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MGTRSRP", "url": "https://omabrowser.org/oma/group/MGTRSRP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12156", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12156", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12156:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12156:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "1561121", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1561121", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2KB72", "url": "https://www.uniprot.org/uniprot/A0A0G2KB72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2KB72-1", "url": "https://www.uniprot.org/uniprot/A0A0G2KB72-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTPSTLEEGSLPPQVPECAVEVQPQGVVQPQGHPENPQEHKEPEVPAELPSCQEAGRQEEEEEVEEGSSTESCREEPEATLAAQIPATPSPCLPGEELRGAARRLRGQQLEALTRVALMEQRVKELQRQKKELRIEMEVEVALLRGELAGERVAARREEEQLRELLGQRVESQQSSQEQREQEQRQLSQERDHVENLRQRLREAQGHLDSQPEDQRERLSQGVQEIREQLDAAQRTYEDLEFQQLERESRVEEERESPDVPAPDSKVRELQASVAQHKRRILVLEEQLRSLGEQMAAESWGLSRKKEEAVQALTQERSRLFELNCLQGTCGGDFSEPDQALTKLLFTQKTDRQLLVLQDPIAHAAASSTSSCLFSVHSSLQGSIGLQRTGSLPRRRGDRASQRGSSRPLSVHCTGPLEASALTQAVGTPGRHPLYQLLNCGPGNRNPVLHPDIAHMERLLKQAVAERERLLKAREGMKRSQESSTDPAVPAIMAPPHPPGPQDLDLAQHLERWGHNPESCPHLRVSGGYCRGPLVKMGGRIKTWRKRWFCFDRQARRLAYYADKEESKLKGVIYFQAIEEVYCDHLRCASKSPNPLLTFCVKTYERLFYMVAPNPEAMRIWMVVIGTAADENHAP", "length": 636, "header": "tr|A0A0G2KB72-1|A0A0G2KB72_RAT Isoform 1 of Pleckstrin homology-like domain, family B, member 3 OS=Rattus norvegicus OX=10116 GN=Phldb3 PE=4 SV=2 CANONICAL=A0A0G2KB72-1" }, "isoforms": [ { "isoform_ac": "A0A0G2KB72-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KB72/entry#A0A0G2KB72-1", "sequence": { "sequence": "MGTPSTLEEGSLPPQVPECAVEVQPQGVVQPQGHPENPQEHKEPEVPAELPSCQEAGRQEEEEEVEEGSSTESCREEPEATLAAQIPATPSPCLPGEELRGAARRLRGQQLEALTRVALMEQRVKELQRQKKELRIEMEVEVALLRGELAGERVAARREEEQLRELLGQRVESQQSSQEQREQEQRQLSQERDHVENLRQRLREAQGHLDSQPEDQRERLSQGVQEIREQLDAAQRTYEDLEFQQLERESRVEEERESPDVPAPDSKVRELQASVAQHKRRILVLEEQLRSLGEQMAAESWGLSRKKEEAVQALTQERSRLFELNCLQGTCGGDFSEPDQALTKLLFTQKTDRQLLVLQDPIAHAAASSTSSCLFSVHSSLQGSIGLQRTGSLPRRRGDRASQRGSSRPLSVHCTGPLEASALTQAVGTPGRHPLYQLLNCGPGNRNPVLHPDIAHMERLLKQAVAERERLLKAREGMKRSQESSTDPAVPAIMAPPHPPGPQDLDLAQHLERWGHNPESCPHLRVSGGYCRGPLVKMGGRIKTWRKRWFCFDRQARRLAYYADKEESKLKGVIYFQAIEEVYCDHLRCASKSPNPLLTFCVKTYERLFYMVAPNPEAMRIWMVVIGTAADENHAP", "length": 636, "header": "tr|A0A0G2KB72-1|A0A0G2KB72_RAT Isoform 1 of Pleckstrin homology-like domain, family B, member 3 OS=Rattus norvegicus OX=10116 GN=Phldb3 PE=4 SV=2 CANONICAL=A0A0G2KB72-1" }, "locus": { "chromosome": "1", "start_pos": 80219221, "end_pos": 80201584, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000083493.2", "url": "https://www.ensembl.org/id/ENSRNOT00000083493.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000075680.2", "url": "https://www.ensembl.org/id/ENSRNOP00000075680.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool": "isoglyp", "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 89, "start_aa": "T", "end_pos": 89, "end_aa": "T", "residue": "Thr", "site_lbl": "Thr89", "evidence": [ { "id": "GLY_001157", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001157" } ], "filter_code": "00000000000000001000.00000000001000.1.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "E9QAF4-1", "protein_name": "Pleckstrin homology like domain, family B, member 3", "gene_name": "Phldb3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGTPSTLEEGSSSPKVSECAVEVQPQGAVQPQGHPEDPKEHKEPEVPAELPSCPGAGRQAEEEEEVEEGSSTESCREEPEATPAAQIPATPSPCLPSGEELRGAARRLRGQQLEALTRVALMEQRVKELQRQKKELRIEMEVEVALLRGELAGERVAARREEEQLRELLGQRVETQPSSQEQREQEQRQLSQERDHVESLRQRLREAQGQLDSQPEDQRERLSQGVQEIREQLDAAQRTYEDLEFQQLERESRVEEERESPAVPAPDSKVRELQSSVAQHRRRIQVLEEQLRSLGEQMAAESWGLSRKKEEAVQALTQERSRLFELNCLQGTCGGDFSEPDQALTKLLFTQKTDRQLLVLQDPTAHAAASSTSSCLFSVHSSLQGSIGLQRTGSLPRRRGERASQRGSSRPLSLHCTGPLEASALSQAVGTPGRHPLYQLLNCGPGNRHSVLRSDIAHMERLLQLAVAERERLLKDREGMRRSRESSTGPAVPAITAPPPPPPPPPPPPSPPGPQVLDLPQHLERWGHNPESCPHLRVTGGCCRGPLVKMGGRIKTWRKRWFCFDRQARRLAYYADKEETKLKGVIYFQAIEEVYYDHLRCAFKSPSPRLTFCVKTYERLFYMVAPSPEAMRIWMDVIVTAADENHAP", "length": 648 }, "evidence": [ { "id": "A0A0G2KB72", "url": "https://omabrowser.org/oma/group/A0A0G2KB72/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F1MSN5-1", "protein_name": "Pleckstrin homology like domain family B member 3", "gene_name": "PHLDB3", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MGTRSRPDLGAPPAAVPECDTEVRSQGASKPQGHPKDSREPEAPEAPAELPSGQGAEQQAKEEEEVGEGSSTESSHDAAEAPSPVQTPATTPAPALSGEGVRGAARRLRAQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLGQQVDSEKGGQEQREQEQRRLSQERDRVEGLRQRLQEAQEQLDSQPEDQHERLLQGMQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGASVPDPKVQELQASVAQHRRRIQVLEEQLKSLGEQMAAESRGLSRKKEEALQALTQERSRLLELNCLQGTPGGDFSEPNQALTKLLFTQKTDRQLLVLQDPTAHTAAATSSCLFSVHSSLQGSIGLQRTGSLSRKRGERASQRGCPRPLSLHCSGSLEASALPPEAGDSGRHPLYQLLNCGPRNRALYPDIARMEQLLQQAVAERERLLQAREGTRRSKEGSSGPPVPAIMAPPAPPSSPAGPRVLDLRQHLERWGHNPENCPHLRVSGGCCRGPLVKMGGRIKTWRKRWFCFDRQARRLAYYADKEETKLKGVIYFQAIEEVYYDHLRCAFKSPNPRLTFCVKTYERLFYMVAPSPEAVRIWMDVIVTAADENHAP", "length": 640 }, "evidence": [ { "id": "A0A0G2KB72", "url": "https://omabrowser.org/oma/group/A0A0G2KB72/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "Q6NSJ2-1", "protein_name": "Pleckstrin homology-like domain family B member 3", "gene_name": "PHLDB3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGTRSSPEEGTPPPLVPECDVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRLLELNCLQGTPGGDFSEPNPALTKLLFTQKTDRQLLVLQDAVAHSAATPTSSCLFSVHSSLQGSIGLQRTGSLPRKRGERGSQRGSPRPLSFHCTESLEASALPPAVGDSGRYPLYQLLNCGRGNSCGAIHPDIAHMERLLQQAMAERERLLKAREGTRRGTEGSSGPAVPAITAPPTPPHPPGPRILDLRQHLEGWGHNPENCPHVQVSGCCCRGPLVKMGGRIKTWRKRWFCFDRQARRLAYYADKEETKLKGVIYFQAIEEVYYDHLRCAFKSPNPRLTFCVKTYERLFYMVAPSPEAMRIWMDVIVTAADENHAP", "length": 640 }, "evidence": [ { "id": "A0A0G2KB72", "url": "https://omabrowser.org/oma/group/A0A0G2KB72/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB72", "url": "https://www.uniprot.org/uniprot/A0A0G2KB72" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A0G2KB72-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 636, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A0G2KB72-F1.pdb" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 89 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "prediction_tool", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "prediction_tool", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }